Phenotypes associated with this allele

• Allele Symbol: Tg(Fabp4-cre)1Rev
• Allele Name: transgene insertion 1, Ronald M Evans
• Allele ID: MGI:2386686
• Summary: 34 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Abcc6^tm1c(EUCOMM)Wtsi/Abcc6^tm1c(EUCOMM)Wtsi Tg(Fabp4-cre)1Rev/?	B6.Cg-Abcc6^tm1c(EUCOMM)Wtsi Tg(Fabp4-cre)1Rev	MGI:6241516
cn2	Apoe^tm1.1Mae/Apoe^tm1.1Mae Tg(Fabp4-cre)1Rev/0	B6.Cg-Apoe^tm1.1Mae Tg(Fabp4-cre)1Rev	MGI:5704295
cn3	Ppargc1a^tm1.1Javi/Ppargc1a^tm1.1Javi Tg(Fabp4-cre)1Rev/0	B6.Cg-Ppargc1a^tm1.1Javi Tg(Fabp4-cre)1Rev	MGI:5319542
cn4	Rictor^tm1.1Mnh/Rictor^tm1.1Mnh Tg(Fabp4-cre)1Rev/0	B6.Cg-Rictor^tm1.1Mnh Tg(Fabp4-cre)1Rev	MGI:3850095
cn5	Bscl2^tm1.1Gliu/Bscl2^tm1.1Gliu Tg(Fabp4-cre)1Rev/0	involves: 129 * 129S4/SvJaeSor	MGI:5629954
cn6	Klb^tm1.1Sakl/Klb^tm1.1Sakl Tg(Fabp4-cre)1Rev/0	involves: 129 * C57BL/6 * SJL	MGI:5446167
cn7	Eif3m^tm1Nju/Eif3m^tm1Nju Tg(Fabp4-cre)1Rev/0	involves: 129 * FVB/N	MGI:5553078
cn8	Acsl1^tm1Rcol/Acsl1^tm1Rcol Tg(Fabp4-cre)1Rev/0	involves: 129P2/OlaHsd * C57BL/6	MGI:6103877
cn9	Cxcr4^tm2Yzo/Cxcr4^tm2Yzo Tg(Fabp4-cre)1Rev/0	involves: 129P2/OlaHsd * C57BL/6	MGI:6116483
cn10	Pnpla2^tm1.1Hsul/Pnpla2^tm1.1Hsul Tg(Fabp4-cre)1Rev/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL	MGI:5296241
cn11	Ppargc1b^tm1.1Javi/Ppargc1b^tm1.1Javi Tg(Fabp4-cre)1Rev/?	involves: 129P2/OlaHsd * C57BL/6J	MGI:5696655
cn12	Ar^tm1Verh/Y Tg(Fabp4-cre)1Rev/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5502687
cn13	Rptor^tm1Rueg/Rptor^tm1Rueg Tg(Fabp4-cre)1Rev/0	involves: 129S1/SvImJ * C57BL/6J	MGI:3829752
cn14	Pparg^tm2Rev/Pparg^tm2Rev Tg(Fabp4-cre)1Rev/0	involves: 129S4/SvJae * C57BL/6	MGI:3033749
cn15	Fitm2^tm1.1Dls/Fitm2^tm1.1Dls Lep^ob/Lep^ob Tg(Fabp4-cre)1Rev/?	involves: 129S6/SvEvTac * C57BL/6J	MGI:5707240
cn16	Fitm2^tm1.1Dls/Fitm2^tm1.1Dls Tg(Fabp4-cre)1Rev/?	involves: 129S6/SvEvTac * C57BL/6J	MGI:5707239
cn17	Lrp1^tm2Her/Lrp1^tm2Her Tg(Fabp4-cre)1Rev/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:4943736
cn18	Grb10^tm1.1Fliu/Grb10^tm1.1Fliu Tg(Fabp4-cre)1Rev/0	involves: 129S/SvEv	MGI:6107174
cn19	Stat3^tm1Jbha/Stat3^tm1Jbha Tg(Fabp4-cre)1Rev/0	involves: 129S/SvEv * C57BL/6	MGI:3804264
cn20	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Fabp4-cre)1Rev/0	involves: C57BL/6	MGI:5515332
cn21	Tbl1xr1^tm1.1Arte/Tbl1xr1^tm1.1Arte Tg(Fabp4-cre)1Rev/0	involves: C57BL/6	MGI:5512646
cn22	Lep^ob/Lep^ob Nfe2l2^tm1.1Jgpi/Nfe2l2^tm1.1Jgpi Tg(Fabp4-cre)1Rev/0	involves: C57BL/6	MGI:5567001
cn23	Sufu^tm1Hui/Sufu^tm1Hui Tg(Fabp4-cre)1Rev/0	involves: C57BL/6	MGI:4840474
cn24	Hdac3^tm1.1Laz/Hdac3^tm1.1Laz Tg(Fabp4-cre)1Rev/0	involves: C57BL/6	MGI:5515397
cn25	Rala^tm1.2Cjm/Rala^tm1.2Cjm Tg(Fabp4-cre)1Rev/0	involves: C57BL/6 * C57BL/6J	MGI:5505296
cn26	Rala^tm1.2Cjm/Rala^tm1.2Cjm Ralb^tm1.2Cjm/Ralb^tm1.2Cjm Tg(Fabp4-cre)1Rev/0	involves: C57BL/6 * C57BL/6J	MGI:5505298
cn27	Ralb^tm1.2Cjm/Ralb^tm1.2Cjm Tg(Fabp4-cre)1Rev/0	involves: C57BL/6 * C57BL/6J	MGI:5505297
cn28	Agt^tm1.1Itl/Agt^tm1.1Itl Tg(Fabp4-cre)1Rev/0	involves: C57BL/6 * C57BL/6J * C57BL/6NTac * SJL	MGI:5305953
cn29	Agtr1a^tm1.1Uky/Agtr1a^tm1.1Uky Tg(Fabp4-cre)1Rev/0	involves: C57BL/6 * C57BL/6N * SJL	MGI:5468256
cn30	Hmox1^tm1.1Hes/Hmox1^tm1.1Hes Tg(Fabp4-cre)1Rev/0	involves: C57BL/6J * C57BL/6N	MGI:5660651
cn31	Gpcpd1^tm1c(EUCOMM)Hmgu/Gpcpd1^tm1c(EUCOMM)Hmgu Tg(Fabp4-cre)1Rev/0	involves: C57BL/6J * C57BL/6N	MGI:7610685
cn32	Ghr^tm1c(KOMP)Wtsi/Ghr^tm1c(KOMP)Wtsi Tg(Fabp4-cre)1Rev/0	involves: C57BL/6N	MGI:5550143
cn33	Sqstm1^tm2.1Jmos/Sqstm1^tm2.1Jmos Tg(Fabp4-cre)1Rev/0	Not Specified	MGI:5487465
cn34	Ppard^tm1Rev/Ppard^tm1Rev Tg(Fabp4-cre)1Rev/0	Not Specified	MGI:3715727

Genotype
MGI:6241516

cn1

• Allelic Composition: Abcc6^{tm1c(EUCOMM)Wtsi}/Abcc6^{tm1c(EUCOMM)Wtsi}; Tg(Fabp4-cre)1Rev/?
• Genetic Background: B6.Cg-Abcc6^{tm1c(EUCOMM)Wtsi} Tg(Fabp4-cre)1Rev

