All Phenotypes Il6st<tm2Thir> MGI Mouse

neonatal lethality, complete penetrance ( J:59922 )

• pups die within one day of birth

• in lethally irradiated wild-type mice receiving mutant fetal liver cells, there is a 45% reduction in the number of B-1a B cells found in the peritoneum

decreased IgG1 level ( J:59922 )

• the primary and secondary antigen-specific IgG1 response to immunization with T cell dependent antigen is reduced in lethally irradiated mice receiving mutant fetal liver cells

decreased IgG2a level ( J:59922 )

• in lethally irradiated wild-type mice receiving mutant fetal liver cells, IgG2a levels are significantly lower than controls

• the primary antigen-specific IgG2a response to immunization with T cell dependent antigen is also reduced in these chimeric mice

decreased IgG2b level ( J:59922 )

• in lethally irradiated wild-type mice receiving mutant fetal liver cells, IgG2b levels are significantly lower than controls

• the primary and secondary antigen-specific IgG2b response to immunization with T cell dependent antigen is also reduced in these chimeric mice

increased IgM level ( J:59922 )

• the secondary antigen-specific IgM response to immunization with T cell dependent antigen is increased in lethally irradiated mice receiving mutant fetal liver cells

abnormal dendritic cell antigen presentation ( J:113335 )

• bone marrow derived dendritic cells treated with IL-6 have a greater reduction in MHC-II surface expression than in controls

• dendritic cells isolated from lymph nodes have a 40% reduction in surface expression of MHC-II

decreased interferon-gamma secretion ( J:59922 )

• in lethally irradiated mice receiving mutant fetal liver cells, IFN-gamma secretion is 0.6-fold of that in wild-type mice

abnormal bone marrow cell morphology/development ( J:59922 )

• there is a slight but significant reduction in CFU-M isolated from the bone marrow when macrophage-colony stimulating factor is used as a stimulus

decreased B-1a cell number ( J:59922 )