All Phenotypes Il1rl1<tm1Anjm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il1rl1^tm1Anjm
targeted mutation 1, Andrew NJ McKenzie
MGI:2386675

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il1rl1^tm1Anjm/Il1rl1^tm1Anjm	C.129P2-Il1rl1^tm1Anjm	MGI:5428201
hm2	Il1rl1^tm1Anjm/Il1rl1^tm1Anjm	involves: 129P2/OlaHsd	MGI:4457619
hm3	Il1rl1^tm1Anjm/Il1rl1^tm1Anjm	involves: 129P2/OlaHsd * C57BL/6	MGI:3584527
cx4	Il17rb^tm1Anjm/Il17rb^tm1Anjm Il1rl1^tm1Anjm/Il1rl1^tm1Anjm	involves: 129P2/OlaHsd * BALB/c	MGI:4457620
cx5	Il13^tm3.1Anjm/Il13⁺ Il17rb^tm1Anjm/Il17rb^tm1Anjm Il1rl1^tm1Anjm/Il1rl1^tm1Anjm	involves: 129P2/OlaHsd * BALB/c	MGI:4457697
cx6	Il13^tm3.1Anjm/Il13⁺ Il1rl1^tm1Anjm/Il1rl1^tm1Anjm	involves: 129P2/OlaHsd * BALB/c	MGI:4457698

Allelic Composition	Il1rl1^tm1Anjm/Il1rl1^tm1Anjm
Genetic Background	C.129P2-Il1rl1^tm1Anjm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1rl1^tm1Anjm mutation (1 available); any Il1rl1 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased susceptibility to induced pancreatitis ( J:184801 )

• 72 hours after a choline-deficient-ethionine-supplemented (CDE) diet, mutants exhibit more severe necrosis, inflammation, and edema in the pancreas and higher levels of hydrolases and serum IL-6 than wild-type mice, indicating increased susceptibility to development of acute pancreatitis

• mutants present more severe pancreatitis disease after 10 hourly cerulean injections compared to wild-type mice, with higher hydrolase levels, higher edema, inflammation and necrosis

• mutants induced to develop acute pancreatitis, exhibit a greater increase in tryptase levels than wild-type mice, indicating an increase in mast cell activation

immune system

increased susceptibility to induced pancreatitis ( J:184801 )

• mutants present more severe pancreatitis disease after 10 hourly cerulean injections compared to wild-type mice, with higher hydrolase levels, higher edema, inflammation and necrosis

• mutants induced to develop acute pancreatitis, exhibit a greater increase in tryptase levels than wild-type mice, indicating an increase in mast cell activation

Allelic Composition	Il1rl1^tm1Anjm/Il1rl1^tm1Anjm
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1rl1^tm1Anjm mutation (1 available); any Il1rl1 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased eosinophil cell number ( J:159464 )

• decreased Nuocytes after infection with the helminth parasite N. brasiliensis

decreased IgE level ( J:159464 )

hematopoietic system

decreased eosinophil cell number ( J:159464 )

• decreased Nuocytes after infection with the helminth parasite N. brasiliensis

decreased IgE level ( J:159464 )

Allelic Composition	Il1rl1^tm1Anjm/Il1rl1^tm1Anjm
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1rl1^tm1Anjm mutation (1 available); any Il1rl1 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal eosinophil physiology ( J:61108 )

• reduced lung tissue eosinophilia after challenge

abnormal T-helper 2 physiology ( J:61108 )

• impaired ability to generate a Th2 type inflammatory response

abnormal interleukin secretion ( J:61108 )

• impaired ability to generate Il4 and Il5

decreased interleukin-4 secretion ( J:61108 )

decreased interleukin-5 secretion ( J:61108 )

granulomatous inflammation ( J:61108 )

• failure to form pulmonary granulomas after challenge with eggs of Schistosoma mansoni

hematopoietic system

abnormal eosinophil physiology ( J:61108 )

• reduced lung tissue eosinophilia after challenge

abnormal T-helper 2 physiology ( J:61108 )

• impaired ability to generate a Th2 type inflammatory response

Allelic Composition	Il17rb^tm1Anjm/Il17rb^tm1Anjm Il1rl1^tm1Anjm/Il1rl1^tm1Anjm
Genetic Background	involves: 129P2/OlaHsd * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17rb^tm1Anjm mutation (0 available); any Il17rb mutation (42 available)
Il1rl1^tm1Anjm mutation (1 available); any Il1rl1 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased eosinophil cell number ( J:159464 )

• decreased Nuocytes after infection with the helminth parasite N. brasiliensis

decreased IgE level ( J:159464 )

increased susceptibility to parasitic infection ( J:159464 )

• in response to infection with the helminth parasite N. brasiliensis, worm expulsion is severely impaired and mice possess significant worm burden at 20 days post infection

hematopoietic system

decreased eosinophil cell number ( J:159464 )

• decreased Nuocytes after infection with the helminth parasite N. brasiliensis

decreased IgE level ( J:159464 )

Allelic Composition	Il13^tm3.1Anjm/Il13⁺ Il17rb^tm1Anjm/Il17rb^tm1Anjm Il1rl1^tm1Anjm/Il1rl1^tm1Anjm
Genetic Background	involves: 129P2/OlaHsd * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13^tm3.1Anjm mutation (0 available); any Il13 mutation (30 available)
Il17rb^tm1Anjm mutation (0 available); any Il17rb mutation (42 available)
Il1rl1^tm1Anjm mutation (1 available); any Il1rl1 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased eosinophil cell number ( J:159464 )

• decreased Nuocytes after infection with the helminth parasite N. brasiliensis

immune system

decreased eosinophil cell number ( J:159464 )

• decreased Nuocytes after infection with the helminth parasite N. brasiliensis

Allelic Composition	Il13^tm3.1Anjm/Il13⁺ Il1rl1^tm1Anjm/Il1rl1^tm1Anjm
Genetic Background	involves: 129P2/OlaHsd * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13^tm3.1Anjm mutation (0 available); any Il13 mutation (30 available)
Il1rl1^tm1Anjm mutation (1 available); any Il1rl1 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased eosinophil cell number ( J:159464 )

• decreased Nuocytes after infection with the helminth parasite N. brasiliensis

immune system

decreased eosinophil cell number ( J:159464 )

• decreased Nuocytes after infection with the helminth parasite N. brasiliensis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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