Phenotypes associated with this allele

• Allele Symbol: Lnpep^tm1Ske
• Allele Name: targeted mutation 1, Susanna R Keller
• Allele ID: MGI:2387151
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lnpep^tm1Ske/Lnpep^tm1Ske	B6.129S-Lnpep^tm1Ske	MGI:6116663
hm2	Lnpep^tm1Ske/Lnpep^tm1Ske	involves: 129S/SvEv * Black Swiss	MGI:3582359

Genotype
MGI:6116663

hm1

• Allelic Composition: Lnpep^tm1Ske/Lnpep^tm1Ske
• Genetic Background: B6.129S-Lnpep^tm1Ske

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased brown adipose tissue amount ( J:220356 )

• in mice fed a high-fat diet

decreased total body fat amount ( J:220356 )

• in mice fed a high-fat diet

decreased white fat cell lipid droplet size ( J:220356 )

• with reduced numbers of cells containing lipid droplets in ependymal fat pads

decreased white fat cell size ( J:220356 )

• in the abdominal fat of mice fed a high-fat diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:220356 )

N • mice exhibit normal basal levels of glucose, insulin, cholesterol, triglycerides or free fatty acids

N • mice exhibit normal adaptive thermogenesis

decreased susceptibility to diet-induced obesity ( J:220356 )

• in mice fed a high-fat diet

increased circulating leptin level ( J:220356 )

• in mice fed a high-fat diet

decreased circulating cholesterol level ( J:220356 )

• in mice fed a high-fat diet

increased core body temperature ( J:220356 )

• mild hyperthermia in rectal temperature with a 4-fold increase in UCP-1 (a key regulator of thermogenesis) levels in brown adipose tissue

increased oxygen consumption ( J:220356 )

improved glucose tolerance ( J:220356 )

• in mice fed a high-fat diet

increased insulin sensitivity ( J:220356 )

• in mice fed a high-fat diet

decreased circulating adiponectin level ( J:220356 )

• in mice fed a high-fat diet but not as much as in wild-type mice

growth/size/body

growth/size/body region phenotype ( J:220356 )

N • mice exhibit normal fat weight and body weight

decreased susceptibility to diet-induced obesity ( J:220356 )

• in mice fed a high-fat diet

Genotype
MGI:3582359

hm2

• Allelic Composition: Lnpep^tm1Ske/Lnpep^tm1Ske
• Genetic Background: involves: 129S/SvEv * Black Swiss

homeostasis/metabolism

abnormal glucose homeostasis ( J:76570 )

• insulin stimulated uptake of glucose by muscle was decreased

• basal uptake of glucose by adipocytes was reduced 30% in males and 45% in females

insulin resistance ( J:76570 )

• ability of insulin to lower blood glucose was modestly impaired

cardiovascular system

enlarged heart ( J:76570 )

• hearts of males about 20% larger than controls

growth/size/body

enlarged heart ( J:76570 )

• hearts of males about 20% larger than controls