About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd79btm1Mnz
targeted mutation 1, Michel C Nussenzweig
MGI:2387024
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd79btm1Mnz/Cd79btm1Mnz involves: 129S1/Sv MGI:4453799
cx2
 		Cd79btm1Mnz/Cd79btm1Mnz
Tg(Rag2-Igb)1Mnz/0 		involves: 129S1/Sv MGI:2653667
cx3
 		Cd79atm2Pld/Cd79atm2Pld
Cd79btm1Mnz/Cd79btm1Mnz 		involves: 129S1/Sv * BALB/c MGI:2687387
cx4
 		Cd79btm1Mnz/Cd79btm1Mnz
Tg(IghelMD4)4Ccg/0
Tg(Rag2-Igb)1Mnz/0 		involves: 129S1/Sv * C57BL/6 MGI:4453800
cx5
 		Cd79btm1Mnz/Cd79btm1Mnz
Tg(BCL2)22Wehi/0
Tg(IghelMD4)4Ccg/0
Tg(Rag2-Igb)1Mnz/0 		involves: 129S1/Sv * C57BL/6 * C57BL/6JWehi * SJL/JWehi MGI:4453802
cx6
 		Cd79btm1Mnz/Cd79btm1Mnz
Tg(BCL2)22Wehi/0
Tg(Rag2-Igb)1Mnz/0 		involves: 129S1/Sv * C57BL/6JWehi * SJL/JWehi MGI:4453801


Genotype
MGI:4453799
hm1
Allelic
Composition		 Cd79btm1Mnz/Cd79btm1Mnz
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79btm1Mnz mutation (0 available); any Cd79b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal pro-B cell morphology ( J:78601 )
• pro-B cells exhibit increased apoptosis
abnormal pro-B cell differentiation ( J:78601 )
• pro-B cell development is arrested
arrested B cell differentiation ( J:78601 )
• pro-B cell development is arrested

immune system
abnormal pro-B cell morphology ( J:78601 )
• pro-B cells exhibit increased apoptosis
abnormal pro-B cell differentiation ( J:78601 )
• pro-B cell development is arrested
arrested B cell differentiation ( J:78601 )
• pro-B cell development is arrested




Genotype
MGI:2653667
cx2
Allelic
Composition		 Cd79btm1Mnz/Cd79btm1Mnz
Tg(Rag2-Igb)1Mnz/0
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79btm1Mnz mutation (0 available); any Cd79b mutation (36 available)
Tg(Rag2-Igb)1Mnz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:78601 )
• B cells fail to proceed past the pre-B cell stage and do not differentiate into IgM+ immature B cells
abnormal pre-B cell morphology ( J:78601 )
• pre-B cells exhibit increased apoptosis

immune system
arrested B cell differentiation ( J:78601 )
• B cells fail to proceed past the pre-B cell stage and do not differentiate into IgM+ immature B cells
abnormal pre-B cell morphology ( J:78601 )
• pre-B cells exhibit increased apoptosis




Genotype
MGI:2687387
cx3
Allelic
Composition		 Cd79atm2Pld/Cd79atm2Pld
Cd79btm1Mnz/Cd79btm1Mnz
Genetic
Background		 involves: 129S1/Sv * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm2Pld mutation (0 available); any Cd79a mutation (24 available)
Cd79btm1Mnz mutation (0 available); any Cd79b mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
absent pre-B cells ( J:87492 )
• VH to DJH rearrangement unaffected

immune system
absent pre-B cells ( J:87492 )
• VH to DJH rearrangement unaffected




Genotype
MGI:4453800
cx4
Allelic
Composition		 Cd79btm1Mnz/Cd79btm1Mnz
Tg(IghelMD4)4Ccg/0
Tg(Rag2-Igb)1Mnz/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79btm1Mnz mutation (0 available); any Cd79b mutation (36 available)
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(Rag2-Igb)1Mnz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal immature B cell morphology ( J:78601 )
• increase in apoptosis of immature B cells
arrested B cell differentiation ( J:78601 )
• B cells fail to develop beyond the IgMlow immature B cell stage and no mature recirculating CD25-IgMhigh B cells are seen

immune system
abnormal immature B cell morphology ( J:78601 )
• increase in apoptosis of immature B cells
arrested B cell differentiation ( J:78601 )
• B cells fail to develop beyond the IgMlow immature B cell stage and no mature recirculating CD25-IgMhigh B cells are seen




Genotype
MGI:4453802
cx5
Allelic
Composition		 Cd79btm1Mnz/Cd79btm1Mnz
Tg(BCL2)22Wehi/0
Tg(IghelMD4)4Ccg/0
Tg(Rag2-Igb)1Mnz/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79btm1Mnz mutation (0 available); any Cd79b mutation (36 available)
Tg(BCL2)22Wehi mutation (2 available)
Tg(IghelMD4)4Ccg mutation (3 available)
Tg(Rag2-Igb)1Mnz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:78601 )
• expression of Tg(BCL2)22Wehi rescues immature B cell apoptosis but immature B cell differentiation beyond the IgMlow immature B cell stage is still impaired and no mature recirculating CD25-IgMhigh B cells are seen

immune system
arrested B cell differentiation ( J:78601 )
• expression of Tg(BCL2)22Wehi rescues immature B cell apoptosis but immature B cell differentiation beyond the IgMlow immature B cell stage is still impaired and no mature recirculating CD25-IgMhigh B cells are seen




Genotype
MGI:4453801
cx6
Allelic
Composition		 Cd79btm1Mnz/Cd79btm1Mnz
Tg(BCL2)22Wehi/0
Tg(Rag2-Igb)1Mnz/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79btm1Mnz mutation (0 available); any Cd79b mutation (36 available)
Tg(BCL2)22Wehi mutation (2 available)
Tg(Rag2-Igb)1Mnz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:78601 )
• expression of Tg(BCL2)22Wehi rescues pre-B cells from cell death but pre-B cell differentiation into IgM- immature B cells is still impaired

immune system
arrested B cell differentiation ( J:78601 )
• expression of Tg(BCL2)22Wehi rescues pre-B cells from cell death but pre-B cell differentiation into IgM- immature B cells is still impaired




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory