Phenotypes associated with this allele

• Allele Symbol: Mttp^tm1Chan
• Allele Name: targeted mutation 1, Lawrence Chan
• Allele ID: MGI:2386838
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mttp^tm1Chan/Mttp^tm1Chan	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3628963

Genotype
MGI:3628963

cn1

• Allelic Composition: Mttp^tm1Chan/Mttp^tm1Chan
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating cholesterol level ( J:53390 )

• homozygotes on a high cholesterol diet injected with an adenovirus carrying the Cre1 recombinse (Ad-Cre1) to delete the floxed region in the liver, show a significant reduction in plasma cholesterol

decreased circulating HDL cholesterol level ( J:53390 )

• homozygotes fed a chow or high cholesterol diet that were injected with Ad-Cre1 show a marked or slight reduction, respectively, in the HDL fraction

decreased circulating LDL cholesterol level ( J:53390 )

• homozygotes fed a chow or high cholesterol diet that were injected with Ad-Cre1 show an almost complete absence of lipoproteins in the IDL/LDL fraction

decreased circulating VLDL cholesterol level ( J:53390 )

• homozygotes fed a chow or high cholesterol diet that were injected with Ad-Cre1 show an almost complete absence of lipoproteins in the VLDL fraction

abnormal triglyceride level ( J:53390 )

• homozygotes fed a fat-free diet that were injected with AD-Cre1 show a triglyceride secretion rate that is reduced to less than 1/10 that in wild-type

decreased circulating VLDL triglyceride level ( J:53390 )

• homozygotes fed a chow or high cholesterol diet that were injected with Ad-Cre1 show an essentially abolished VLDL region