Analysis Tools
immune system
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• the percentage of CD8+ T cells found in the spleen does not increase after MCMV infection as it does in wild-type mice
• LCMV infection only leads to a third the increase of CD8+ T cells in the spleen that occurs in wild-type mice
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• CTLs from mutant mice primed with ovalbumin lyse fewer cells presenting the Ova immunodominant epitope than do controls
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• MHC-I complexes on the surface of lymphocytes have less thermodynamic stability
• there is a 70% reduction in presentation of hydrophobic peptides by interferon treated antigen presenting cells
• lymphoblasts fail to present the class I Kb-restricted Ova257-264 immunodominant epitope
• the subdominant ovalbumin epitope Ova55-72 is also not presented
• presentation of an immunodominant epitopes from influenza virus nuclear protein and from male HY antigen is also severely reduced
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hematopoietic system
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• the percentage of CD8+ T cells found in the spleen does not increase after MCMV infection as it does in wild-type mice
• LCMV infection only leads to a third the increase of CD8+ T cells in the spleen that occurs in wild-type mice
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• CTLs from mutant mice primed with ovalbumin lyse fewer cells presenting the Ova immunodominant epitope than do controls
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