Phenotypes associated with this allele

• Allele Symbol: Dct^tm1(cre)Bee
• Allele Name: targeted mutation 1, Friedrich Beermann
• Allele ID: MGI:2387116
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dct^tm1(cre)Bee/Dct^tm1(cre)Bee	involves: 129/Sv * C57BL/6	MGI:3047146
cn2	Dct^tm1(cre)Bee/Dct^+ Rest^tm1.1Yasu/Rest^+	involves: 129/Sv * 129S4/SvJae * C57BL/6	MGI:6241494
cn3	Dct^tm1(cre)Bee/Dct^+ Rest^tm1.1Yasu/Rest^tm1.1Yasu	involves: 129/Sv * 129S4/SvJae * C57BL/6	MGI:6241506
cn4	Dct^tm1(cre)Bee/Dct^tm1(cre)Bee Tgfbr2^tm1Roes/Tgfbr2^tm1Roes Tg(Dct-lacZ)A12Jkn/0	involves: 129/Sv * C57BL/6 * C57BL/6J * CBA	MGI:6241339

Genotype
MGI:3047146

hm1

• Allelic Composition: Dct^tm1(cre)Bee/Dct^tm1(cre)Bee
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

diluted coat color ( J:89896 )

• dilute and lighter coat color is observed on both agouti and nonagouti backgrounds

• while the melanin content is reduced relative to wild-type mice, it is higher than in homozygous Dct^slt mice

vision/eye

vision/eye phenotype ( J:89896 )

N • eyes are histologically normal and no anomalies pertaining to pigmentation are observed

N • normal pigmentation of choroidal melanocytes

nervous system

nervous system phenotype ( J:89896 )

N • no abnormalities of the brain are observed

integument

integument phenotype ( J:89896 )

N • skin is histologically normal and no pigmentation abnormalities are observed

diluted coat color ( J:89896 )

• dilute and lighter coat color is observed on both agouti and nonagouti backgrounds

• while the melanin content is reduced relative to wild-type mice, it is higher than in homozygous Dct^slt mice

Genotype
MGI:6241494

cn2

• Allelic Composition: Dct^tm1(cre)Bee/Dct⁺; Rest^tm1.1Yasu/Rest⁺
• Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6

pigmentation

pigmentation phenotype ( J:230341 )

N • mice never form white spots including on the belly region

Genotype
MGI:6241506

cn3

• Allelic Composition: Dct^tm1(cre)Bee/Dct⁺; Rest^tm1.1Yasu/Rest^tm1.1Yasu
• Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6

pigmentation

head spot ( J:230341 )

• in rare cases (2 of 40), mice develop a small white spot on their forehead

integument

head spot ( J:230341 )

• in rare cases (2 of 40), mice develop a small white spot on their forehead

Genotype
MGI:6241339

cn4

• Allelic Composition: Dct^tm1(cre)Bee/Dct^tm1(cre)Bee; Tgfbr2^tm1Roes/Tgfbr2^tm1Roes; Tg(Dct-lacZ)A12Jkn/0
• Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * CBA

pigmentation

abnormal coat/hair pigmentation ( J:157070 )

• 73.3% of mice exhibit mild but accelerated hair graying within 10 months after birth relative to control mice; the frequency of gray hairs is variable depending on the individual mouse

• hair graying is likely caused by incomplete maintenance of melanocyte stem cells

abnormal hair follicle melanocyte morphology ( J:157070 )

• late anagen follicles exhibit LacZ+ dendritic and slightly pigmented melanocytes with large cell bodies in the bulge-subbulge area; in contrast, LacZ+ melanoblasts in the bulge area of control follicles are immature and small with minimal dendrites, typical features of melanocyte stem cells

• at 6 months of age, the frequency of hair follicles with large and dendritic melanocytes or pigmented melanocytes in the bulge area of anagen IV-VI follicles is significantly higher than that in control follicles

• some follicles show complete loss of Dct-lacZ+ cells in the bulge area, suggesting that melanocyte stem cells have prematurely differentiated and are eventually depleted from the stem cell niche

• melanocyte stem cells are lost in the bulge area of almost all follicles that produce white hair

• in contrast, the distribution of epidermal and dermal melanocytes in the pigmented junctional epithelium is normal

ectopic hair follicle melanin granules ( J:157070 )

• mice exhibit deposition of melanin pigment in the bulge area of midanagen hair follicles

pigment incontinence ( J:157070 )

• melanin incontinence in the dermal papillae of hair follicles occurs more frequently than in control follicles

ectopic melanocytes ( J:157070 )

• midanagen hair follicles begin to show ectopically pigmented melanocytes with dendritic morphologies starting from the second hair cycle

• ectopically differentiated melanocytes are preferentially seen in follicles that show pigmentation defects in the hair matrix

integument

abnormal coat/hair pigmentation ( J:157070 )

• 73.3% of mice exhibit mild but accelerated hair graying within 10 months after birth relative to control mice; the frequency of gray hairs is variable depending on the individual mouse

• hair graying is likely caused by incomplete maintenance of melanocyte stem cells

abnormal hair follicle melanocyte morphology ( J:157070 )

• late anagen follicles exhibit LacZ+ dendritic and slightly pigmented melanocytes with large cell bodies in the bulge-subbulge area; in contrast, LacZ+ melanoblasts in the bulge area of control follicles are immature and small with minimal dendrites, typical features of melanocyte stem cells

• at 6 months of age, the frequency of hair follicles with large and dendritic melanocytes or pigmented melanocytes in the bulge area of anagen IV-VI follicles is significantly higher than that in control follicles

• some follicles show complete loss of Dct-lacZ+ cells in the bulge area, suggesting that melanocyte stem cells have prematurely differentiated and are eventually depleted from the stem cell niche

• melanocyte stem cells are lost in the bulge area of almost all follicles that produce white hair

• in contrast, the distribution of epidermal and dermal melanocytes in the pigmented junctional epithelium is normal

ectopic hair follicle melanin granules ( J:157070 )

• mice exhibit deposition of melanin pigment in the bulge area of midanagen hair follicles

pigment incontinence ( J:157070 )

• melanin incontinence in the dermal papillae of hair follicles occurs more frequently than in control follicles