Phenotypes associated with this allele

• Allele Symbol: Ogg1^tm1Tld
• Allele Name: targeted mutation 1, Tomas Lindahl
• Allele ID: MGI:2386943
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ogg1^tm1Tld/Ogg1^tm1Tld	involves: 129P2/OlaHsd	MGI:2386967
cx2	Mutyh^tm1Jhmi/Mutyh^tm1Jhmi Ogg1^tm1Tld/Ogg1^tm1Tld	involves: 129 * C57BL/6J	MGI:3043935
cx3	Msh2^tm1Mak/Msh2^tm1Mak Mutyh^tm1Jhmi/Mutyh^tm1Jhmi Ogg1^tm1Tld/Ogg1^tm1Tld	involves: 129 * C57BL/6J	MGI:3043936
cx4	Msh2^tm1Mak/Msh2^+ Mutyh^tm1Jhmi/Mutyh^tm1Jhmi Ogg1^tm1Tld/Ogg1^tm1Tld	involves: 129 * C57BL/6J	MGI:3043953

Genotype
MGI:2386967

hm1

• Allelic Composition: Ogg1^tm1Tld/Ogg1^tm1Tld
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:58517 )

• Remained viable and healthy until at least 18 months of age with no obvious phenotype

Genotype
MGI:3043935

cx2

• Allelic Composition: Mutyh^tm1Jhmi/Mutyh^tm1Jhmi; Ogg1^tm1Tld/Ogg1^tm1Tld
• Genetic Background: involves: 129 * C57BL/6J

mortality/aging

premature death ( J:89742 )

• the 50% survival age is 10.3 months

neoplasm

increased tumor incidence ( J:89742 )

• 65.7% of mice develop tumors, predominantly lymphoma (37.1%), ovarian tumors (34.8%), and lung adenomas (31.4%)

• 75% of lung tumors have a G to T mutation in codon 12 of Kras2

increased ovary tumor incidence ( J:89742 )

♀ • 34.8% of mutants develop ovarian tumors after 12 months of age

♀ • 4 of 5 ovarian tumors are bilateral

increased hemangioma incidence ( J:89742 )

• most ovarian tumors are hemangiomas which can result in lethal hemorrhaging

increased lymphoma incidence ( J:89742 )

• observe in 37.1% of mice, with extensive lymphoma burdens in most organs such as the lung, heart, liver, spleen, kidneys, and lymph nodes

increased lung tumor incidence ( J:89742 )

• 31.4% of mutants develop lung tumors after 12 months of age

• 78.6% of older mutants that live more than 12 months develop lung tumors

• lung tumors are solitary and white nodules with a 1-10 mm diameter

increased lung adenoma incidence ( J:89742 )

• most lung tumors are adenomas, seen in 31.4% of mutants

endocrine/exocrine glands

increased ovary tumor incidence ( J:89742 )

♀ • 34.8% of mutants develop ovarian tumors after 12 months of age

♀ • 4 of 5 ovarian tumors are bilateral

reproductive system

increased ovary tumor incidence ( J:89742 )

♀ • 34.8% of mutants develop ovarian tumors after 12 months of age

♀ • 4 of 5 ovarian tumors are bilateral

respiratory system

increased lung tumor incidence ( J:89742 )

• 31.4% of mutants develop lung tumors after 12 months of age

• 78.6% of older mutants that live more than 12 months develop lung tumors

• lung tumors are solitary and white nodules with a 1-10 mm diameter

increased lung adenoma incidence ( J:89742 )

• most lung tumors are adenomas, seen in 31.4% of mutants

Genotype
MGI:3043936

cx3

• Allelic Composition: Msh2^tm1Mak/Msh2^tm1Mak; Mutyh^tm1Jhmi/Mutyh^tm1Jhmi; Ogg1^tm1Tld/Ogg1^tm1Tld
• Genetic Background: involves: 129 * C57BL/6J

mortality/aging

premature death ( J:89742 )

• the 50% survival age is 4.3 months and all mutants die within 10.3 months

neoplasm

increased tumor incidence ( J:89742 )

• 86.7% of mice develop tumors, predominantly lymphoma (76.7%) with some incidence of lung adenoma (10%)

increased lung adenoma incidence ( J:89742 )

• observe in 10% of mice

increased lymphoma incidence ( J:89742 )

• observe in 76.7% of mice

respiratory system

increased lung adenoma incidence ( J:89742 )

• observe in 10% of mice

Genotype
MGI:3043953

cx4

• Allelic Composition: Msh2^tm1Mak/Msh2⁺; Mutyh^tm1Jhmi/Mutyh^tm1Jhmi; Ogg1^tm1Tld/Ogg1^tm1Tld
• Genetic Background: involves: 129 * C57BL/6J

mortality/aging

premature death ( J:89742 )

• the 50% survival age is around 10 months

neoplasm

increased tumor incidence ( J:89742 )

• 76.9% of mice develop tumors, including ovarian tumors (57.6%), lung adenomas (35.9%), lung adenocarcinoma (61.3%), lymphoma (26.9%)

increased ovary tumor incidence ( J:89742 )

♀ • in 57.6% of mice, with the earliest onset at 5 months of age

increased lung adenoma incidence ( J:89742 )

• observe in 35.9% of mice

increased lymphoma incidence ( J:89742 )

• observe in 26.9% of mice

increased lung adenocarcinoma incidence ( J:89742 )

• 61.3% of mutants develop lung adenocarcinomas after 10.6 months of age

respiratory system

increased lung adenoma incidence ( J:89742 )

• observe in 35.9% of mice

increased lung adenocarcinoma incidence ( J:89742 )

• 61.3% of mutants develop lung adenocarcinomas after 10.6 months of age

endocrine/exocrine glands

increased ovary tumor incidence ( J:89742 )

♀ • in 57.6% of mice, with the earliest onset at 5 months of age

reproductive system

increased ovary tumor incidence ( J:89742 )

♀ • in 57.6% of mice, with the earliest onset at 5 months of age