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

integument phenotype ( J:252837 )

N • no calcification occurs in the fibrous capsule surrounding the muzzle vibrissae

Genotype
MGI:5704295

cn2

• Allelic Composition: Apoe^tm1.1Mae/Apoe^tm1.1Mae; Tg(Fabp4-cre)1Rev/0
• Genetic Background: B6.Cg-Apoe^tm1.1Mae Tg(Fabp4-cre)1Rev

cardiovascular system

decreased cardiac muscle triglyceride level ( J:219838 )

♂

adipose tissue

decreased white fat cell lipid droplet size ( J:219838 )

♂

decreased white fat cell size ( J:219838 )

♂ • reduced adipocyte volume

decreased epididymal fat pad weight ( J:219838 )

♂ • ratio of epididymal fat pad weight to body weight is reduced

♂ • adipocyte number is not decreased, however, adipocyte size and lipid content is reduced

muscle

decreased cardiac muscle triglyceride level ( J:219838 )

♂

decreased skeletal muscle triglyceride level ( J:219838 )

♂

hematopoietic system

decreased macrophage cell number ( J:219838 )

♂ • numbers of inflammatory adipose tissue macrophages (M1) are decreased, although total number is similar to control

increased macrophage cell number ( J:219838 )

♂ • numbers of non-inflammatory adipose tissue macrophage (M2) are increased, although total number is similar to controls

homeostasis/metabolism

decreased circulating glucose level ( J:219838 )

♂

decreased circulating insulin level ( J:219838 )

♂

improved glucose tolerance ( J:219838 )

♂

increased insulin sensitivity ( J:219838 )

♂ • reduced HOMA-IR

decreased cholesterol level ( J:219838 )

♂ • decreased cholesterol level in white adipose tissue and heart

decreased circulating cholesterol level ( J:219838 )

♂ • reduced plasma total cholesterol

decreased liver cholesterol level ( J:219838 )

♂

increased cholesterol level ( J:219838 )

♂ • increased cholesterol level in skeletal muscle

decreased triglyceride level ( J:219838 )

♂ • decreased triglyceride level in white adipose tissue

decreased cardiac muscle triglyceride level ( J:219838 )

♂

decreased circulating triglyceride level ( J:219838 )

♂ • reduced plasma triglyceride at 12-13 weeks, but not 8 weeks

decreased liver triglyceride level ( J:219838 )

♂

decreased skeletal muscle triglyceride level ( J:219838 )

♂

immune system

decreased macrophage cell number ( J:219838 )

♂ • numbers of inflammatory adipose tissue macrophages (M1) are decreased, although total number is similar to control

increased macrophage cell number ( J:219838 )

♂ • numbers of non-inflammatory adipose tissue macrophage (M2) are increased, although total number is similar to controls

liver/biliary system

decreased liver cholesterol level ( J:219838 )

♂

decreased liver triglyceride level ( J:219838 )

♂

Genotype
MGI:5319542

cn3

• Allelic Composition: Ppargc1a^tm1.1Javi/Ppargc1a^tm1.1Javi; Tg(Fabp4-cre)1Rev/0
• Genetic Background: B6.Cg-Ppargc1a^tm1.1Javi Tg(Fabp4-cre)1Rev

adipose tissue

adipose tissue phenotype ( J:180984 )

N • response to rosiglitazone is similar to controls

decreased total body fat amount ( J:180984 )

• on a high fat diet in a thermoneutral environment

abnormal brown fat cell morphology ( J:180984 )

• practically indistinguishable from white adipocytes due to large accumulation of triglycerides in mice on a high fat diet in a thermoneutral environment

decreased brown fat cell size ( J:180984 )

• on a high fat diet in a thermoneutral environment

decreased white fat cell size ( J:180984 )

• on a high fat diet in a thermoneutral environment

growth/size/body

decreased body weight ( J:180984 )

• on a high fat diet in a thermoneutral environment

• on a regular chow diet in a thermoneutral environment weigh slightly but not significantly less than littermate controls

liver/biliary system

decreased liver weight ( J:180984 )

• slight reduction when on a high fat diet in a thermoneutral environment

Genotype
MGI:3850095

cn4

• Allelic Composition: Rictor^tm1.1Mnh/Rictor^tm1.1Mnh; Tg(Fabp4-cre)1Rev/0
• Genetic Background: B6.Cg-Rictor^tm1.1Mnh Tg(Fabp4-cre)1Rev

growth/size/body

increased heart weight ( J:150064 )

• weight of organ in mice fed a chow diet is increased by 40% compared to controls

• weight of organ in mice fed a high fat diet is increased by 40% compared to controls

increased pancreas weight ( J:150064 )

• weight of organ in mice fed a chow diet is increased by 41% compared to controls

• weight of organ in mice fed a high fat diet is increased by 129% compared to controls

increased lean body mass ( J:150064 )

• mice on a high fat diet significantly increase their lean body mass compared to diet-matched controls

increased body length ( J:150064 )

• body length of mice on a high fat diet is significantly longer than controls

increased susceptibility to weight gain ( J:150064 )

• starting at 8 weeks of age, mice gain weight on a chow diet at a slightly higher rate than controls so that they are 4% heavier at 18 weeks of age

increased kidney weight ( J:150064 )

• weight of organ in mice fed a chow diet is increased by 28% compared to controls

• weight of organ in mice fed a high fat diet is increased by 47% compared to controls

increased liver weight ( J:150064 )

• weight of liver in mice fed a high fat diet is increased by 75% compared to controls

increased spleen weight ( J:150064 )

• weight of organ in mice fed a chow diet is increased by 38% compared to controls

• weight of organ in mice fed a high fat diet is increased by 62% compared to controls

homeostasis/metabolism

increased circulating insulin level ( J:150064 )

• insulin levels are significantly increased in fasted or fed mice, on either a chow or high-fat diet

increased circulating insulin-like growth factor I level ( J:150064 )

• IGF-1 serum levels are significantly increased on either a chow (21%) or a high fat diet (58%)

increased circulating cholesterol level ( J:150064 )

• cholesterol levels are increased by almost 70% in mice fed a chow diet

• cholesterol levels are similar to controls when fed a high fat diet

improved glucose tolerance ( J:150064 )

• mice are glucose tolerant on a chow diet despite being hyperinsulinemic

• mice have improved glucose tolerance on a high fat diet relative to controls

insulin resistance ( J:150064 )

• mice are slightly insulin resistance

decreased adiponectin level ( J:150064 )

• adiponectin levels are decreased about 30% on either a chow or high fat diet

adipose tissue

increased epididymal fat pad weight ( J:150064 )

• epididymal fat pad is increased by 30% on a high fat diet compared to diet-matched controls

endocrine/exocrine glands

enlarged pancreatic islets ( J:150064 )

• pancreatic islet cells are at least 2-fold larger than controls with beta cells weighing twice as much as controls

increased pancreas weight ( J:150064 )

• weight of organ in mice fed a chow diet is increased by 41% compared to controls

• weight of organ in mice fed a high fat diet is increased by 129% compared to controls

cardiovascular system

increased heart weight ( J:150064 )

• weight of organ in mice fed a chow diet is increased by 40% compared to controls

• weight of organ in mice fed a high fat diet is increased by 40% compared to controls

hematopoietic system

increased spleen weight ( J:150064 )

• weight of organ in mice fed a chow diet is increased by 38% compared to controls

• weight of organ in mice fed a high fat diet is increased by 62% compared to controls

immune system

increased spleen weight ( J:150064 )

• weight of organ in mice fed a chow diet is increased by 38% compared to controls

• weight of organ in mice fed a high fat diet is increased by 62% compared to controls

liver/biliary system

increased liver weight ( J:150064 )

• weight of liver in mice fed a high fat diet is increased by 75% compared to controls

macrovesicular hepatic steatosis ( J:150064 )

• mice fed a high fat diet have more advanced steatosis than diet-matched controls

• the liver is larger and contains enlarged lipid droplets

renal/urinary system

increased kidney weight ( J:150064 )

• weight of organ in mice fed a chow diet is increased by 28% compared to controls

• weight of organ in mice fed a high fat diet is increased by 47% compared to controls

skeleton

increased bone mineral content ( J:150064 )

• there is a 15% increase in bone mineral content compared to controls

• bone density is normal indicating the skeleton is larger than controls

Genotype
MGI:5629954

cn5

• Allelic Composition: Bscl2^tm1.1Gliu/Bscl2^tm1.1Gliu; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129 * 129S4/SvJaeSor

adipose tissue

lipodystrophy ( J:211072 )

♂ • males develop progressive lipodystrophy

homeostasis/metabolism

increased circulating insulin level ( J:211072 )

♂ • increase in fed plasma insulin levels

increased circulating cholesterol level ( J:211072 )

♂

reproductive system

reproductive system phenotype ( J:211072 )

♂N • males exhibit normal mating behavior and sire offspring at normal frequencies, indicating normal fertility, show normal serum FSH, LH, testosterone and estradiol levels, and exhibit normal sperm

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
male infertility		DOID:12336		J:211072

Genotype
MGI:5446167

cn6

• Allelic Composition: Klb^tm1.1Sakl/Klb^tm1.1Sakl; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129 * C57BL/6 * SJL

homeostasis/metabolism

abnormal glucose homeostasis ( J:189018 )

• during a hyperinsulinemic-euglycemic clamp, mice fed a high fat diet and treated with FGF21 fail to exhibit an increase in glucose infusion rate and whole-body and brown adipose tissue glucose uptake or reduction in endogenous glucose production observed in FGF-treated control mice

increased insulin sensitivity ( J:189018 )

• mice fed standard chow or a high fat diet and treated with FGF21 exhibit improved insulin sensitivity compared with control mice

adipose tissue

abnormal adipose tissue physiology ( J:189018 )

• during a hyperinsulinemic-euglycemic clamp, mice fed a high fat diet and treated with FGF21 fail to exhibit an increase in brown adipose tissue glucose uptake observed in FGF-treated control mice

Genotype
MGI:5553078

cn7

• Allelic Composition: Eif3m^tm1Nju/Eif3m^tm1Nju; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129 * FVB/N

Severe growth retardation in Eif3m^tm1Nju/Eif3m^tm1Nju Tg(Fabp4-cre)1Rev/0 embryos at E9.5

mortality/aging

embryonic lethality, complete penetrance ( J:204915 )

embryo

embryonic growth retardation ( J:204915 )

• severe at E9.5, but not as severe as in Eif3m^tm1Nju/Eif3m^tm1Nju Tg(Fabp4-cre)1Rev mice

growth/size/body

embryonic growth retardation ( J:204915 )

• severe at E9.5, but not as severe as in Eif3m^tm1Nju/Eif3m^tm1Nju Tg(Fabp4-cre)1Rev mice

Genotype
MGI:6103877

cn8

• Allelic Composition: Acsl1^tm1Rcol/Acsl1^tm1Rcol; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

homeostasis/metabolism

decreased fatty acid oxidation ( J:162996 )

• in white adipose tissue

impaired adaptive thermogenesis ( J:162996 )

• in cold exposed mice due to decreased fatty acid oxidation

hypoglycemia ( J:162996 )

• during cold exposure

• after adrenergic stimuli with isoproterenol or CL-316243

• however, glucose levels are normal after fasting

decreased circulating glycerol level ( J:162996 )

• in response to CL-316243 due to reduced glycerol release by brown adipocytes

hyperlipidemia ( J:162996 )

• after adrenergic stimuli

increased fatty acids level ( J:162996 )

• in white adipose tissue when fed a low-fat diet with different fatty acid species

increased circulating free fatty acids level ( J:162996 )

• after cold exposure or CL-316243 treatment

• however, fasting does not abnormally increase fatty acid levels

increased triglyceride level ( J:162996 )

• with increased diacylglycerol level in white adipose tissue when fed a low-fat diet

increased circulating triglyceride level ( J:162996 )

• after cold exposure

decreased lipoprotein lipase activity ( J:162996 )

• when fed a low-fat diet

adipose tissue

increased body fat mass ( J:162996 )

• when fed a 10% fat diet

• however, mice fed a high-fat diet exhibit normal weight gain and adipocity

increased epididymal fat pad weight ( J:162996 )

• when fed a low-fat diet

• however, mice fed a high-fat diet exhibit lipid levels

increased gonadal fat pad weight ( J:162996 )

• when fed a 10% fat diet or chow

• however, adipocyte size is normal

growth/size/body

increased body fat mass ( J:162996 )

• when fed a 10% fat diet

• however, mice fed a high-fat diet exhibit normal weight gain and adipocity

cellular

decreased fatty acid oxidation ( J:162996 )

• in white adipose tissue

Genotype
MGI:6116483

cn9

• Allelic Composition: Cxcr4^tm2Yzo/Cxcr4^tm2Yzo; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

adipose tissue

increased subcutaneous adipose tissue amount ( J:217569 )

• 1.8-fold in mice fed a high-fat diet

increased total body fat amount ( J:217569 )

• 2-fold increase in mice fed a high-fat diet

increased brown adipose tissue mass ( J:217569 )

• 2-fold in mice fed a high-fat diet

increased brown fat cell size ( J:217569 )

• in mice fed a high-fat diet

increased white fat cell size ( J:217569 )

• in mice fed a high-fat diet

increased gonadal fat pad weight ( J:217569 )

• 1.6-fold in visceral (mesenteric, retroperitoneal, and gonadal) white adipose tissue mice fed a high-fat diet

increased mesenteric fat pad weight ( J:217569 )

• 1.6-fold in visceral (mesenteric, retroperitoneal, and gonadal) white adipose tissue mice fed a high-fat diet

increased retroperitoneal fat pad weight ( J:217569 )

• 1.6-fold in visceral (mesenteric, retroperitoneal, and gonadal) white adipose tissue mice fed a high-fat diet

increased white adipose tissue mass ( J:217569 )

• in mice fed a high-fat diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:217569 )

N • mice fed a high-fat diet exhibit normal glucose sensitivity as similarly treated wild-type mice

increased susceptibility to diet-induced obesity ( J:217569 )

• in mice fed a high-fat diet despite normal food intake

• however, mice fed standard chow exhibit normal weight

impaired adaptive thermogenesis ( J:217569 )

• cold-exposed mice fed a high-fat diet exhibit lower body temperatures compared with wild-type mice

• however, body temperature when housed at 25 degrees Celsius is normal

decreased oxygen consumption ( J:217569 )

• in mice fed a high-fat diet during the light and dark phase

• however, oxygen consumption normalized to lean body mass is normal

immune system

decreased B cell number ( J:217569 )

• in the white adipose tissue of mice fed a high-fat diet

decreased CD4-positive, alpha-beta T cell number ( J:217569 )

• 2.4-fold decrease in the white adipose tissue of mice fed a high-fat diet

increased CD8-positive, alpha-beta T cell number ( J:217569 )

• 2.6-fold increase in the white adipose tissue of mice fed a high-fat diet

abnormal macrophage cell number ( J:217569 )

• increased F4/80+CD11b+CD206-CD11c+ M1 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet

• 2.3-fold decreased F4/80+CD11b+CD206+CD11c- M2 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet

growth/size/body

growth/size/body region phenotype ( J:217569 )

N • mice fed standard chow or a high-fat diet exhibit normal lean mass

increased susceptibility to diet-induced obesity ( J:217569 )

• in mice fed a high-fat diet despite normal food intake

• however, mice fed standard chow exhibit normal weight

hematopoietic system

decreased B cell number ( J:217569 )

• in the white adipose tissue of mice fed a high-fat diet

decreased CD4-positive, alpha-beta T cell number ( J:217569 )

• 2.4-fold decrease in the white adipose tissue of mice fed a high-fat diet

increased CD8-positive, alpha-beta T cell number ( J:217569 )

• 2.6-fold increase in the white adipose tissue of mice fed a high-fat diet

abnormal macrophage cell number ( J:217569 )

• increased F4/80+CD11b+CD206-CD11c+ M1 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet

• 2.3-fold decreased F4/80+CD11b+CD206+CD11c- M2 adipose tissue macrophages in the white adipose tissue of mice fed a high-fat diet

integument

increased subcutaneous adipose tissue amount ( J:217569 )

• 1.8-fold in mice fed a high-fat diet

Genotype
MGI:5296241

cn10

• Allelic Composition: Pnpla2^tm1.1Hsul/Pnpla2^tm1.1Hsul; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

adipose tissue

abnormal brown adipose tissue morphology ( J:176083 )

• pale color

increased brown adipose tissue amount ( J:176083 )

• 4.9-fold

increased brown fat cell size ( J:176083 )

increased white fat cell size ( J:176083 )

increased gonadal fat pad weight ( J:176083 )

• 1.4-fold after 20 weeks on a high fat diet

increased inguinal fat pad weight ( J:176083 )

• 2.0-fold after 20 weeks on a high fat diet

increased renal fat pad weight ( J:176083 )

• 1.9-fold after 20 weeks on a high fat diet

increased total fat pad weight ( J:176083 )

• when fed standard chow

abnormal adipose tissue physiology ( J:176083 )

• under basal and isoproterenol-stimulated conditions, glycerol release and fatty acid release are decreased compared to in wild-type cells

• turnover of triacylglyceride and de novo palmitate is decreased in brown and white adipose tissue compared to in wild-type mice

• brown and white adipose tissue fatty acid oxidation is decreased compared to in wild-type mice

decreased adipocyte glucose uptake ( J:176083 )

• impaired glucose uptake in brown and white adipose tissue

homeostasis/metabolism

decreased fatty acid oxidation ( J:176083 )

• brown and white adipose tissue fatty acid oxidation is decreased compared to in wild-type mice

increased susceptibility to diet-induced obesity ( J:176083 )

• at 12 and 14 weeks when fed a high fat diet

impaired adaptive thermogenesis ( J:176083 )

• in a fasted state with decreased triacylglyceride hydrolase activity

decreased circulating glucose level ( J:176083 )

decreased circulating insulin level ( J:176083 )

abnormal oxygen consumption ( J:176083 )

• in response to the beta3-agonist CL316243, mice fail to exhibit an increase in oxygen consumption unlike similarly treated wild-type mice

decreased oxygen consumption ( J:176083 )

• in fasted mice under cold exposure

increased insulin sensitivity ( J:176083 )

• in the liver with lower diacylglyceride levels

impaired lipolysis ( J:176083 )

• 60% in brown adipose tissue under basal conditions

growth/size/body

increased susceptibility to weight gain ( J:176083 )

• when fed standard chow

increased susceptibility to diet-induced obesity ( J:176083 )

• at 12 and 14 weeks when fed a high fat diet

cellular

decreased adipocyte glucose uptake ( J:176083 )

• impaired glucose uptake in brown and white adipose tissue

decreased fatty acid oxidation ( J:176083 )

• brown and white adipose tissue fatty acid oxidation is decreased compared to in wild-type mice

Genotype
MGI:5696655

cn11

• Allelic Composition: Ppargc1b^tm1.1Javi/Ppargc1b^tm1.1Javi; Tg(Fabp4-cre)1Rev/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

growth/size/body

growth/size/body region phenotype ( J:221221 )

N • no gross abnormalities in body weight or size of major organs

N • diet has no affect on body size in mice raised at 30C

adipose tissue

adipose tissue phenotype ( J:221221 )

N • white adipose tissue weight is normal

N • brown adipose tissue more normal in appearance when mice are raised at 30C

increased brown adipose tissue amount ( J:221221 )

• 50% increase in mass of interscapular brown adipose tissue in mice raised at 21C

abnormal brown fat cell morphology ( J:221221 )

• histological appearance more like white adipose tissue in mice raised at 21C

increased brown fat cell lipid droplet size ( J:221221 )

• large amounts of triglycerides accumulated in a single large vacuole in mice raised at 21C

decreased brown fat lipid droplet number ( J:221221 )

• large amounts of triglycerides accumulated in a single large vacuole in mice raised at 21C

behavior/neurological

behavior/neurological phenotype ( J:221221 )

N • food intake similar to controls

cellular

abnormal mitochondrial physiology ( J:221221 )

• roziglitazone up regulation of mitochondrial gene expression fails

abnormal tricarboxylic acid cycle ( J:221221 )

• many TCA cycle genes are down regulated in white adipose tissue

abnormal respiratory electron transport chain ( J:221221 )

• many respiratory chain enzymes are down regulated in white adipose tissue

abnormal oxidative phosphorylation ( J:221221 )

• many oxidative phosphorylation pathway genes are down regulated

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:221221 )

N • glucose tolerance responses are normal

N • insulin sensitivity is comparable to controls

N • glucose and insulin responses to rosiglitazone are normal

Genotype
MGI:5502687

cn12

• Allelic Composition: Ar^tm1Verh/Y; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

adipose tissue

abnormal adipose tissue amount ( J:196857 )

♂ • while males on a normal chow diet are not obese, they show reduced perigonadal fat weight but increased interscapular brown adipose tissue at 3 months age

♂ • however, body fat composition is no longer different by 6 months of age

♂ • on a high-fat diet, males gain equal weight compared with controls, however after 24 weeks, they have more visceral fat, with increases in omental and mesenteric fat pad weights

increased brown adipose tissue amount ( J:196857 )

♂ • on a normal chow diet, males have an increase in interscapular brown adipose tissue at 3 months of age

♂ • however, white adipose tissue morphology in the perigonadal and subcutaneous depots are normal

decreased gonadal fat pad weight ( J:196857 )

♂ • on a normal chow diet, males have reduced perigonadal fat weight and proportion

increased mesenteric fat pad weight ( J:196857 )

