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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Esr2tm1Mma
targeted mutation 1, Manuel Mark
MGI:2386761
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Esr2tm1Mma/Esr2tm1Mma involves: 129S2/SvPas MGI:3798307
hm2
Esr2tm1Mma/Esr2tm1Mma involves: 129S2/SvPas * C57BL/6 MGI:5298865
ht3
Esr2tm1Mma/Esr2+ involves: 129S2/SvPas MGI:5298866
cx4
Esr1tm1.1Mma/Esr1tm1.1Mma
Esr2tm1Mma/Esr2tm1Mma
involves: 129S2/SvPas * C57BL/6 * SJL MGI:3798305
cx5
Esr1tm1.1Mma/Esr1+
Esr2tm1Mma/Esr2tm1Mma
involves: 129S2/SvPas * C57BL/6 * SJL MGI:3798306
cx6
Esr1tm1.1Mma/Esr1tm1.1Mma
Esr2tm1Mma/Esr2+
involves: 129S2/SvPas * C57BL/6 * SJL MGI:3798308
cx7
ApcMin/Apc+
Esr2tm1Mma/Esr2+
involves: 129S2/SvPas * C57BL/6J MGI:5298868
cx8
ApcMin/Apc+
Esr2tm1Mma/Esr2tm1Mma
involves: 129S2/SvPas * C57BL/6J MGI:5298869


Genotype
MGI:3798307
hm1
Allelic
Composition
Esr2tm1Mma/Esr2tm1Mma
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr2tm1Mma mutation (0 available); any Esr2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• increased gonocytes after birth with decreased gonocyte apoptosis

reproductive system
N
• contrary to previous reports, no hyperplasia of the prostate is observed (J:64426)
• mice exhibit normal numbers of Sertoli and Leydig cells and level of testicular testosterone production (J:105626)
• increased gonocytes after birth with decreased gonocyte apoptosis
• despite normal follicle development, the corpus lutea are scarce or absent
• despite the fertility of male mice, female mice exhibit reduced fertility to infertility
• however, female genital tract morphology is normal

skeleton
N
• mice exhibit normal bone mineral content in the lumbar spine and hind leg and normal bone area and bone mineral density in the midfemur
• slightly
• mice exhibit lower volumetric bone mineral density in the lumbar spine and distal femur compared with wild-type mice
• unloaded and loaded ulna from female mice exhibit increased bone formation measurements compared with wild-type mice
• female mice exhibit increased bone stiffness and mechanical loading compared with wild-type mice
• however, male mice exhibit normal bone stiffness and mechanical loading

homeostasis/metabolism
N
• unlike in previous studies, IGF-I levels are normal
• when treated with gonadotropins to induce superovulation, half of mice failed to ovulate and the other half exhibited reduced yields compared to in similarly treated wild-type mice because follicles reach a preovulatory stage but fail to mature
• ovariectomized mice treated with 17beta-estradiol exhibit delayed wound healing with increased neutrophil infiltration compared with control mice

renal/urinary system
N
• contrary to previous reports, no hyperplasia of the urinary bladder is observed

adipose tissue
• in female, but not male, mice

limbs/digits/tail
• slightly

endocrine/exocrine glands
• despite normal follicle development, the corpus lutea are scarce or absent

hematopoietic system
• in the wounds of ovariectomized mice treated with 17beta-estradiol

immune system
• in the wounds of ovariectomized mice treated with 17beta-estradiol




Genotype
MGI:5298865
hm2
Allelic
Composition
Esr2tm1Mma/Esr2tm1Mma
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr2tm1Mma mutation (0 available); any Esr2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in an elevated plus maze, female mice exhibit fewer time in open arms and head dips compared with wild-type mice
• however, male mice exhibit normal anxiety-related behavior
• in female mice in an open field
• in female mice in an open field
• in female mice in an open field
• in ovariectomized female mice during the interphase and early tonic phase II of the formalin test but not during acute and late tonic phases

nervous system
• female mice exhibit reduced threshold for the induction of synaptic plasticity in the basolateral amygdala compared with wild-type mice




Genotype
MGI:5298866
ht3
Allelic
Composition
Esr2tm1Mma/Esr2+
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr2tm1Mma mutation (0 available); any Esr2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• mice exhibit normal numbers of Sertoli and Leydig cells and level of testicular testosterone production
• increased gonocytes after birth with decreased gonocyte apoptosis

cellular
• increased gonocytes after birth with decreased gonocyte apoptosis




Genotype
MGI:3798305
cx4
Allelic
Composition
Esr1tm1.1Mma/Esr1tm1.1Mma
Esr2tm1Mma/Esr2tm1Mma
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1tm1.1Mma mutation (0 available); any Esr1 mutation (68 available)
Esr2tm1Mma mutation (0 available); any Esr2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice exhibit large, hemorrhagic cysts originating from antral follicles

reproductive system
• in the seminiferous tubules
• unlike in wild-type mice, follicles exhibit a marked deficiency in granulosa cells
• the largest antral follicles exhibit very thin walls due to the absence of granulosa cells
• mice exhibit a reduction in the number of glandular interstitial cells compared to wild-type mice and these cells appear loosely arranged as a consequence of edema
• mice exhibit the presence of mast-like cells in the ovaries unlike wild-type mice
• ovaries contain fully differentiated Sertoli cells
• however, female mice do not exhibit an increase in anti-Mullerian hormone
• however, primordial, and primary follicles are normal
• Sertoli cells develop between ovarian follicles after the onset of puberty and appear to arise within the epithelium of atretic follicles
• mice exhibit an excess of follicles at advanced stages of atresia
• the largest antral follicles exhibit very thin walls due to the absence of granulosa cells
• unlike in wild-type mice, prepubertal antral follicles are surrounded by a single layer or loosely packed organization of granulosa cells and a single layer of theca cells, and contain a suspended oocyte completely detached from the follicular wall
• theca cell proliferation is decreased compared to in wild-type mice
• mice exhibit large, hemorrhagic cysts originating from antral follicles
• mice exhibit a straightening of the rete testis unlike wild-type mice
• mice exhibit a straightening of the seminiferous tubules unlike wild-type mice
• ovaries contain fully differentiated Sertoli cells
• Sertoli cells in the ovaries develop between ovarian follicles after the onset of puberty and appear to arise within the epithelium of atretic follicles
• despite normal genital tract anterior-posterior development, mice exhibit a 2-fold reduction in uterus diameter and wall thickness
• mice exhibit a reduction in cell number and size that affects all tissue types
• despite normal genital tract anterior-posterior development, mice exhibit a 2-fold reduction in vagina diameter and wall thickness
• mice exhibit hypoplastic vaginas with a reduction in both cell number and size that affects all tissue types

homeostasis/metabolism
• mice fail to superovulate when treated with gonadotropins and follicles fail to even reach the preovulatory stage unlike in similarly treated wild-type mice

endocrine/exocrine glands
• unlike in wild-type mice, follicles exhibit a marked deficiency in granulosa cells
• the largest antral follicles exhibit very thin walls due to the absence of granulosa cells
• mice exhibit a reduction in the number of glandular interstitial cells compared to wild-type mice and these cells appear loosely arranged as a consequence of edema
• mice exhibit the presence of mast-like cells in the ovaries unlike wild-type mice
• ovaries contain fully differentiated Sertoli cells
• however, female mice do not exhibit an increase in anti-Mullerian hormone
• however, primordial, and primary follicles are normal
• Sertoli cells develop between ovarian follicles after the onset of puberty and appear to arise within the epithelium of atretic follicles
• mice exhibit an excess of follicles at advanced stages of atresia
• the largest antral follicles exhibit very thin walls due to the absence of granulosa cells
• unlike in wild-type mice, prepubertal antral follicles are surrounded by a single layer or loosely packed organization of granulosa cells and a single layer of theca cells, and contain a suspended oocyte completely detached from the follicular wall
• theca cell proliferation is decreased compared to in wild-type mice
• mice exhibit large, hemorrhagic cysts originating from antral follicles
• mice exhibit a straightening of the rete testis unlike wild-type mice
• mice exhibit a straightening of the seminiferous tubules unlike wild-type mice
• ovaries contain fully differentiated Sertoli cells
• Sertoli cells in the ovaries develop between ovarian follicles after the onset of puberty and appear to arise within the epithelium of atretic follicles

cellular
• in the seminiferous tubules
• unlike in wild-type mice, follicles exhibit a marked deficiency in granulosa cells
• the largest antral follicles exhibit very thin walls due to the absence of granulosa cells




Genotype
MGI:3798306
cx5
Allelic
Composition
Esr1tm1.1Mma/Esr1+
Esr2tm1Mma/Esr2tm1Mma
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1tm1.1Mma mutation (0 available); any Esr1 mutation (68 available)
Esr2tm1Mma mutation (0 available); any Esr2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• unlike in wild-type mice, follicles exhibit a marked deficiency in granulose cells
• mice exhibit increased antral follicle numbers compared to in wild-type mice
• however, no cysts form and interstitial glandular cell organization is normal
• despite the fertility of male mice, female mice exhibit reduced fertility to infertility

homeostasis/metabolism
• mice fail to superovulate when treated with gonadotropins because follicles reach a preovulatory stage but fail to mature unlike in similarly treated wild-type mice

endocrine/exocrine glands
• unlike in wild-type mice, follicles exhibit a marked deficiency in granulose cells
• mice exhibit increased antral follicle numbers compared to in wild-type mice
• however, no cysts form and interstitial glandular cell organization is normal

cellular
• unlike in wild-type mice, follicles exhibit a marked deficiency in granulose cells




Genotype
MGI:3798308
cx6
Allelic
Composition
Esr1tm1.1Mma/Esr1tm1.1Mma
Esr2tm1Mma/Esr2+
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1tm1.1Mma mutation (0 available); any Esr1 mutation (68 available)
Esr2tm1Mma mutation (0 available); any Esr2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• superovulation induced by gonadotropin treatment is severely reduced compared to in wild-type mice




Genotype
MGI:5298868
cx7
Allelic
Composition
ApcMin/Apc+
Esr2tm1Mma/Esr2+
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Esr2tm1Mma mutation (0 available); any Esr2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• while tumor progression is stimulated to a greater extent than in Apcmin heterozygotes, tumor initiation is the same
• mice develop increased tumors in the small and large intestines, including the cecum and one third of the colons, compared with Apcmin heterozygotes
• mice develop sessile and pedunculated forms of colonic adenomas unlike Apcmin heterozygotes

digestive/alimentary system
• increased proliferation of cells in the colon in ovariectomized
• mice develop increased tumors in the small and large intestines, including the cecum and one third of the colons, compared with Apcmin heterozygotes
• mice develop sessile and pedunculated forms of colonic adenomas unlike Apcmin heterozygotes
• while tumor progression is stimulated to a greater extent than in Apcmin heterozygotes, tumor initiation is the same

cellular
• increased proliferation of cells in the colon in ovariectomized




Genotype
MGI:5298869
cx8
Allelic
Composition
ApcMin/Apc+
Esr2tm1Mma/Esr2tm1Mma
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Esr2tm1Mma mutation (0 available); any Esr2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• fewer mature goblet cells in the colon with prevalent pregoblet cells
• increased proliferation of cells in the colon
• mice develop increased tumors in the large intestine, including the cecum and one third of the colons, compared with Apcmin heterozygotes
• mice develop sessile and pedunculated forms of colonic adenomas unlike Apcmin heterozygotes
• while tumor progression is stimulated to a greater extent than in Apcmin heterozygotes, tumor initiation is the same
• mononuclear cell infiltrates in the colon

neoplasm
• mice develop increased tumors in the large intestine, including the cecum and one third of the colons, compared with Apcmin heterozygotes
• mice develop sessile and pedunculated forms of colonic adenomas unlike Apcmin heterozygotes
• while tumor progression is stimulated to a greater extent than in Apcmin heterozygotes, tumor initiation is the same

immune system
• mononuclear cell infiltrates in the colon

cellular
• fewer mature goblet cells in the colon with prevalent pregoblet cells
• increased proliferation of cells in the colon

endocrine/exocrine glands
• fewer mature goblet cells in the colon with prevalent pregoblet cells





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory