Phenotypes associated with this allele

• Allele Symbol: Gckr^tm1Jfg
• Allele Name: targeted mutation 1, Joseph F Grippo
• Allele ID: MGI:2386670
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gckr^tm1Jfg/Gckr^tm1Jfg	involves: 129S/SvEv * C57BL/6J	MGI:2446100

Genotype
MGI:2446100

hm1

• Allelic Composition: Gckr^tm1Jfg/Gckr^tm1Jfg
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating insulin level ( J:61183 )

• although plasma glucose and insulin levels are statistically normal, a trend toward decreased insulin is observed in older animals fed ad libitum

abnormal enzyme/coenzyme level ( J:61183 )

• liver protein levels of glucokinase decreased 75% while transcription levels are normal

impaired glucose tolerance ( J:61183 )

• moderately

decreased glucokinase activity ( J:61183 )

• decreased glucokinase activity in the liver by 41%

• glucokinase activity not affected by sorbitol-6-phosphate inhibitor

• glucokinase activity drops significantly after addition of fructose-1-phosphate