Phenotypes associated with this allele

• Allele Symbol: Satb1^tm1Kos
• Allele Name: targeted mutation 1, Terumi Kohwi-Shigematsu
• Allele ID: MGI:2386676
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Satb1^tm1Kos/Satb1^tm1Kos	involves: 129P2/OlaHsd * C57BL/6	MGI:3521740

Genotype
MGI:3521740

hm1

• Allelic Composition: Satb1^tm1Kos/Satb1^tm1Kos
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:61085 )

• all die by 4 weeks of age

• most mice die between P21 and P26

behavior/neurological

limb grasping ( J:61085 )

• clasping reflex

growth/size/body

decreased body size ( J:61085 )

• by 3 days of age, animals were smaller and thinner than controls; progressive increase in difference with age was noted

postnatal growth retardation ( J:61085 )

hematopoietic system

abnormal T cell proliferation ( J:61085 )

• the few mature T cells underwent apoptosis and failed to proliferate in response to PMA and ionomycin

small thymus ( J:61085 )

• composed mostly of cortex, with degenerating cells and a sparse medulla

decreased thymocyte number ( J:61085 )

• progressive reduction with age

abnormal T cell differentiation ( J:61085 )

• reduced numbers of triple negative immature thymocytes

arrested T cell differentiation ( J:61085 )

• mutant thymocytes were mostly blocked at the double-positive stage

small spleen ( J:61085 )

• contained shrunken white pulp

immune system

abnormal T cell proliferation ( J:61085 )

• the few mature T cells underwent apoptosis and failed to proliferate in response to PMA and ionomycin

small thymus ( J:61085 )

• composed mostly of cortex, with degenerating cells and a sparse medulla

decreased thymocyte number ( J:61085 )

• progressive reduction with age

abnormal T cell differentiation ( J:61085 )

• reduced numbers of triple negative immature thymocytes

arrested T cell differentiation ( J:61085 )

• mutant thymocytes were mostly blocked at the double-positive stage

small spleen ( J:61085 )

• contained shrunken white pulp

small lymph nodes ( J:61085 )

• reduced numbers of lymphocytes in lymph node

vision/eye

delayed eyelid opening ( J:61085 )

• incomplete eye opening

endocrine/exocrine glands

small thymus ( J:61085 )

• composed mostly of cortex, with degenerating cells and a sparse medulla

decreased thymocyte number ( J:61085 )

• progressive reduction with age

cellular

abnormal T cell proliferation ( J:61085 )

• the few mature T cells underwent apoptosis and failed to proliferate in response to PMA and ionomycin