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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cebpatm2Nerl
targeted mutation 2, Claus Nerlov
MGI:2387093
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cebpatm2Nerl/Cebpatm2Nerl involves: 129P2/OlaHsd * C57BL/6 MGI:3809498
cn2
 		Cebpatm1Gonz/Cebpatm2Nerl
Cebpbtm1Nerl/Cebpbtm1Nerl
Tg(KRT14-cre)1Cgn/0 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2 MGI:4366855


Genotype
MGI:3809498
hm1
Allelic
Composition		 Cebpatm2Nerl/Cebpatm2Nerl
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpatm2Nerl mutation (0 available); any Cebpa mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:72330 )
• fewer than expected mice are alive at 8 weeks of age

adipose tissue
decreased white adipose tissue amount ( J:72330 )
• mice have little to no white adipose tissue unlike in wild-type mice
abnormal gonadal fat pad morphology ( J:72330 )
• the gonadal fat pad is hypotrophic and adipocytes within it are smaller than normal

hematopoietic system
abnormal granulocyte morphology ( J:72330 )
• granulocytes are large and dysplastic
decreased granulocyte number ( J:72330 )
• in the bone marrow and peripheral blood

immune system
immune system phenotype ( J:72330 )
N
• despite the defects in granulocytes, other hematopoietic lineages are normal
abnormal granulocyte morphology ( J:72330 )
• granulocytes are large and dysplastic
decreased granulocyte number ( J:72330 )
• in the bone marrow and peripheral blood




Genotype
MGI:4366855
cn2
Allelic
Composition		 Cebpatm1Gonz/Cebpatm2Nerl
Cebpbtm1Nerl/Cebpbtm1Nerl
Tg(KRT14-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpatm1Gonz mutation (1 available); any Cebpa mutation (19 available)
Cebpatm2Nerl mutation (0 available); any Cebpa mutation (19 available)
Cebpbtm1Nerl mutation (0 available); any Cebpb mutation (26 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument

cellular




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory