All Phenotypes Inhba<tm2Zuk> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Inhba^tm2Zuk/Inhba^tm2Zuk	involves: 129S7/SvEvBrd	MGI:3758908
ht2	Inhba^tm1Zuk/Inhba^tm2Zuk	involves: 129S7/SvEvBrd	MGI:3758909

Allelic Composition	Inhba^tm2Zuk/Inhba^tm2Zuk
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inhba^tm2Zuk mutation (1 available); any Inhba mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:63882 )

• 50% of mice die by week 26

reproductive system

decreased testis weight ( J:63882 )

• testis weight is decreased to 50% of Inhba^tm2Zuk heterozygotes testis weight

large penis ( J:63882 )

enlarged clitoris ( J:63882 )

• female mice have prominent os clitori

enlarged external male genitalia ( J:63882 )

• some males have enlarged external genitalia and retracted foreskin

delayed male fertility ( J:63882 )

• the onset of male fertility is delayed (31.7+/-2.5 days after mating pairs were established compared to 22+/-1.2 days for Inhba^tm2Zuk heterozygotes)

female infertility ( J:63882 )

• only 1 of 6 females produced litters

homeostasis/metabolism

abnormal circulating hormone level ( J:63882 )

• dehydroepiandrosterone sulphate levels but not testosterone levels are increased in males and females

hematopoietic system

anemia ( J:63882 )

• mild

decreased hematocrit ( J:63882 )

• 40+/-2.3% compared to 44+/-0.7% in wild-type mice

vision/eye

enophthalmos ( J:63882 )

growth/size/body

decreased body size ( J:63882 )

endocrine/exocrine glands

decreased testis weight ( J:63882 )

• testis weight is decreased to 50% of Inhba^tm2Zuk heterozygotes testis weight

renal/urinary system

large penis ( J:63882 )

craniofacial

craniofacial phenotype ( J:63882 )

N	• mice have normal palate and tooth development

integument

integument phenotype ( J:63882 )

N	• mice have normal whisker development

retarded hair growth ( J:63882 )

short hair ( J:63882 )

sparse hair ( J:63882 )

• female mice have sparse perigenital hair

rough coat ( J:63882 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:63882 )

• mice become cachectic and die between 3 and 4 weeks

reproductive system

decreased mature ovarian follicle number ( J:63882 )

• in adult mice the number of preovulatory follicles is reduced compared to in wild-type mice

decreased secondary ovarian follicle number ( J:63882 )

• ovaries contain fewer preantral follicles than in Inhba^tm2Zuk heterozygotes

small ovary ( J:63882 )

abnormal seminiferous tubule morphology ( J:63882 )

• differentiation of the seminiferous tubules is delayed

decreased testis weight ( J:63882 )

• testis weight is decreased more substantially than in Inhba^tm2Zuk homozygotes

large penis ( J:63882 )

enlarged clitoris ( J:63882 )

• female mice have prominent os clitori

enlarged external male genitalia ( J:63882 )

• some males have enlarged external genitalia and retracted foreskin

homeostasis/metabolism

hypoglycemia ( J:63882 )

• blood glucose level is reduced to 78.4+/-8 mg/dl compared to 129+/-7.8 mg/dl in wild-type mice

decreased circulating estradiol level ( J:63882 )

increased circulating follicle stimulating hormone level ( J:63882 )

• serum follicle stimulating hormone levels are 50% higher than those of wild-type mice

decreased circulating progesterone level ( J:63882 )

• serum progesterone levels are less than 50% of those in wild-type mice

hematopoietic system

anemia ( J:63882 )

• mild to moderate

decreased hematocrit ( J:63882 )

• 36+/-1.0% compared to 44+/-0.7% in wild-type mice

vision/eye

enophthalmos ( J:63882 )

growth/size/body

cachexia ( J:63882 )

endocrine/exocrine glands

decreased mature ovarian follicle number ( J:63882 )

• in adult mice the number of preovulatory follicles is reduced compared to in wild-type mice

decreased secondary ovarian follicle number ( J:63882 )

• ovaries contain fewer preantral follicles than in Inhba^tm2Zuk heterozygotes

small ovary ( J:63882 )

abnormal seminiferous tubule morphology ( J:63882 )

• differentiation of the seminiferous tubules is delayed

decreased testis weight ( J:63882 )

• testis weight is decreased more substantially than in Inhba^tm2Zuk homozygotes

renal/urinary system

large penis ( J:63882 )

craniofacial

craniofacial phenotype ( J:63882 )

N	• mice have normal palate and tooth development

integument

integument phenotype ( J:63882 )

N	• mice have normal whisker development

retarded hair growth ( J:63882 )

sparse hair ( J:63882 )

• female mice have sparse perigenital hair

rough coat ( J:63882 )

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