Analysis Tools
behavior/neurological
| N |
• no significant difference between mutant and control mice is detectable for anxiety responses using the open-field, light-dark exploration, and elevated plus maze tests
|
|
• amplitude of the overall startle response to a 120-dB sound stimulus is significantly lower in mutant male mice than in female mutant mice or in controls
• similar levels of prepulse inhibition are seen in both mutant and control mice, indicating that hearing is normal
|
|
• the startle threshold, defined as the stimulus level which produces a significantly higher response than the baseline response measured at 70 dB, for mutant mice is 78 dB; for control mice it is 90 dB; thus, mutant mice are more sensitive at low sound levels to controls
|
hearing/vestibular/ear
| N |
• ABR testing indicates that there is no significant difference between wild-type and mutant mice in their multiwave response and interpeak latency at the range of 70- to 90-dB sound stimuli
|
nervous system
| N |
• stress-induced autonomic control responses in mutant mice is similar to controls; heart rate in free-running animals at baseline, during physical restraint and during recovery is similar, and stress-induced endocrine responses, as indicated by the plasma corticosterone, epinephrine,
and norepinephrine levels are not different in mutant and control animals
|
