Phenotypes associated with this allele

• Allele Symbol: Cnmd^tm1Ref
• Allele Name: targeted mutation 1, Reinhard Fassler
• Allele ID: MGI:2386777
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cnmd^tm1Ref/Cnmd^tm1Ref	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2668196
cx2	Cnmd^tm1Ref/Cnmd^tm1Ref Tnmd^tm1Ref/Tnmd^tm1Ref	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3530626

Genotype
MGI:2668196

hm1

• Allelic Composition: Cnmd^tm1Ref/Cnmd^tm1Ref
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:78596 )

• homozygotes are viable and fertile and exhibit normal cartilage development and enchondral bone formation, with no detectable differences in the onset of primary ossification, in vascular invasion, or in proliferation of chondrocytes relative to wild-type littermates

• surprisingly, no compensatory upregulation of tenomodulin (a close homologue also known as tendin), or other angiogenic or antiangiogenic factors is observed

• in addition, homozygotes display normal eye development with no evidence of pathological vascularization, as well as normal thymus development with no differences in the cortex/matrix proportion or thymic vessel density relative to wild-type littermates

Genotype
MGI:3530626

cx2

• Allelic Composition: Cnmd^tm1Ref/Cnmd^tm1Ref; Tnmd^tm1Ref/Tnmd^tm1Ref
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

vision/eye

vision/eye phenotype ( J:96005 )

♀N • retinas and retinal vasculature of double homozygotes showed no differences from wild-type under normal conditions or after oxygen-induced retinopathy