About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gata4tm1Sho
targeted mutation 1, Stuart Orkin
MGI:2386764
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gata4tm1Sho/Gata4tm1Sho involves: 129S6/SvEvTac MGI:2665406
ht2
 		Gata4tm1Sho/Gata4+ C57BL/6JEi-Chr YA/HeJ/EiJ MGI:6479102
cn3
 		Gata4tm1Sho/Gata4+
Tg(Myh6-cre)2182Mds/0 		involves: 129S6/SvEvTac MGI:3851413
cn4
 		Gata4tm1Sho/Gata4+
Nkx2-5tm1(cre)Rjs/Nkx2-5+ 		involves: 129S6/SvEvTac * 129S7/SvEvBrd MGI:3851410
cn5
 		Gata4tm1Sho/Gata4tm1.1Wtp
Tg(Myh6-cre)2182Mds/0 		involves: 129S6/SvEvTac * 129S7/SvEvBrd MGI:3851409
cn6
 		Gata4tm1Sho/Gata4tm1.1Wtp
Nkx2-5tm1(cre)Rjs/Nkx2-5+ 		involves: 129S6/SvEvTac * 129S7/SvEvBrd MGI:3851408
cx7
 		Gata4tm1Sho/Gata4tm1Sho
Gata6tm1Kgac/Gata6tm1Kgac 		involves: 129S1/Sv * 129S6/SvEvTac MGI:3789027


Genotype
MGI:2665406
hm1
Allelic
Composition		 Gata4tm1Sho/Gata4tm1Sho
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Sho mutation (0 available); any Gata4 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
abnormal truncus arteriosus septation ( J:77392 )
• pulmonary and aortic outflow tracts comingle
abnormal conotruncal ridge morphology ( J:77392 )
• endocardial cushion cells of both pulmonary and aortic outflow tracts appear more numerous
absent coronary vessels ( J:77392 )
• absence of coronary vasculature
common atrioventricular valve ( J:77392 )
• exhibit a common atroventricular valve situated between the left and right ventricles that has no fibrous continuity with the aortic valve
dilated heart atrium ( J:77392 )
• right and left atria are massively dilated and freely communicate
ventricular septal defect ( J:77392 )
• providing the only outlet from the left ventricle
hemorrhage ( J:77392 )
• often observe peripheral hemorrhage

reproductive system
abnormal Sertoli cell morphology ( J:78688 )
• blocked differentiation
abnormal fetal Leydig cell differentiation ( J:78688 )
• maturation of leydig cells was not initiated
primary sex reversal ( J:78688 )
• gonads of XY mice develop as ovaries
• XX mice develop abnormal ovaries

respiratory system
abnormal lung development ( J:134027 )
• lungs cultured from E11.5 embryos lack accessory lobe and accessory bud development and show a mild growth delay

homeostasis/metabolism

endocrine/exocrine glands
abnormal Sertoli cell morphology ( J:78688 )
• blocked differentiation
abnormal fetal Leydig cell differentiation ( J:78688 )
• maturation of leydig cells was not initiated

integument

muscle




Genotype
MGI:6479102
ht2
Allelic
Composition		 Gata4tm1Sho/Gata4+
Genetic
Background		 C57BL/6JEi-Chr YA/HeJ/EiJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Sho mutation (0 available); any Gata4 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
primary sex reversal ( J:125196 )
• Background Sensitivity: heterozygous carriers with the A/HeJ Y Chromosome on the C57BL/6JEi background develop ovaries




Genotype
MGI:3851413
cn3
Allelic
Composition		 Gata4tm1Sho/Gata4+
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Sho mutation (0 available); any Gata4 mutation (36 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:150452 )
N
• animals show normal development




Genotype
MGI:3851410
cn4
Allelic
Composition		 Gata4tm1Sho/Gata4+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Sho mutation (0 available); any Gata4 mutation (36 available)
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:150452 )
N
• animals show normal development




Genotype
MGI:3851409
cn5
Allelic
Composition		 Gata4tm1Sho/Gata4tm1.1Wtp
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Wtp mutation (0 available); any Gata4 mutation (36 available)
Gata4tm1Sho mutation (0 available); any Gata4 mutation (36 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Reduced coronary microvasculature, decreased capillary density and increased fibrosis in Gata4tm1.1Wtp/Gata4tm1Sho Tg(Myh6-cre)2182Mds/0 hearts

cardiovascular system
dilated heart ventricle ( J:150452 )
• ventricular dilation is observed
abnormal cardiovascular system physiology ( J:150452 )
• severely diminished systolic function at 8-14 weeks




Genotype
MGI:3851408
cn6
Allelic
Composition		 Gata4tm1Sho/Gata4tm1.1Wtp
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1.1Wtp mutation (0 available); any Gata4 mutation (36 available)
Gata4tm1Sho mutation (0 available); any Gata4 mutation (36 available)
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Edema, peripheral hemorrhage, and reduced coronary plexus in Gata4tm1.1Wtp/Gata4tm1Sho Nkx2-5tm1(cre)Rjs/Nkx2-5+ embryos and enlarged dilated ventricles and increased fibrosis in Gata4tm1.1Wtp/Gata4tm1Sho Tg(Myh6-cre)2182Mds/0 hearts

cardiovascular system
thin myocardium compact layer ( J:150452 )
• compact myocardium is thin
abnormal atrioventricular cushion morphology ( J:150452 )
• atrio-ventricular cushion defect is observed
abnormal coronary vessel morphology ( J:150452 )
• coronary vascular development is impaired
ventricular septal defect ( J:150452 )
• ventricular septal defect is observed
hemorrhage ( J:150452 )
• peripheral hemorrhage is observed at E13.5

homeostasis/metabolism
skin edema ( J:150452 )
• observed at E13.5

integument
skin edema ( J:150452 )
• observed at E13.5

muscle
thin myocardium compact layer ( J:150452 )
• compact myocardium is thin




Genotype
MGI:3789027
cx7
Allelic
Composition		 Gata4tm1Sho/Gata4tm1Sho
Gata6tm1Kgac/Gata6tm1Kgac
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Sho mutation (0 available); any Gata4 mutation (36 available)
Gata6tm1Kgac mutation (0 available); any Gata6 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal lung development ( J:134027 )
• lungs cultured from E11.5 embryos lack accessory lobe and accessory bud development and show a mild growth delay
• the phenotype of double mutants is not more severe than that of Gata4 single homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory