All Phenotypes Chek2<tm1Mak> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Chek2^tm1Mak
targeted mutation 1, Tak Mak
MGI:2386905

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chek2^tm1Mak/Chek2^tm1Mak	involves: 129P2/OlaHsd	MGI:3761094
hm2	Chek2^tm1Mak/Chek2^tm1Mak	involves: 129P2/OlaHsd * C57BL/6	MGI:2662578
cn3	Brca1^tm2Mak/Brca1^tm2Mak Chek2^tm1Mak/Chek2^tm1Mak Tg(Lck-cre)548Jxm/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3834734
cn4	Brca1^tm2Mak/Brca1^tm2Mak Chek2^tm1Mak/Chek2^tm1Mak Tg(Wap-cre)11738Mam/?	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL	MGI:3834736
cx5	Chek2^tm1Mak/Chek2⁺ Rad50^tm2Jpt/Rad50^tm2Jpt	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:3615685
cx6	Chek2^tm1Mak/Chek2^tm1Mak Rad50^tm2Jpt/Rad50^tm2Jpt	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:3615684
cx7	Cep63^{Gt(EUCE0251h11)Hmgu}/Cep63^{Gt(EUCE0251h11)Hmgu} Chek2^tm1Mak/Chek2^tm1Mak	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	MGI:5819197
cx8	Chek2^tm1Mak/Chek2^tm1Mak Swsap1^em1Mjn/Swsap1^em1Mjn	involves: 129P2/OlaHsd * C57BL/6J * CBA/J	MGI:6287688
cx9	Chek2^tm1Mak/Chek2^tm1Mak Zswim7^em1Mjn/Zswim7^em1Mjn	involves: 129P2/OlaHsd * C57BL/6J * CBA/J	MGI:6287690

Allelic Composition	Chek2^tm1Mak/Chek2^tm1Mak
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek2^tm1Mak mutation (1 available); any Chek2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cellular sensitivity to ionizing radiation ( J:126186 )

• mouse embryonic fibroblast cells fail to undergo apoptosis following exposure to ionizing radiation as do wild-type cells

• however, mouse embryonic fibroblast cells arrest in G1 phase following exposure to ionizing radiation unlike Trp53 null cells and similar to wild-type cells

Allelic Composition	Chek2^tm1Mak/Chek2^tm1Mak
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek2^tm1Mak mutation (1 available); any Chek2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:78491 )

• incidence of 7,12-dimethylbenzanthracene (DMBA)-induced skin tumors is enhanced, however mutants do not develop spontaneous tumors by 1 year of age

• onset of DMBA-induced skin tumors occurs earlier than in wild-type

cellular

abnormal cell cycle checkpoint function ( J:78491 )

• mouse embryonic fibroblasts (MEFs) fail to arrest at G1 at low ionizing radiation (IR) doses but behave normally at higher doses

• mutants exposed to IR radiation exhibit a shorter duration of the G2/M checkpoint in the epidermis than wild-type, with mitosis resuming by 24 hours post-IR

• gamma-irradiated thymic cells show a partial defect in G1/S-phase checkpoint, with a milder G1 arrest than observed in Trp53 and Atm mutants

decreased cellular sensitivity to gamma-irradiation ( J:78491 )

• cells from thymus, CNS, hair follicles, and fibroblasts are resistant to gamma irradiation-induced apoptosis

• unlike wild-type epidermal cells that show a reduction in proliferation 24 hours post IR irradiation, mutant epidermal cells exhibit no reduction in proliferation

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:78491 )

• incidence of 7,12-dimethylbenzanthracene (DMBA)-induced skin tumors is enhanced, however mutants do not develop spontaneous tumors by 1 year of age

• onset of DMBA-induced skin tumors occurs earlier than in wild-type

Allelic Composition	Brca1^tm2Mak/Brca1^tm2Mak Chek2^tm1Mak/Chek2^tm1Mak Tg(Lck-cre)548Jxm/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1^tm2Mak mutation (1 available); any Brca1 mutation (113 available)
Chek2^tm1Mak mutation (1 available); any Chek2 mutation (53 available)
Tg(Lck-cre)548Jxm mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:90512 )

• 32% with lymphomas by 180 days of age

• tumors are restricted to the thymus

immune system

immune system phenotype ( J:90512 )

N	• complete thymocyte restoration • T cell numbers in the periphery are restored

cellular

cellular phenotype ( J:90512 )

N	• resistant to gamma irradiation • restoration of normal cell cycle arrest of T cells when stimulated with antibody to CD3e or CD3 and Il2

chromosomal instability ( J:90512 )

• increased frequency

neoplasm

increased T cell derived lymphoma incidence ( J:90512 )

• 32% with lymphomas by 180 days of age

• tumors are restricted to the thymus

Allelic Composition	Brca1^tm2Mak/Brca1^tm2Mak Chek2^tm1Mak/Chek2^tm1Mak Tg(Wap-cre)11738Mam/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:90512 )

• about 50% develop acinar adenocarcenomas

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:90512 )

• about 50% develop acinar adenocarcenomas

integument

increased mammary adenocarcinoma incidence ( J:90512 )

• about 50% develop acinar adenocarcenomas

Allelic Composition	Chek2^tm1Mak/Chek2⁺ Rad50^tm2Jpt/Rad50^tm2Jpt
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek2^tm1Mak mutation (1 available); any Chek2 mutation (53 available)
Rad50^tm2Jpt mutation (0 available); any Rad50 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:103922 )

• 31 of 41 die by 5 months of age

hematopoietic system

abnormal pro-B cell morphology ( J:103922 )

• pro-B cell numbers are similar to that in homozygous Rad50^tm2Jpt mice

decreased double-negative T cell number ( J:103922 )

• double-negative T cell numbers are similar to that in homozygous Rad50^tm2Jpt mice

anemia ( J:103922 )

• 36 of 41 develop anemia

decreased macrophage cell number ( J:103922 )

• macrophage numbers are similar to that in homozygous Rad50^tm2Jpt mice

immune system

abnormal pro-B cell morphology ( J:103922 )

• pro-B cell numbers are similar to that in homozygous Rad50^tm2Jpt mice

decreased double-negative T cell number ( J:103922 )

• double-negative T cell numbers are similar to that in homozygous Rad50^tm2Jpt mice

decreased macrophage cell number ( J:103922 )

• macrophage numbers are similar to that in homozygous Rad50^tm2Jpt mice

Allelic Composition	Chek2^tm1Mak/Chek2^tm1Mak Rad50^tm2Jpt/Rad50^tm2Jpt
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:103922 )

• 13 of 65 die by 5 months of age, however survival time is increased compared to homozygous Rad50^tm2Jpt mice, as 52 mutants survive past 5 months of age and none develop anemia

neoplasm

increased lymphoma incidence ( J:103922 )

• 10 of 65 mice develop lymphoma

hematopoietic system

hematopoietic system phenotype ( J:103922 )

N	• exhibit hematopoietic rescue of the abnormalities seen in homozygous Rad50^tm2Jpt mice, with numbers of double-negative T cells, pro-B cells, and macrophages within 2-fold levels of wild-type levels

Allelic Composition	Cep63^{Gt(EUCE0251h11)Hmgu}/Cep63^{Gt(EUCE0251h11)Hmgu} Chek2^tm1Mak/Chek2^tm1Mak
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cep63^{Gt(EUCE0251h11)Hmgu} mutation (0 available); any Cep63 mutation (45 available)
Chek2^tm1Mak mutation (1 available); any Chek2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

thin cerebral cortex ( J:224364 )

• significant reduction in cortical thickness, as determined in motor and visual cortex sections at P60, similar to that in single Cep63^{Gt(EUCE0251h11)Hmgu} homozygotes

Allelic Composition	Chek2^tm1Mak/Chek2^tm1Mak Swsap1^em1Mjn/Swsap1^em1Mjn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek2^tm1Mak mutation (1 available); any Chek2 mutation (53 available)
Swsap1^em1Mjn mutation (0 available); any Swsap1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:268570 )

N	• mice exhibit normal ovary weight and follicle development

decreased oocyte number ( J:268570 )

• marginally

oligozoospermia ( J:268570 )

abnormal chromosomal synapsis ( J:268570 )

• with reduced MLH1 focus numbers

decreased primordial ovarian follicle number ( J:268570 )

abnormal seminiferous tubule morphology ( J:268570 )

• improved cellularity compared with Zswim7^em1Mjn homozygotes

decreased testis weight ( J:268570 )

impaired embryo implantation ( J:268570 )

• marginally

reduced female fertility ( J:268570 )

• reduced litter sizes

decreased litter size ( J:268570 )

• females produce reduced litters

male infertility ( J:268570 )

cellular

decreased oocyte number ( J:268570 )

• marginally

oligozoospermia ( J:268570 )

abnormal chromosomal synapsis ( J:268570 )

• with reduced MLH1 focus numbers

endocrine/exocrine glands

decreased primordial ovarian follicle number ( J:268570 )

abnormal seminiferous tubule morphology ( J:268570 )

• improved cellularity compared with Zswim7^em1Mjn homozygotes

decreased testis weight ( J:268570 )

Allelic Composition	Chek2^tm1Mak/Chek2^tm1Mak Zswim7^em1Mjn/Zswim7^em1Mjn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek2^tm1Mak mutation (1 available); any Chek2 mutation (53 available)
Zswim7^em1Mjn mutation (0 available); any Zswim7 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:268570 )

N	• mice exhibit normal ovary weight and follicle development

oligozoospermia ( J:268570 )

decreased primordial ovarian follicle number ( J:268570 )

abnormal seminiferous tubule morphology ( J:268570 )

• improved cellularity compared with Zswim7^em1Mjn homozygotes

decreased testis weight ( J:268570 )

reduced female fertility ( J:268570 )

• reduced litter sizes

decreased litter size ( J:268570 )

• females produce reduced litters

male infertility ( J:268570 )

cellular

oligozoospermia ( J:268570 )

endocrine/exocrine glands

decreased primordial ovarian follicle number ( J:268570 )

abnormal seminiferous tubule morphology ( J:268570 )

• improved cellularity compared with Zswim7^em1Mjn homozygotes

decreased testis weight ( J:268570 )

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