About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(LPV-TAg1135)11Tvd
transgene insertion 11, Terry Van Dyke
MGI:2386975
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Rag1tm1Mom/Rag1+
Tg(LPV-TAg1135)11Tvd/0 		involves: 129/Sv * C57BL/6 * DBA/2 MGI:2665123
cx2
 		Rag1tm1Mom/Rag1tm1Mom
Tg(LPV-TAg1135)11Tvd/0 		involves: 129/Sv * C57BL/6 * DBA/2 MGI:2665126
cx3
 		Rag2tm1Fwa/Rag2tm1Fwa
Tg(LPV-TAg1135)11Tvd/0 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:2665128
cx4
 		Rag2tm1Fwa/Rag2+
Tg(LPV-TAg1135)11Tvd/0 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:2665131
cx5
 		Rag1tm1Mom/Rag1tm1Mom
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0 		involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:2665134
cx6
 		Rag1tm1Mom/Rag1+
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0 		involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:2665135
cx7
 		Prkdcscid/Prkdcscid
Tg(LPV-TAg1135)11Tvd/0 		involves: C57BL/6J * DBA/2J MGI:2665136
cx8
 		Prkdcscid/Prkdc+
Tg(LPV-TAg1135)11Tvd/0 		involves: C57BL/6J * DBA/2J MGI:2665137


Genotype
MGI:2665123
cx1
Allelic
Composition		 Rag1tm1Mom/Rag1+
Tg(LPV-TAg1135)11Tvd/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(LPV-TAg1135)11Tvd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 165 days

neoplasm
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma

immune system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma

hematopoietic system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma




Genotype
MGI:2665126
cx2
Allelic
Composition		 Rag1tm1Mom/Rag1tm1Mom
Tg(LPV-TAg1135)11Tvd/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(LPV-TAg1135)11Tvd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 238 days

neoplasm
increased T cell derived lymphoma incidence ( J:47667 )
• 85% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 44% longer than controls

hematopoietic system
increased T cell derived lymphoma incidence ( J:47667 )
• 85% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 44% longer than controls
abnormal T cell receptor V(D)J recombination ( J:47667 )
• inactive V(D)J recombination

immune system
increased T cell derived lymphoma incidence ( J:47667 )
• 85% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 44% longer than controls
abnormal T cell receptor V(D)J recombination ( J:47667 )
• inactive V(D)J recombination

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:47667 )
• 85% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 44% longer than controls




Genotype
MGI:2665128
cx3
Allelic
Composition		 Rag2tm1Fwa/Rag2tm1Fwa
Tg(LPV-TAg1135)11Tvd/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (121 available)
Tg(LPV-TAg1135)11Tvd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 167 days

neoplasm
increased T cell derived lymphoma incidence ( J:47667 )
• 83% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 14% longer than controls

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:47667 )
• 83% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 14% longer than controls

immune system
increased T cell derived lymphoma incidence ( J:47667 )
• 83% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 14% longer than controls

hematopoietic system
increased T cell derived lymphoma incidence ( J:47667 )
• 83% incidence of thymoma
• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 14% longer than controls




Genotype
MGI:2665131
cx4
Allelic
Composition		 Rag2tm1Fwa/Rag2+
Tg(LPV-TAg1135)11Tvd/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (121 available)
Tg(LPV-TAg1135)11Tvd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 146 days

neoplasm
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma

immune system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma

hematopoietic system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma




Genotype
MGI:2665134
cx5
Allelic
Composition		 Rag1tm1Mom/Rag1tm1Mom
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(LPV-TAg1135)11Tvd mutation (1 available)
Tg(TcrLCMV)327Sdz mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 101 days

neoplasm
increased T cell derived lymphoma incidence ( J:47667 )
• 100% of mutants develop thymic lymphoma within the same accelerated time frame as mutants heterozygous for Rag1 and hemizygous for the two transgenes

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:47667 )
• 100% of mutants develop thymic lymphoma within the same accelerated time frame as mutants heterozygous for Rag1 and hemizygous for the two transgenes

hematopoietic system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% of mutants develop thymic lymphoma within the same accelerated time frame as mutants heterozygous for Rag1 and hemizygous for the two transgenes

immune system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% of mutants develop thymic lymphoma within the same accelerated time frame as mutants heterozygous for Rag1 and hemizygous for the two transgenes




Genotype
MGI:2665135
cx6
Allelic
Composition		 Rag1tm1Mom/Rag1+
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(LPV-TAg1135)11Tvd mutation (1 available)
Tg(TcrLCMV)327Sdz mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 110 days

neoplasm
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma
• tumorigenesis is accelerated compared to mice hemizygous for Tg(LPV-TAg1135)11Tvd and heterozygous for Rag1

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma
• tumorigenesis is accelerated compared to mice hemizygous for Tg(LPV-TAg1135)11Tvd and heterozygous for Rag1

hematopoietic system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma
• tumorigenesis is accelerated compared to mice hemizygous for Tg(LPV-TAg1135)11Tvd and heterozygous for Rag1

immune system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% incidence of thymoma
• tumorigenesis is accelerated compared to mice hemizygous for Tg(LPV-TAg1135)11Tvd and heterozygous for Rag1




Genotype
MGI:2665136
cx7
Allelic
Composition		 Prkdcscid/Prkdcscid
Tg(LPV-TAg1135)11Tvd/0
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdcscid mutation (179 available); any Prkdc mutation (418 available)
Tg(LPV-TAg1135)11Tvd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 210 days

neoplasm
increased thymoma incidence ( J:47667 )
• 62% incidence of thymoma, however tumor development is not accelerated compared to heterozygous Prkdc and hemizygous Tg(LPV-TAg1135)11Tvd mice, and is actually slightly delayed




Genotype
MGI:2665137
cx8
Allelic
Composition		 Prkdcscid/Prkdc+
Tg(LPV-TAg1135)11Tvd/0
Genetic
Background		 involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdcscid mutation (179 available); any Prkdc mutation (418 available)
Tg(LPV-TAg1135)11Tvd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 183 days

neoplasm
increased thymoma incidence ( J:47667 )
• 93% incidence of thymoma




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory