Analysis Tools
skeleton
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• females mice have 1.5 times more osteoclasts on bone surface compared to wild-type females
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• osteoclasts are resistant to estrogen induced apoptosis due to a failure to produce fas-ligand
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• females, but not males, have decreased density of the femur
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osteoporosis
(
J:127179
)
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• 12 week old female but not male mice have 1.6 fold loss of trabecular bone volume that is indicative of osteoporosis
• loss of bone volume is not increased upon ovariectomy
• treatment with estrogen fails to rescue the bone loss
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• increased mineral apposition rate in female mice
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• increased bone formation rate in female mice
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• females have increased rates of bone resorption as measured by eroded surface per bone surface
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hematopoietic system
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• females mice have 1.5 times more osteoclasts on bone surface compared to wild-type females
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• osteoclasts are resistant to estrogen induced apoptosis due to a failure to produce fas-ligand
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immune system
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• females mice have 1.5 times more osteoclasts on bone surface compared to wild-type females
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• osteoclasts are resistant to estrogen induced apoptosis due to a failure to produce fas-ligand
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