Analysis Tools
mortality/aging
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• pups die within one day of birth
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• some embryos die before E14.5
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immune system
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• in lethally irradiated wild-type mice receiving mutant fetal liver cells, IgGA levels are significantly lower than controls
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• in lethally irradiated wild-type mice receiving mutant fetal liver cells, IgG2a levels are significantly lower than controls
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• in lethally irradiated wild-type mice receiving mutant fetal liver cells, IgG2b levels are significantly lower than controls
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nervous system
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• glial fibrillary acidic protein(GFAP)-positive astrocytes are not present in the marginal zone of cervical spinal cord of E18.5 embryos
• GFAP-positive acstrocytes do no develop from neural explants of E14.5 cerebral cortices in the presence of IL-6, ciliary neurotrophic factor, or oncostatin M
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hematopoietic system
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• there is a two-thirds reduction in CFU-M isolated from the bone marrow when macrophage-colony stimulating factor is used as a stimulus
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• in lethally irradiated wild-type mice receiving mutant fetal liver cells, IgGA levels are significantly lower than controls
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• in lethally irradiated wild-type mice receiving mutant fetal liver cells, IgG2a levels are significantly lower than controls
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• in lethally irradiated wild-type mice receiving mutant fetal liver cells, IgG2b levels are significantly lower than controls
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