Phenotypes associated with this allele

• Allele Symbol: Cyp7b1^tm1Rus
• Allele Name: targeted mutation 1, David W Russell
• Allele ID: MGI:2387030
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp7b1^tm1Rus/Cyp7b1^tm1Rus	involves: 129S/SvEv * C57BL/6J	MGI:3047485

Genotype
MGI:3047485

hm1

• Allelic Composition: Cyp7b1^tm1Rus/Cyp7b1^tm1Rus
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:62587 )

N • both male and female homozygotes display normal bile acid metabolism

N • also, both male and female homozygotes exhibit normal plasma cholesterol and triglyceride levels relative to wild-type

N • the cholesterol contents of major tissues remain unaffected relative to wild-type

abnormal cholesterol homeostasis ( J:62589 , J:62587 )

• in contrast to levels of 25- and 27-hydroxycholesterol, which are significantly elevated, levels of another major oxysterol, 24-hydroxycholesterol, remain unaffected (J:62589)

• plasma and tissue levels of 25- and 27-hydroxycholesterol are significantly increased (J:62587)

• in vivo sterol biosynthetic rates remain relatively normal in most tissues with the exception of the male kidney, which shows a ~40% reduction in de novo synthesis relative to wild-type (J:62587)

immune system

decreased IgA level ( J:170807 )

• in the sera, lungs, and intestinal mucosa

hematopoietic system

decreased IgA level ( J:170807 )

• in the sera, lungs, and intestinal mucosa