♂ • after 24 weeks of a high-fat diet, males show an increase in mesenteric fat pad weight compared to controls

increased omental fat pad weight ( J:196857 )

♂ • after 24 weeks of a high-fat diet, males show an increase in omental fat pad weight compared to controls

increased interscapular fat pad weight ( J:196857 )

♂ • on a normal chow diet, males have an increase in interscapular brown adipose tissue at 3 months of age

growth/size/body

decreased susceptibility to weight gain ( J:196857 )

♂ • on a normal chow diet, males gain less weight than controls at 3 months of age

homeostasis/metabolism

hyperglycemia ( J:196857 )

♂ • males are euglycemic at 3 months of age, however between 3 and 12 months of age, males are unable to sustain the normal increase in insulin secretory capacity, and they develop hyperglycemia

♂ • after 24 weeks on a high-fat diet, mutants have a poorer secretory response and become more hyperglycemic than controls

increased circulating insulin level ( J:196857 )

♂ • males are euglycemic but hyperinsulinemic both in the fasted state and during glucose tolerance testing at 3 months of age

increased circulating triglyceride level ( J:196857 )

♂ • 3 month old males have elevated plasma triglyceride levels but normal liver triglycerides

impaired glucose tolerance ( J:196857 )

♂ • males show age-related glucose intolerance

insulin resistance ( J:196857 )

♂ • insulin resistance in 3 month old males on a normal diet, as indicated by hyperinsulinemia both in the fasted state and during glucose tolerance

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:196857

Genotype
MGI:3829752

cn13

• Allelic Composition: Rptor^tm1Rueg/Rptor^tm1Rueg; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J

reproductive system

reduced female fertility ( J:143749 )

♀ • female mice produce fewer pups per litter and the time between litters is slightly longer than in control mice that do not express cre

decreased litter size ( J:143749 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:143749 )

N • despite reduced adiposity, mice exhibit normal lipolysis

decreased susceptibility to diet-induced obesity ( J:143749 )

• when fed a high fat diet, mice initially gain more weight than control mice but cease gaining weight after 2 to 3 weeks and over all weight gain is 41% of starting weight compared to 85% in control mice

decreased circulating glucose level ( J:143749 )

• when fed a standard or high fat diet

decreased circulating insulin level ( J:143749 )

• when fed a standard diet

decreased circulating leptin level ( J:143749 )

• when fed a standard or high fat diet

decreased circulating cholesterol level ( J:143749 )

• when fed a high fat diet

increased oxygen consumption ( J:143749 )

• when fed a standard or high fat diet, oxygen consumption in white adipose cells is increased compared to in control cells

improved glucose tolerance ( J:143749 )

• when fed a high fat diet

decreased adiponectin level ( J:143749 )

• when fed a standard or high fat diet

decreased liver triglyceride level ( J:143749 )

• when fed a standard diet, liver triglyceride levels are lower than in control mice

• however, mice fed a high fat diet exhibit normal liver steatosis and liver triglyceride levels

adipose tissue

decreased brown adipose tissue amount ( J:143749 )

• when fed a standard or high fat diet

decreased white fat cell number ( J:143749 )

• when fed a standard or high fat diet

decreased white fat cell size ( J:143749 )

• when fed a high fat diet

decreased total fat pad weight ( J:143749 )

• when fed a standard diet and more pronounced when fed a high fat diet

growth/size/body

increased lean body mass ( J:143749 )

• when fed a standard or high fat diet, mice are leaner than controls

decreased body weight ( J:143749 )

• when fed a standard diet, mice weight 18% less than control mice that do not express cre

decreased susceptibility to diet-induced obesity ( J:143749 )

• when fed a high fat diet, mice initially gain more weight than control mice but cease gaining weight after 2 to 3 weeks and over all weight gain is 41% of starting weight compared to 85% in control mice

behavior/neurological

decreased locomotor activity ( J:143749 )

• when fed a standard diet, mice are less active on a running wheel compared to control mice

• however, mice exhibit normal food intake

digestive/alimentary system

digestive/alimentary phenotype ( J:143749 )

N • despite reduced adiposity, mice exhibit normal lipid absorption

liver/biliary system

decreased liver triglyceride level ( J:143749 )

• when fed a standard diet, liver triglyceride levels are lower than in control mice

• however, mice fed a high fat diet exhibit normal liver steatosis and liver triglyceride levels

Genotype
MGI:3033749

cn14

• Allelic Composition: Pparg^tm2Rev/Pparg^tm2Rev; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6

adipose tissue

abnormal white adipose tissue amount ( J:88210 )

• cell loss greater than 80%

abnormal brown adipose tissue morphology ( J:88210 )

• vacuole form sometimes like white adipose cells rather than typical brown fat cells

decreased brown adipose tissue amount ( J:88210 )

• brown adipose tissue mass reduced more than 70% by 6 months of age

decreased brown fat cell number ( J:88210 )

• cell numbers reduced more than 95%

abnormal brown fat cell size ( J:88210 )

increased brown fat cell size ( J:88210 )

• cells are larger and variable in size

increased white fat cell size ( J:88210 )

• more than 50% of white adipocytes are highly hypertrophic

decreased interscapular fat pad weight ( J:88210 )

• diminution of interscapular fat pads detectable by 4-6 weeks

growth/size/body

slow postnatal weight gain ( J:88210 )

• weight gain on a high fat diet is decreased

enlarged liver ( J:88210 )

• hepatomegaly eventually develops as well

homeostasis/metabolism

increased circulating insulin level ( J:88210 )

• insulin levels are increased

insulin resistance ( J:88210 )

• insulin became less efficient at suppressing glucose production

liver/biliary system

enlarged liver ( J:88210 )

• hepatomegaly eventually develops as well

hepatic steatosis ( J:88210 )

• livers were beginning to be steatotic at 6 months of age

Genotype
MGI:5707240

cn15

• Allelic Composition: Fitm2^tm1.1Dls/Fitm2^tm1.1Dls; Lep^ob/Lep^ob; Tg(Fabp4-cre)1Rev/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Reduced adiposity and unilocular lipid droplets in Fitm2^tm1.1Dls/Fitm2^tm1.1Dls Tg(Fabp4-cre)1Rev/? Lep^ob/Lep^ob mice

growth/size/body

decreased body weight ( J:212437 )

• reduced body weight at 10 weeks relative to homozygous Lep^ob

adipose tissue

decreased subcutaneous adipose tissue amount ( J:212437 )

• at 10 weeks relative to homozygous Lep^ob

decreased white adipose tissue amount ( J:212437 )

• reduced epididymal white adipose tissue at 10 weeks relative to homozygous Lep^ob

• increased macrophage infiltration

integument

decreased subcutaneous adipose tissue amount ( J:212437 )

• at 10 weeks relative to homozygous Lep^ob

Genotype
MGI:5707239

cn16

• Allelic Composition: Fitm2^tm1.1Dls/Fitm2^tm1.1Dls; Tg(Fabp4-cre)1Rev/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Reduced amounts of subcutaneous white adipose tissue and epididmyal white adipose tissue in Fitm2^tm1.1Dls/Fitm2^tm1.1Dls Tg(Fabp4-cre)1Rev/? mice

growth/size/body

growth/size/body region phenotype ( J:212437 )

N • no change in body weight gain over time

increased body weight ( J:212437 )

• weight gain after 10-12 weeks on a high fat diet

increased liver weight ( J:212437 )

• livers weigh 25% more than in controls at 24 weeks of age

• increased liver weights after 12 weeks on a high fat diet

behavior/neurological

behavior/neurological phenotype ( J:212437 )

N • normal food intake

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:212437 )

N • normal plasma leptin levels

N • normal glucose and insulin tolerance

increased circulating tumor necrosis factor level ( J:212437 )

• after 12 weeks on a high fat diet

abnormal glucose homeostasis ( J:212437 )

increased circulating insulin level ( J:212437 )

• hyperinsulinemia at 24 weeks of age

• also after 12 weeks on a high fat diet

insulin resistance ( J:212437 )

• insulin intolerance at 24 weeks of age

abnormal fatty acids level ( J:212437 )

• higher basal and stimulated fatty acid release relative to controls after 12 weeks on a high fat diet

adipose tissue

abnormal brown fat cell morphology ( J:212437 )

increased brown fat cell lipid droplet size ( J:212437 )

decreased brown fat lipid droplet number ( J:212437 )

abnormal white adipose tissue morphology ( J:212437 )

• decreased white adipose tissue at 24 weeks of age

• decreased white adipose tissue after 12 weeks on a high fat diet

• macrophage infiltration of epididymal white adipose tissue

abnormal white fat cell morphology ( J:212437 )

• heterogeneity in adipocyte size after 12 weeks on a high fat diet

• lipid droplets significantly larger 4 days after adipocyte differentiation

• fewer lipid droplets than in controls

abnormal white adipose tissue physiology ( J:212437 )

• massive accumulation of macrophage after 12 weeks on a high fat diet

• indicative of increased adipocyte death

liver/biliary system

increased liver weight ( J:212437 )

• livers weigh 25% more than in controls at 24 weeks of age

• increased liver weights after 12 weeks on a high fat diet

pale liver ( J:212437 )

• after 12 weeks on a high fat diet

immune system

increased circulating tumor necrosis factor level ( J:212437 )

• after 12 weeks on a high fat diet

Genotype
MGI:4943736

cn17

• Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

adipose tissue

abnormal adipose tissue amount ( J:127398 )

decreased brown adipose tissue amount ( J:127398 )

• reduced by more than 65% compared to controls

decreased total body fat amount ( J:127398 )

• difference in body weight is entirely due to the decrease in fat mass

• due to a macroscopically obvious decrease in the interscapular and epididymal fat pads

• increase in fat mass loss when fasted for 24 h

abnormal brown fat cell morphology ( J:127398 )

decreased brown fat cell size ( J:127398 )

decreased brown fat lipid droplet number ( J:127398 )

decreased white fat cell size ( J:127398 )

abnormal fat pad morphology ( J:127398 )

decreased epididymal fat pad weight ( J:127398 )

decreased interscapular fat pad weight ( J:127398 )

abnormal adipose tissue physiology ( J:127398 )

• dramatic decrease in uptake of lipids by adipocytes

• decrease is more dramatic in brown adipose tissue compared to white adipose tissue

growth/size/body

decreased body weight ( J:127398 )

decreased susceptibility to diet-induced obesity ( J:127398 )

• when placed on a high fat diet

increased susceptibility to weight loss ( J:127398 )

• increase in fat mass loss when fasted for 24 h

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:127398 )

N • no difference in respiratory quotients is detected compared to controls

impaired adaptive thermogenesis ( J:127398 )

• core temperature decreases faster when the ambient temperature is lowered compared to similarly exposed controls

decreased circulating leptin level ( J:127398 )

• consistent with the decrease in total body fat amount

decreased body surface temperature ( J:127398 )

• at 22 degrees C core temperature is similar to controls but surface temperature is reduced

• the difference in surface temperature compared to controls becomes more pronounced at 4 degrees C

abnormal body temperature homeostasis ( J:127398 )

• behavioral signs (shivering and trunk curl) indicate impaired ability to maintain body temperature

increased energy expenditure ( J:127398 )

• on normal chow and high fat diets

decreased susceptibility to diet-induced obesity ( J:127398 )

• when placed on a high fat diet

increased oxygen consumption ( J:127398 )

abnormal glucose homeostasis ( J:127398 )

decreased circulating glucose level ( J:127398 )

• markedly lower fasting glucose levels

• fasting glucose levels do not increase even after 16 weeks on a high fat diet

decreased circulating insulin level ( J:127398 )

• markedly lower fasting insulin levels

• fasting insulin levels do not increase even after 16 weeks on a high fat diet

improved glucose tolerance ( J:127398 )

• results indicate that skeletal muscle is responsible for the elevated plasma glucose clearance

abnormal lipid homeostasis ( J:127398 )

abnormal circulating lipid level ( J:127398 )

• postprandial lipid clearance from the circulation in response to a bolus fat load is markedly delayed

decreased circulating free fatty acids level ( J:127398 )

• markedly lower fasting non-esterified fatty acids levels

decreased liver triglyceride level ( J:127398 )

behavior/neurological

increased food intake ( J:127398 )

• despite weighing less, mice consume more food compared to controls

trunk curl ( J:127398 )

• body surface reduction by coiling up that is visible at room temperature (22 degrees C) but becomes more pronounced at 4 degrees C

muscle

increased skeletal muscle cell glucose uptake ( J:127398 )

• enhanced skeletal muscle glucose uptake consistent with the increased muscle activity is seen

liver/biliary system

decreased liver triglyceride level ( J:127398 )

cellular

increased skeletal muscle cell glucose uptake ( J:127398 )

• enhanced skeletal muscle glucose uptake consistent with the increased muscle activity is seen

Genotype
MGI:6107174

cn18

• Allelic Composition: Grb10^tm1.1Fliu/Grb10^tm1.1Fliu; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129S/SvEv

adipose tissue

increased body fat mass ( J:213603 )

• when standard chow despite lean mass

• when fed a high-fat diet despite no increase in food intake

increased brown fat cell size ( J:213603 )

• when fed standard chow or a high-fat diet

whitened brown adipose tissue morphology ( J:213603 )

• brown adipose tissue exhibit larger multilocular lipid droplets compared to in control mice

increased white fat cell size ( J:213603 )

• in epididymal and inguinal white adipose tissues when fed standard chow or a high-fat diet

• however, cell number is normal

abnormal epididymal fat pad morphology ( J:213603 )

• enlarged

growth/size/body

increased body fat mass ( J:213603 )

• when standard chow despite lean mass

• when fed a high-fat diet despite no increase in food intake

increased body weight ( J:213603 )

• at 3 and 6 months

increased susceptibility to age related obesity ( J:213603 )

increased susceptibility to diet-induced obesity ( J:213603 )

• when fed a high-fat diet despite no increase in food intake

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:213603 )

• when fed a high-fat diet despite no increase in food intake

increased circulating insulin level ( J:213603 )

• when fed a high-fat diet

impaired glucose tolerance ( J:213603 )

• when fed a high-fat diet

insulin resistance ( J:213603 )

• when fed a high-fat diet

liver/biliary system

hepatic steatosis ( J:213603 )

• when fed a high-fat diet

Genotype
MGI:3804264

cn19

• Allelic Composition: Stat3^tm1Jbha/Stat3^tm1Jbha; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: 129S/SvEv * C57BL/6

growth/size/body

increased body weight ( J:136030 )

• starting at 9 weeks of age, male mice weigh more than littermate controls

• by 20 weeks of age, male mice have gained 15% more weight than controls

• however, female growth curves remain normal

increased liver weight ( J:136030 )

• liver weight is increased in male mice on an absolute scale but not relative to total body weight

adipose tissue

increased brown adipose tissue amount ( J:136030 )

• male mice have significant increases in brown adipose tissue as measured on an absolute scale and normalized to body weight

increased total body fat amount ( J:136030 )

• weight of fat in grams for male mice is increased compared to control male mice starting at 6 weeks of age

• by 16 weeks of age, the weight of adipose tissue in male mice is almost double that of male control mice

increased fat cell size ( J:136030 )

• adipocytes in male mice have increased cell size

increased gonadal fat pad weight ( J:136030 )

• male mice have significant increases in gonadal fat pad weight as measured on an absolute scale and normalized to body weight

increased inguinal fat pad weight ( J:136030 )

• male mice have significant increases in inguinal fat pad weight as measured on an absolute scale and normalized to body weight

increased retroperitoneal fat pad weight ( J:136030 )

• male mice have significant increases in retroperitoneal fat pad weight as measured on an absolute scale and normalized to body weight

increased percent body fat/body weight ( J:136030 )

• male mice have increased percent body fat starting at 6 weeks of age

homeostasis/metabolism

decreased circulating adiponectin level ( J:136030 )

• serum adiponectin levels are about 20% lower in fasted male mice compared to male controls

liver/biliary system

increased liver weight ( J:136030 )

• liver weight is increased in male mice on an absolute scale but not relative to total body weight

Genotype
MGI:5515332

cn20

• Allelic Composition: Prkar2b^tm3Gsm/Prkar2b^tm2Gsm; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6

behavior/neurological

increased locomotor activity ( J:196157 )

• hyper-locomotor activity is retained

adipose tissue

decreased total body fat amount ( J:196157 )

decreased gonadal fat pad weight ( J:196157 )

• reproductive fat pads weigh significantly less in both males and females

growth/size/body

decreased body weight ( J:196157 )

homeostasis/metabolism

decreased circulating leptin level ( J:196157 )

• low serum leptin levels

Genotype
MGI:5512646

cn21

• Allelic Composition: Tbl1xr1^tm1.1Arte/Tbl1xr1^tm1.1Arte; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:198124 )

• in mice fed a high fat diet

increased circulating leptin level ( J:198124 )

• in mice fed a high fat diet

impaired glucose tolerance ( J:198124 )

• whether mice are fed standard chow or a high fat diet

insulin resistance ( J:198124 )

• whether mice are fed standard chow or a high fat diet

increased liver triglyceride level ( J:198124 )

• in mice fed a high fat diet, but not standard chow

increased skeletal muscle triglyceride level ( J:198124 )

• increased in muscle whether mice are fed standard chow or a high fat diet

impaired lipolysis ( J:198124 )

• in mice fed a high fat diet

muscle

increased skeletal muscle triglyceride level ( J:198124 )

• increased in muscle whether mice are fed standard chow or a high fat diet

adipose tissue

increased total body fat amount ( J:198124 )

• at 14 weeks when fed standard chow

• in mice fed a high fat diet

increased inguinal fat pad weight ( J:198124 )

• in mice fed a high fat diet

increased abdominal fat pad weight ( J:198124 )

• in mice fed a high fat diet

abnormal white adipose tissue morphology ( J:198124 )

• crown-like structures indicating increased damage in mice fed a high fat diet

• impaired fasting-induced fat pad weight reduction

increased white fat cell number ( J:198124 )

• in mice fed a high fat diet, but not standard chow

increased white fat cell size ( J:198124 )

• whether mice are fed standard chow or a high fat diet

abnormal adipose tissue physiology ( J:198124 )

• impaired release of NEFA and glycerol in abdominal white and brown adipose tissue explants in response to beta-adrenoceptor agonist treatment

growth/size/body

increased body weight ( J:198124 )

• at 14 weeks when fed standard chow

• in mice fed a high fat diet

increased susceptibility to diet-induced obesity ( J:198124 )

• in mice fed a high fat diet

liver/biliary system

increased liver triglyceride level ( J:198124 )

• in mice fed a high fat diet, but not standard chow

Genotype
MGI:5567001

cn22

• Allelic Composition: Lep^ob/Lep^ob; Nfe2l2^tm1.1Jgpi/Nfe2l2^tm1.1Jgpi; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:208590 )

N • lipid deposition in the liver and skeletal muscle of mice fed normal chow is the same as in Lep^ob homozygotes

increased circulating glucose level ( J:208590 )

• in mice fed normal chow compared to in Lep^ob homozygotes

increased circulating triglyceride level ( J:208590 )

• in mice fed normal chow compared to in Lep^ob homozygotes

insulin resistance ( J:208590 )

• in mice fed normal chow compared with Lep^ob homozygotes

adipose tissue

decreased white adipose tissue amount ( J:208590 )

• in mice fed normal chow compared to in Lep^ob homozygotes

abnormal white fat cell morphology ( J:208590 )

• fewer small adipocytes in mice fed normal chow compared to in Lep^ob homozygotes

Genotype
MGI:4840474

cn23

• Allelic Composition: Sufu^tm1Hui/Sufu^tm1Hui; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6

adipose tissue

adipose tissue phenotype ( J:166285 )

N • brown adipose tissue is normal

abnormal white adipose tissue morphology ( J:166285 )

decreased subcutaneous adipose tissue amount ( J:166285 )

• subcutaneous white adipose tissue

decreased white adipose tissue amount ( J:166285 )

• reduced white adipose tissue detected by MRI

• particularly perigonadal, mesenteric, and subcutaneous adipose tissue

abnormal white fat cell morphology ( J:166285 )

decreased white fat cell number ( J:166285 )

decreased white fat cell size ( J:166285 )

abnormal white adipose tissue physiology ( J:166285 )

• stromal vascular cell fractions from white adipose tissue cannot be stimulated to differentiate

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:166285 )

N • normal glucose tolerance and insulin sensitivity

integument

decreased subcutaneous adipose tissue amount ( J:166285 )

• subcutaneous white adipose tissue

Genotype
MGI:5515397

cn24

• Allelic Composition: Hdac3^tm1.1Laz/Hdac3^tm1.1Laz; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6

mortality/aging

premature death ( J:199860 )

• no viable adults are obtained; mice are born at the expected Mendelian ratio, but none survive beyond 25 days of age

postnatal lethality, incomplete penetrance ( J:199860 )

• more than 50% die before postnatal day 5 (P5); remaining animals display failure to thrive and a wasting phenotype

growth/size/body

cachexia ( J:199860 )

• animals surviving past P5 fail to thrive and display a wasting phenotype

Genotype
MGI:5505296

cn25

• Allelic Composition: Rala^tm1.2Cjm/Rala^tm1.2Cjm; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6 * C57BL/6J

mortality/aging

mortality/aging ( J:199742 )

N • mice exhibit normal viability

Genotype
MGI:5505298

cn26

• Allelic Composition: Rala^tm1.2Cjm/Rala^tm1.2Cjm; Ralb^tm1.2Cjm/Ralb^tm1.2Cjm; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6 * C57BL/6J

mortality/aging

perinatal lethality, complete penetrance ( J:199742 )

Genotype
MGI:5505297

cn27

• Allelic Composition: Ralb^tm1.2Cjm/Ralb^tm1.2Cjm; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6 * C57BL/6J

mortality/aging

mortality/aging ( J:199742 )

N • mice exhibit normal viability

Genotype
MGI:5305953

cn28

• Allelic Composition: Agt^tm1.1Itl/Agt^tm1.1Itl; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6NTac * SJL

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:178836 )

N • no significant difference in glucose homeostasis compared to controls

decreased circulating angiotensinogen level ( J:178836 )

• in males and females at 2 and 12 months of age compared to control littermates

cardiovascular system

decreased systemic arterial systolic blood pressure ( J:178836 )

• in males and females at 2 and 12 months of age compared to control littermates

adipose tissue

adipose tissue phenotype ( J:178836 )

N • no significant difference in fat mass or adipocyte size compared to controls

growth/size/body

growth/size/body region phenotype ( J:178836 )

N • no significant difference in body weight compared to controls

Genotype
MGI:5468256

cn29

• Allelic Composition: Agtr1a^tm1.1Uky/Agtr1a^tm1.1Uky; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * SJL

adipose tissue

adipose tissue phenotype ( J:192945 )

N • mice fed a high fat diet exhibit normal development of obesity and obesity-associated parameters

abnormal adipose tissue development ( J:192945 )

• decreased differentiation of stromal vascular cell to adipocytes

decreased white fat cell number ( J:192945 )

• in the visceral retroperitoneal and subcutaneous adipose of mice fed a low fat diet

increased white fat cell size ( J:192945 )

• in the visceral retroperitoneal and subcutaneous adipose of mice fed a low fat diet

growth/size/body

growth/size/body region phenotype ( J:192945 )

N • mice fed a high fat diet exhibit normal development of obesity and obesity-associated parameters

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:192945 )

N • mice fed a high fat diet exhibit normal development of obesity and obesity-associated parameters

Genotype
MGI:5660651

cn30

• Allelic Composition: Hmox1^tm1.1Hes/Hmox1^tm1.1Hes; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6J * C57BL/6N

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:214639 )

N • mice fed a high-fat diet exhibit similar body weight accumulation and glucose and insulin tolerance as controls

Genotype
MGI:7610685

cn31

• Allelic Composition: Gpcpd1^{tm1c(EUCOMM)Hmgu}/Gpcpd1^{tm1c(EUCOMM)Hmgu}; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6J * C57BL/6N

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:345630 )

♂ • do not show glucose intolerance at 12 weeks of age

Genotype
MGI:5550143

cn32

• Allelic Composition: Ghr^{tm1c(KOMP)Wtsi}/Ghr^{tm1c(KOMP)Wtsi}; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0125_5_H05

adipose tissue

increased brown adipose tissue amount ( J:206358 )

increased subcutaneous adipose tissue amount ( J:206358 )

increased total body fat amount ( J:206358 )

• at 2 months in male mice

• at 4 months in female mice

increased white fat cell size ( J:206358 )

• in subcutaneous and perigonadal fat pads

increased gonadal fat pad weight ( J:206358 )

♀ • in female, but not male, mice

increased mesenteric fat pad weight ( J:206358 )

increased retroperitoneal fat pad weight ( J:206358 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:206358 )

N • mice exhibit normal glucose homeostasis

increased circulating insulin-like growth factor I level ( J:206358 )

♂ • in male, but not female, mice

increased circulating leptin level ( J:206358 )

♀ • in female, but not male, mice

increased circulating interleukin-6 level ( J:206358 )

♀ • in female, but not male, mice

abnormal fluid regulation ( J:206358 )

• mice exhibit increased fluid mass

decreased circulating adiponectin level ( J:206358 )

♂ • slightly decreased in the serum of male, but not female, mice

growth/size/body

increased lean body mass ( J:206358 )

• at 10 months in male mice

• at 5 to 10 months in female mice

increased body weight ( J:206358 )

• by 3 months in male mice

• by 5 months in female mice

increased kidney weight ( J:206358 )

♀ • in female, but not male, mice

immune system

decreased spleen weight ( J:206358 )

♂ • in male, but not female, mice

increased circulating interleukin-6 level ( J:206358 )

♀ • in female, but not male, mice

renal/urinary system

increased kidney weight ( J:206358 )

♀ • in female, but not male, mice

muscle

increased soleus weight ( J:206358 )

♀ • in female, but not male, mice

integument

increased subcutaneous adipose tissue amount ( J:206358 )

hematopoietic system

decreased spleen weight ( J:206358 )

♂ • in male, but not female, mice

limbs/digits/tail

increased soleus weight ( J:206358 )

♀ • in female, but not male, mice

Genotype
MGI:5487465

cn33

• Allelic Composition: Sqstm1^tm2.1Jmos/Sqstm1^tm2.1Jmos; Tg(Fabp4-cre)1Rev/0
• Genetic Background: Not Specified

Enhanced lipid deposition with increased lipid droplet sizes of brown adipose tissue in Sqstm1^tm2.1Jmos/Sqstm1^tm2.1Jmos Tg(Fabp4-cre)1Rev/0 mice

homeostasis/metabolism

decreased core body temperature ( J:194291 )

• at room temperature and during acute cold exposure

decreased energy expenditure ( J:194291 )

impaired glucose tolerance ( J:194291 )

• in mice fed standard chow but not a high fat diet

insulin resistance ( J:194291 )

• in mice fed standard chow or a high fat diet

adipose tissue

increased total body fat amount ( J:194291 )

• in mice fed standard chow

• however, fat mass is normal in mice fed a high fat diet

increased brown fat cell lipid droplet size ( J:194291 )

increased white fat cell size ( J:194291 )

abnormal brown adipose tissue thermogenesis ( J:194291 )

• impaired nonshivering thermogenesis above brown adipose tissue treated with the selective beta-3 adrenergic receptor agonist CL-316,243

cellular

abnormal mitochondrial crista morphology ( J:194291 )

• fewer and shorter cristae displaced to the periphery with varying degrees of disorientation in the mitochondria of brown adipose tissue

disorganized mitochondrial cristae ( J:194291 )

• in the mitochondria of brown adipose tissue

abnormal mitochondrial ATP synthesis coupled electron transport ( J:194291 )

• decreased oxidative capacity in the mitochondria of brown adipose tissue

growth/size/body

increased lean body mass ( J:194291 )

• in mice fed a high fat diet

• however, lean mass is normal in mice fed standard chow

increased body weight ( J:194291 )

• in mice fed standard chow or a high fat diet

liver/biliary system

hepatic steatosis ( J:194291 )

• in mice fed standard chow or a high fat diet

behavior/neurological

behavior/neurological phenotype ( J:194291 )

N • mice fed standard chow or a high fat diet exhibit normal food intake

decreased locomotor activity ( J:194291 )

• reduced locomotor activity (total and mean dark but not mean light)

Genotype
MGI:3715727

cn34

• Allelic Composition: Ppard^tm1Rev/Ppard^tm1Rev; Tg(Fabp4-cre)1Rev/0
• Genetic Background: Not Specified

adipose tissue

adipose tissue phenotype ( J:73557 )

N • epididymal white and brown interscapular brown fat pads in 4 month-old animals are similar in mutants and controls