Phenotypes associated with this allele

• Allele Symbol: Gdf7^tm2Tmj
• Allele Name: targeted mutation 2, Thomas M Jessell
• Allele ID: MGI:2386906
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gdf7^tm2Tmj/Gdf7^tm3(cre)Tmj	involves: 129S1/Sv	MGI:3590215
cn2	Gdf7^tm2Tmj/Gdf7^+ Tg(Hsp70-1-cre)6Arge/0	involves: 129S1/Sv * C57BL/6J * CBA	MGI:3590213
cn3	Gdf7^tm2Tmj/Gdf7^+ Tmem163^Tg(ACTB-cre)2Mrt/0	involves: 129S1/Sv * FVB/N	MGI:3590217

Genotype
MGI:3590215

cn1

• Allelic Composition: Gdf7^tm2Tmj/Gdf7^tm3(cre)Tmj
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal choroid plexus morphology ( J:100435 )

• at E14.5 mesencephalic and diencephalic choroid plexus epithelium is reduced and increased apoptosis is seen in the residual diencephalic choroid plexus epithelium; however telencephalic choroid plexus epithelium is well preserved with only a slight reduction in the volume of the anterior domain

• at E16.5 papillary choroid plexus tissue is markedly reduced in the hindbrain and diencephalon

Genotype
MGI:3590213

cn2

• Allelic Composition: Gdf7^tm2Tmj/Gdf7⁺; Tg(Hsp70-1-cre)6Arge/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * CBA

nervous system

abnormal neural tube morphology ( J:60594 )

• at E11 at the spinal level the neural tube is smaller than normal

open neural tube ( J:60594 )

• at E11, the neural tube is open at the midbrain and hindbrain levels but closed at the spinal level

absent roof plate ( J:60594 )

decreased forebrain size ( J:60594 )

• forebrain structures are reduced in size

decreased midbrain size ( J:60594 )

• midbrain structures are reduced in size

abnormal dorsal interneuron morphology ( J:60594 )

• specific classes of dorsal sensory interneurons, including D1A, D1B, and D2 neurons, are absent and the domain of generation of D3 neurons is shifted dorsally; however numbers of motor neurons and ventral interneurons are normal or slightly increased

embryo

abnormal neural tube morphology ( J:60594 )

• at E11 at the spinal level the neural tube is smaller than normal

open neural tube ( J:60594 )

• at E11, the neural tube is open at the midbrain and hindbrain levels but closed at the spinal level

absent roof plate ( J:60594 )

Genotype
MGI:3590217

cn3

• Allelic Composition: Gdf7^tm2Tmj/Gdf7⁺; Tmem163^{Tg(ACTB-cre)2Mrt}/0
• Genetic Background: involves: 129S1/Sv * FVB/N

nervous system

open neural tube ( J:100435 )

• caudal regions of the neural tube remain open but in 96 of 98 embryos the forebrain is closed

absent choroid plexus ( J:100435 )

• at E12.5, E13.5, and E14.5, almost all choroid plexus epithelium is absent including that in the telencephalon

abnormal forebrain morphology ( J:100435 )

• gross forebrain abnormalities are seen at E10.5

• apoptosis is elevated in anterior levels of the dorsal midline region of the forebrain at E9.5 but at or below control levels by E10.0

embryo

open neural tube ( J:100435 )

• caudal regions of the neural tube remain open but in 96 of 98 embryos the forebrain is closed