Phenotypes associated with this allele

• Allele Symbol: Mesp2^{tm5(Notch1)Ysa}
• Allele Name: targeted mutation 5, Yumiko Saga
• Allele ID: MGI:2386850
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mesp2^tm5(Notch1)Ysa/Mesp2^tm5(Notch1)Ysa	involves: C57BL/6 * CBA	MGI:3715286
cx2	Mesp2^tm5(Notch1)Ysa/Mesp2^tm5(Notch1)Ysa Psen1^tm1Shs/Psen1^tm1Shs	involves: C57BL/6 * CBA	MGI:3715289

Genotype
MGI:3715286

hm1

• Allelic Composition: Mesp2^{tm5(Notch1)Ysa}/Mesp2^{tm5(Notch1)Ysa}
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal vertebral arch morphology ( J:78989 )

• mice have the same skeletal defects as Mesp2^tm4Ysa homozygotes

Genotype
MGI:3715289

cx2

• Allelic Composition: Mesp2^{tm5(Notch1)Ysa}/Mesp2^{tm5(Notch1)Ysa}; Psen1^tm1Shs/Psen1^tm1Shs
• Genetic Background: involves: C57BL/6 * CBA

skeleton

abnormal vertebral arch morphology ( J:78989 )

• the metameric appearance of the axial skeleton is partially restored compared to Psen1^tm1Hko homozygotes

• ossicification centers of the pedicles are not completely fused and are irregularly segmented