Phenotypes associated with this allele

• Allele Symbol: Nova1^tm1Rbd
• Allele Name: targeted mutation 1, Robert B Darnell
• Allele ID: MGI:2386947
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nova1^tm1Rbd/Nova1^tm1Rbd	Not Specified	MGI:3844860

Genotype
MGI:3844860

hm1

• Allelic Composition: Nova1^tm1Rbd/Nova1^tm1Rbd
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:60771 )

• mice die 7 to 10 days after birth

behavior/neurological

tremors ( J:60771 )

• action-induced

abnormal motor coordination/balance ( J:60771 )

• after birth mice develop progressive motor dysfunction and are unable to walk without falling

weakness ( J:60771 )

• mice exhibit motor weakness unlike wild-type mice

nervous system

increased neuron apoptosis ( J:60771 )

• mice exhibit an increase in apoptotic death in the hindbrain and ventral spinal cord neurons compared to in wild-type mice

abnormal spinal cord morphology ( J:60771 )

• mice exhibit a 4-fold increase in the number of pyknotic cells compared to in wild-type mice in the ventral region of the spinal cord, in specific brainstem nuclei, most notably CN XII and the deep cerebellar nuclei

growth/size/body

decreased fetal size ( J:60771 )

cellular

increased neuron apoptosis ( J:60771 )

• mice exhibit an increase in apoptotic death in the hindbrain and ventral spinal cord neurons compared to in wild-type mice