Phenotypes associated with this allele

• Allele Symbol: Plxna3^tm1Matl
• Allele Name: targeted mutation 1, Marc Tessier-Lavigne
• Allele ID: MGI:2386961
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plxna3^tm1Matl/Plxna3^tm1Matl	either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)	MGI:3041539
hm2	Plxna3^tm1Matl/Plxna3^tm1Matl	involves: 129S1/Sv	MGI:5007635
cx3	Plxna3^tm1Matl/Y Plxna4^tm1Matl/Plxna4^tm1Matl	either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)	MGI:3579482
cx4	Plxna3^tm1Matl/Plxna3^tm1Matl Plxna4^tm1Matl/Plxna4^tm1Matl	either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)	MGI:3590677
cx5	Plxna1^tm1Tmj/Plxna1^tm1Tmj Plxna3^tm1Matl/Plxna3^tm1Matl	involves: 129S/SvEv * 129S1/Sv	MGI:5284893
ot6	Plxna3^tm1Matl/Y	either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)	MGI:3041540

Genotype
MGI:3041539

hm1

• Allelic Composition: Plxna3^tm1Matl/Plxna3^tm1Matl
• Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon guidance ( J:72426 )

♀ • repulsive effect of Sema3A and Sema3F on axon growth from sympathetic nerves, dorsal root ganglia and areas of the hippocampus is eliminated

abnormal axon pruning ( J:83314 )

♀ • axon pruning directed by Sema3A does not occur

abnormal hippocampus morphology ( J:72426 )

♀

abnormal Ammon gyrus morphology ( J:72426 )

♀ • afferent pathways from CA3 to the contralateral hippocampus is underdeveloped

♀ • the few axons entering the contralateral hippocampus terminate inappropriately

♀ • most axons are misrouted ipsilaterally

abnormal hippocampal mossy fiber morphology ( J:72426 , J:83314 )

♀ • infrapyramidal bundle fails to rejoin the main mossy fiber pathway (J:72426)

♀ • infrapyramidal bundle fails to shorten as it does in wild-type mice (J:83314)

abnormal trigeminal nerve morphology ( J:72426 )

♀ • ophthalmic branch defasciculated at E10.5 through E11.5

♀ • cranial nerve projections normal at E10.5

cellular

abnormal axon guidance ( J:72426 )

♀ • repulsive effect of Sema3A and Sema3F on axon growth from sympathetic nerves, dorsal root ganglia and areas of the hippocampus is eliminated

abnormal axon pruning ( J:83314 )

♀ • axon pruning directed by Sema3A does not occur

Genotype
MGI:5007635

hm2

• Allelic Composition: Plxna3^tm1Matl/Plxna3^tm1Matl
• Genetic Background: involves: 129S1/Sv

vision/eye

vision/eye phenotype ( J:172268 )

♀N • mice exhibit normal retinal stratification

Genotype
MGI:3579482

cx3

• Allelic Composition: Plxna3^tm1Matl/Y; Plxna4^tm1Matl/Plxna4^tm1Matl
• Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

nervous system

abnormal axon guidance ( J:98440 )

♂ • repulsive effect of Sema3A on axon growth from sensory neurons of the dorsal root ganglia and of superior cervical ganglion neurons was eliminated

abnormal sensory neuron innervation pattern ( J:98440 )

♂ • starting at E11.5, had severely disrupted peripheral sensory projections, with many axons crossing the dorsal midline to the other side of the body at E12.5

♂ • peripheral sensory projections exhibited extensive outgrowth and branching as if there were no boundaries for the axons

abnormal trigeminal nerve morphology ( J:98440 )

♂ • severely disorganized and derasciculated ophthalmic, maxillary and mandibular projections at E11.5

♂ • more fibers of the ophthalmic branch misprojected in different directions, and some even started to invade the eye region at E11.5 and the ophthalmic axon fibers covered the entire face, including the eyes and the fibers were thinner and heavily branched at E12.5 compared to wildtype

abnormal trochlear nerve morphology ( J:98440 )

♂ • severely defasciculated even though individual axons could still be seen leaving the midbrain-hindbrain junction

cellular

abnormal axon guidance ( J:98440 )

♂ • repulsive effect of Sema3A on axon growth from sensory neurons of the dorsal root ganglia and of superior cervical ganglion neurons was eliminated

Genotype
MGI:3590677

cx4

• Allelic Composition: Plxna3^tm1Matl/Plxna3^tm1Matl; Plxna4^tm1Matl/Plxna4^tm1Matl
• Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

nervous system

abnormal axon guidance ( J:98440 )

♀ • repulsive effect of Sema3A on axon growth from sensory neurons of the dorsal root ganglia and of superior cervical ganglion neurons was eliminated

abnormal sensory neuron innervation pattern ( J:98440 )

♀ • starting at E11.5, had severely disrupted peripheral sensory projections, with many axons crossing the dorsal midline to the other side of the body at E12.5

♀ • peripheral sensory projections exhibited extensive outgrowth and branching as if there were no boundaries for the axons

abnormal trigeminal nerve morphology ( J:98440 )

♀ • severely disorganized and derasciculated ophthalmic, maxillary and mandibular projections at E11.5

♀ • more fibers of the ophthalmic branch misprojected in different directions, and some even started to invade the eye region at E11.5 and the ophthalmic axon fibers covered the entire face, including the eyes and the fibers were thinner and heavily branched at E12.5 compared to wildtype

abnormal trochlear nerve morphology ( J:98440 )

♀ • severely defasciculated even though individual axons could still be seen leaving the midbrain-hindbrain junction

cellular

abnormal axon guidance ( J:98440 )

♀ • repulsive effect of Sema3A on axon growth from sensory neurons of the dorsal root ganglia and of superior cervical ganglion neurons was eliminated

Genotype
MGI:5284893

cx5

• Allelic Composition: Plxna1^tm1Tmj/Plxna1^tm1Tmj; Plxna3^tm1Matl/Plxna3^tm1Matl
• Genetic Background: involves: 129S/SvEv * 129S1/Sv

vision/eye

abnormal amacrine cell morphology ( J:174679 )

♀ • multiple amacrine cell subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer

abnormal retina bipolar cell morphology ( J:174679 )

♀ • multiple retinal bipolar cell subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer

abnormal retina ganglion cell morphology ( J:174679 )

♀ • multiple retinal ganglion subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer

abnormal retina inner nuclear layer morphology ( J:174679 )

♀ • multiple retinal ganglion, amacrine and bipolar cell subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer

abnormal retina inner plexiform layer morphology ( J:174679 )

♀ • exhibit severe, fully penetrant and expressive, defects in inner plexiform layer neurite targeting

abnormal retina outer plexiform layer morphology ( J:174679 )

♀ • multiple retinal ganglion, amacrine and bipolar cell subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer

nervous system

abnormal neurite morphology ( J:174679 )

♀ • exhibit severe, fully penetrant and expressive, defects in inner plexiform layer neurite targeting

♀ • multiple retinal ganglion, amacrine and bipolar cell subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer

abnormal amacrine cell morphology ( J:174679 )

♀ • multiple amacrine cell subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer

abnormal retina bipolar cell morphology ( J:174679 )

♀ • multiple retinal bipolar cell subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer

abnormal retina ganglion cell morphology ( J:174679 )

♀ • multiple retinal ganglion subtypes exhibit aberrant neurite extension into the inner nuclear layer and outer plexiform layer

Genotype
MGI:3041540

ot6

• Allelic Composition: Plxna3^tm1Matl/Y
• Genetic Background: either: (involves: 129S1/Sv * C57BL/6) or (involves: 129S1/Sv * CD-1)

nervous system

abnormal axon guidance ( J:72426 )

♂ • repulsive effect of Sema3A and Sema3F on axon growth from sympathetic nerves, dorsal root ganglia and areas of the hippocampus is eliminated

abnormal axon pruning ( J:83314 )

♂ • axon pruning directed by Sema3A does not occur

abnormal hippocampus morphology ( J:72426 )

♂

abnormal Ammon gyrus morphology ( J:72426 )

♂ • afferent pathways from CA3 to the contralateral hippocampus is underdeveloped

♂ • the few axons entering the contralateral hippocampus terminate inappropriately

♂ • most axons are misrouted ipsilaterally

abnormal hippocampal mossy fiber morphology ( J:72426 , J:83314 )

♂ • infrapyramidal bundle fails to rejoin the main mossy fiber pathway (J:72426)

♂ • infrapyramidal bundle fails to shorten as it does in wild-type mice (J:83314)

abnormal trigeminal nerve morphology ( J:72426 )

♂ • ophthalmic branch defasciculated at E10.5 through E11.5

♂ • cranial nerve projections normal at E10.5

cellular

abnormal axon guidance ( J:72426 )

♂ • repulsive effect of Sema3A and Sema3F on axon growth from sympathetic nerves, dorsal root ganglia and areas of the hippocampus is eliminated

abnormal axon pruning ( J:83314 )

♂ • axon pruning directed by Sema3A does not occur