Phenotypes associated with this allele

• Allele Symbol: Sdc4^tm1Tmu
• Allele Name: targeted mutation 1, Takashi Muramatsu
• Allele ID: MGI:2386875
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sdc4^tm1Tmu/Sdc4^tm1Tmu	B6.129S2-Sdc4^tm1Tmu	MGI:3851802
hm2	Sdc4^tm1Tmu/Sdc4^tm1Tmu	involves: 129S2/SvPas	MGI:6364851
hm3	Sdc4^tm1Tmu/Sdc4^tm1Tmu	involves: 129S2/SvPas * C57BL/6J	MGI:3851801

Genotype
MGI:3851802

hm1

• Allelic Composition: Sdc4^tm1Tmu/Sdc4^tm1Tmu
• Genetic Background: B6.129S2-Sdc4^tm1Tmu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:68843 , J:131075 )

• following ip injection of kappa-carrageenan at 75 mg/kg, 7 of 24 (29.2%) of mice die within 7 days compared to none of 24 similarly treated wild-type controls (J:68843)

• increased incidence of death following treatment with concanavalin-A compared to similarly treated wild-type controls (J:131075)

embryo

abnormal placental labyrinth vasculature morphology ( J:65874 )

• at E17.5 degeneration of vessels is more diffuse and occurs over a larger area compared to wild-type controls

homeostasis/metabolism

increased blood urea nitrogen level ( J:68843 )

• on days 1 and 4 following ip injection of kappa-carrageenan at 75 mg/kg, surviving mice exhibit significantly higher BUN levels than similarly treated wild-type controls

increased susceptibility to xenobiotic induced morbidity/mortality ( J:68843 , J:131075 )

• following ip injection of kappa-carrageenan at 75 mg/kg, 7 of 24 (29.2%) of mice die within 7 days compared to none of 24 similarly treated wild-type controls (J:68843)

• increased incidence of death following treatment with concanavalin-A compared to similarly treated wild-type controls (J:131075)

increased physiological sensitivity to xenobiotic ( J:68843 , J:131075 )

• following ip injection of kappa-carrageenan at 75 mg/kg, mice exhibit more severe renal damage and dysfunction compared to similarly treated wild-type controls (J:68843)

• however, renal damage induced by cisplatin, bromoethylamine hydrobromide, or glycerol is similar to wild-type controls (J:68843)

• increased severity of concanavalin-A induced hepatic injury compared to similarly treated wild-type controls (J:131075)

renal/urinary system

abnormal kidney inner medulla morphology ( J:68843 )

• on days 2 following ip injection of kappa-carrageenan at 75 mg/kg, mice exhibit extensive deposition of kappa-carrageenan in the inner medulla compared with similarly treated wild-type controls

dilated renal tubule ( J:68843 )

• on days 1 and 4 following ip injection of kappa-carrageenan at 75 mg/kg, surviving mice exhibit more extensive and severe renal tubule dilation than similarly treated wild-type controls

kidney degeneration ( J:68843 )

• on days 1 and 4 following ip injection of kappa-carrageenan at 75 mg/kg, mice exhibit more extensive and severe inner medulla degeneration than similarly treated wild-type controls

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:65874 )

• at E17.5 degeneration of vessels is more diffuse and occurs over a larger area compared to wild-type controls

Genotype
MGI:6364851

hm2

• Allelic Composition: Sdc4^tm1Tmu/Sdc4^tm1Tmu
• Genetic Background: involves: 129S2/SvPas

cardiovascular system

cardiovascular system phenotype ( J:276769 )

N • mice exhibit normal retinal vasculature and response to common femoral artery ligation

Genotype
MGI:3851801

hm3

• Allelic Composition: Sdc4^tm1Tmu/Sdc4^tm1Tmu
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

cellular

abnormal cell adhesion ( J:60596 )

• impaired focal adhesion formation in fibroblasts treated with cycloheximide and cultured on coverslips coated with the cell binding fragment of fibronectin and with the heparin binding fragment of fibronectin added to the media