Phenotypes associated with this allele

• Allele Symbol: Fos^tm1Mxu
• Allele Name: targeted mutation 1, Ming Xu
• Allele ID: MGI:2387304
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fos^tm1Mxu/Fos^tm1Mxu Tg(Drd1-cre)120Mxu/0	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J	MGI:3814565
cn2	Fos^tm1Mxu/Fos^tm1Mxu Tg(Camk2a-cre)T50Stl/0	involves: 129S2/SvPas * BALB/c * C57BL/6	MGI:3814562

Genotype
MGI:3814565

cn1

• Allelic Composition: Fos^tm1Mxu/Fos^tm1Mxu; Tg(Drd1-cre)120Mxu/0
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:116774 )

• repeated 20 mg/kg cocaine treatment does not induce behavioral sensitization in mutants, in contrast to wild-type; sensitized grooming behavior develops to similar extent in mutant and wild-type animals

abnormal learning/memory/conditioning ( J:116774 )

• mutants exhibit more persistent memory for reinforcing effects of cocaine than wild-type mice

impaired conditioned place preference behavior ( J:116774 )

• cocaine-induced conditioned place preference behavior does not extinguish until 22 days of training compared to 12 (and 16) days of training in wild-type

abnormal locomotor activation ( J:116774 )

• 20 mg/kg cocaine treatment induces rearing in controls and mutants, but mutants show lower activity than controls; with repeated injections, wild-type mice develop sensitized rearing but mutants do not

nervous system

abnormal dendrite morphology ( J:116774 )

• repeated cocaine injections increase dendritic spine density on medium spiny neurons in the nucleus accumbens and caudate putamen of wild-type mice, but mutant brains show lower spine densities

abnormal neuron number ( J:116774 )

• repeated cocaine injections increase the number of dendrites in the cortex of wild-type mice, but mutants have significantly lower dendritic number

Genotype
MGI:3814562

cn2

• Allelic Composition: Fos^tm1Mxu/Fos^tm1Mxu; Tg(Camk2a-cre)T50Stl/0
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

nervous system

abnormal nervous system electrophysiology ( J:108041 )

• population spike amplitude evoked by minimal stimulation intensity is significantly larger in hippocampal mutant slices compared to wild-type slices with a large increase in cellular excitability and a larger maximal response

• >60% of slices show epileptiform activity following low intensity stimulation compared to <40% of wild-type

• very low concentration kainic acid (KA) stimulation of hippocampal slices produces maximal CA3 population spike amplitude and higher concentrations induces severe epileptiform activity, reducing amplitude of the population response