Phenotypes associated with this allele

• Allele Symbol: Ngfr^tm1Gdc
• Allele Name: targeted mutation 1, Georg Dechant
• Allele ID: MGI:2386981
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ngfr^tm1Gdc/Ngfr^tm1Gdc	involves: 129X1/SvJ * C57BL/6	MGI:2450868

Genotype
MGI:2450868

hm1

• Allelic Composition: Ngfr^tm1Gdc/Ngfr^tm1Gdc
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:71955 )

• 40% fewer homozygous progeny than expected by mendelian ratios

behavior/neurological

ataxia ( J:71955 )

• impaired motility due to hind limb ataxia

abnormal posture ( J:71955 )

• abnormal response when held by tail, upward stretching of posterior limbs

abnormal gait ( J:71955 )

• abnormal waddling, "mud-walking"

cardiovascular system

abnormal blood vessel morphology ( J:71955 )

• dorsal aorta and other large blood vessels were dilated at E11.5

• thin vessel walls

dilated dorsal aorta ( J:71955 )

hemorrhage ( J:71955 )

• blood vessel ruptures and concomitant blood cell leakage observed

growth/size/body

decreased body size ( J:71955 )

nervous system

decreased Schwann cell number ( J:71955 )

abnormal L5 dorsal root ganglion morphology ( J:71955 )

• 54% decrease in sensory neurons in L5 DRG relative to wild-type 3-4 days after birth

abnormal sciatic nerve morphology ( J:71955 )

• ~53% decrease in cross-sectional area of sciatic nerve relative to wild-type