Phenotypes associated with this allele

• Allele Symbol: Igtp^tm1Gvw
• Allele Name: targeted mutation 1, George F Vande Woude
• Allele ID: MGI:2386795
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igtp^tm1Gvw/Igtp^tm1Gvw	involves: 129S1/Sv * C57BL/6	MGI:3603452

Genotype
MGI:3603452

hm1

• Allelic Composition: Igtp^tm1Gvw/Igtp^tm1Gvw
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:59891 )

N • mice display normal defense against L. monocytogenes and MCMV

increased circulating interferon-gamma level ( J:59891 )

• serum IFN gamma levels are slightly elevated after T. gondii infection

increased circulating interleukin-12b level ( J:59891 )

• serum Il12p40 levels are slightly elevated after T. gondii infection

increased susceptibility to parasitic infection ( J:59891 , J:99144 )

• severely compromised response to infection by Toxoplasma gondii (J:59891)

• growth suppressing activity of bone marrow macrophage against T. gondii reduced relative to controls (J:99144)

homeostasis/metabolism

increased circulating interferon-gamma level ( J:59891 )

• serum IFN gamma levels are slightly elevated after T. gondii infection

increased circulating interleukin-12b level ( J:59891 )

• serum Il12p40 levels are slightly elevated after T. gondii infection