Analysis Tools|
Allele Symbol Allele Name Allele ID |
Skiltm1Sis targeted mutation 1, Shunsuke Ishii MGI:2387096 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no homozygous embryos found after E3.5
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• in vitro failure of embryos to divide after 16 cell stage or to form blastocoel
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only 56.5% of female mice and 42.9% of male mice survive 9,10-dimethyl-1,2-benzanthracene (DMBA) exposure and remain tumor free
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• one individual with tumors of the spleen
• no tumors were seen in 220 wild-type mice in the same colony
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• exposure to 9,10-dimethyl-1,2-benzanthracene (DMBA) results in increased incidence of malignant lymphomas in heterozygous mice
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• one individual with tumors of the pancreas
• no tumors were seen in 220 wild-type mice in the same colony
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• only 56.5% of female mice and 42.9% of male mice survive 9,10-dimethyl-1,2-benzanthracene (DMBA) exposure and remain tumor free
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• exposure to 9,10-dimethyl-1,2-benzanthracene (DMBA) results in increased incidence of malignant lymphomas in heterozygous mice
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• one individual with tumors of the spleen
• no tumors were seen in 220 wild-type mice in the same colony
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• one individual with tumors of the spleen
• no tumors were seen in 220 wild-type mice in the same colony
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• one individual with tumors of the spleen
• no tumors were seen in 220 wild-type mice in the same colony
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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