Phenotypes associated with this allele

• Allele Symbol: Ppard^tm1.1Rev
• Allele Name: targeted mutation 1.1, Ronald M Evans
• Allele ID: MGI:2386684
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppard^tm1.1Rev/Ppard^tm1.1Rev	Not Specified	MGI:3715725
cx2	Apc^Min/Apc^Min Ppard^tm1.1Rev/Ppard^tm1.1Rev	involves: C57BL/6J	MGI:3715726

Genotype
MGI:3715725

hm1

• Allelic Composition: Ppard^tm1.1Rev/Ppard^tm1.1Rev
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Pathologies of Ppard^tm1.1Rev/Ppard^tm1.1Rev mouse placentas

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:73557 )

• embryonic lethality and sub-Mendelian ratios are observed from E10.5 onward; only 4.5-12% of surviving pups at birth are homozygous from heterozygous intercrosses or homo/heterozygous intercrosses

embryo

embryonic growth retardation ( J:73557 )

• homozygotes surviving beyond E10.5 are growth restricted and smaller than littermates

decreased placental labyrinth size ( J:73557 )

• labyrinth is smaller, but has fully differentiatied vascular structure

abnormal placenta development ( J:73557 )

• embryos have abnormal connections between the placenta and maternal deciduas

growth/size/body

embryonic growth retardation ( J:73557 )

• homozygotes surviving beyond E10.5 are growth restricted and smaller than littermates

adipose tissue

abnormal adipose tissue morphology ( J:73557 )

• adipose stores associated with internal organs like the heart and kidney are underdeveloped in 4 month-old mice

decreased subcutaneous adipose tissue amount ( J:73557 )

• fat layer is 2-fold thinner

abnormal fat cell morphology ( J:73557 )

• mice show combined decrease in cell number and size in subcutaneous fat layer

decreased mesenteric fat pad weight ( J:73557 )

• mesenteric fat is underdeveloped at 4 months of age

decreased abdominal fat pad weight ( J:73557 )

• mice show 2.5-fold reduction in abdominal fat mass compared to controls postnatally

decreased interscapular fat pad weight ( J:73557 )

• relative mass of interscapular brown fat stores drop by ~70% postnatally

integument

decreased subcutaneous adipose tissue amount ( J:73557 )

• fat layer is 2-fold thinner

Genotype
MGI:3715726

cx2

• Allelic Composition: Apc^Min/Apc^Min; Ppard^tm1.1Rev/Ppard^tm1.1Rev
• Genetic Background: involves: C57BL/6J

digestive/alimentary system

increased intestinal adenoma incidence ( J:73557 )

• polyps are low grade noninvasive tubular adenomas

intestine polyps ( J:73557 )

• mice harbor conspicuous intestinal polyps; average number is similar to wild-type and heterozygous mice

• there is a decrease in large diameter polyps relative to controls, while small polyp number is similar between all groups

colon polyps ( J:73557 )

• mice harbor conspicuous colonic polyps

neoplasm

increased intestinal adenoma incidence ( J:73557 )

• polyps are low grade noninvasive tubular adenomas