Analysis Tools
renal/urinary system
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• exhibit fewer and smaller secretory granules in the juxtaglomerular cells
• otherwise, kidneys are histologically normal
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cardiovascular system
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• exhibit a small but significant reduction in blood pressure, with females having a larger decrease in blood pressure than males
• however, do not develop severe hypotension as acute administration of losartan decreases blood pressure further
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homeostasis/metabolism
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• circulating renin is reduced, with males having 22% of wild-type levels and females 7% of wild-type levels
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