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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Blktm1Tara
targeted mutation 1, Alexander Tarakhovsky
MGI:2386868
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Blktm1Tara/Blktm1Tara involves: 129P2/OlaHsd MGI:2658678
cx2
 		Blktm1Tara/Blktm1Tara
Fyntm1Sor/Fyntm1Sor
Lyntm1Ard/Lyntm1Ard 		either: B6.129-Lyntm1Ard Fyntm1Sor Blktm1Tara or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) MGI:3696475


Genotype
MGI:2658678
hm1
Allelic
Composition		 Blktm1Tara/Blktm1Tara
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blktm1Tara mutation (1 available); any Blk mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:60221 )
• homozygous mice exhibit no discernable phenotype; mice are viable and fertile with normal B cell development and immune responses




Genotype
MGI:3696475
cx2
Allelic
Composition		 Blktm1Tara/Blktm1Tara
Fyntm1Sor/Fyntm1Sor
Lyntm1Ard/Lyntm1Ard
Genetic
Background		 either: B6.129-Lyntm1Ard Fyntm1Sor Blktm1Tara or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blktm1Tara mutation (1 available); any Blk mutation (28 available)
Fyntm1Sor mutation (3 available); any Fyn mutation (39 available)
Lyntm1Ard mutation (6 available); any Lyn mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:115080 )
• mutant bone marrow is unable to reconstitute B cell development when transferred into lethally irradiated C57BL/6 mice
decreased immature B cell number ( J:115080 )
• exhibit a decrease in immature and B cells in the bone marrow
abnormal pro-B cell differentiation ( J:115080 )
• pro-B cells exhibit impaired anti-Igbeta-induced NF-kappaB activation
arrested B cell differentiation ( J:115080 )
• block in early B cell development
decreased B cell number ( J:115080 )
• impaired development of B cells results in severe B cell lymphopenia characterized by a decrease in B cell numbers in the spleen, lymph nodes, and peritoneal cavity to 1/60-1/100 of wild-type
decreased pre-B cell number ( J:115080 )
• exhibit a reduction in the fraction of viable B220+CD43-IgM- pre-B cells to 10% of wild-type
• 3-fold increase in frequency of apoptotic pre-B cells

hematopoietic system
abnormal B cell differentiation ( J:115080 )
• mutant bone marrow is unable to reconstitute B cell development when transferred into lethally irradiated C57BL/6 mice
decreased immature B cell number ( J:115080 )
• exhibit a decrease in immature and B cells in the bone marrow
abnormal pro-B cell differentiation ( J:115080 )
• pro-B cells exhibit impaired anti-Igbeta-induced NF-kappaB activation
arrested B cell differentiation ( J:115080 )
• block in early B cell development
decreased B cell number ( J:115080 )
• impaired development of B cells results in severe B cell lymphopenia characterized by a decrease in B cell numbers in the spleen, lymph nodes, and peritoneal cavity to 1/60-1/100 of wild-type
decreased pre-B cell number ( J:115080 )
• exhibit a reduction in the fraction of viable B220+CD43-IgM- pre-B cells to 10% of wild-type
• 3-fold increase in frequency of apoptotic pre-B cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory