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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcf3tm1Zhu
targeted mutation 1, Yuan Zhuang
MGI:2387348
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcf3tm1Zhu/Tcf3tm1Zhu involves: 129 MGI:3776840
hm2
 		Tcf3tm1Zhu/Tcf3tm1Zhu involves: 129 * C57BL/6J MGI:3803026
ht3
 		Tcf3tm1Zhu/Tcf3tm2Zhu involves: 129 * C57BL/6 MGI:3776842
cx4
 		Tcf4tm1Zhu/Tcf4+
Tcf3tm1Zhu/Tcf3+ 		involves: 129P2/OlaHsd MGI:3776854


Genotype
MGI:3776840
hm1
Allelic
Composition		 Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1Zhu mutation (0 available); any Tcf3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:125313 )
N
• the pontine nucleus develops normally

mortality/aging
premature death ( J:47671 )
• survival rates are lower than normal but higher than in Tcfe2a null mice

reproductive system

hematopoietic system
decreased B cell number ( J:47671 )
• less than 10% of B cell numbers are found in mice
• however, B cell commitment occurs normally
abnormal hematopoietic stem cell morphology ( J:47671 )
• hematopoietic stem cells fail to repopulate an irradiated mouse with B cells
• however, T cell development is normal

immune system
decreased B cell number ( J:47671 )
• less than 10% of B cell numbers are found in mice
• however, B cell commitment occurs normally




Genotype
MGI:3803026
hm2
Allelic
Composition		 Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1Zhu mutation (0 available); any Tcf3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:136143 )
• thymi cultured for 7 days exhibit reduced total cell numbers compared to wild-type thymi
increased single-positive T cell number ( J:136143 )
• the proportion of single positive T cells is increased compared to in wild-type mice

hematopoietic system
thymus hypoplasia ( J:136143 )
• thymi cultured for 7 days exhibit reduced total cell numbers compared to wild-type thymi
increased single-positive T cell number ( J:136143 )
• the proportion of single positive T cells is increased compared to in wild-type mice

endocrine/exocrine glands
thymus hypoplasia ( J:136143 )
• thymi cultured for 7 days exhibit reduced total cell numbers compared to wild-type thymi




Genotype
MGI:3776842
ht3
Allelic
Composition		 Tcf3tm1Zhu/Tcf3tm2Zhu
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1Zhu mutation (0 available); any Tcf3 mutation (43 available)
Tcf3tm2Zhu mutation (0 available); any Tcf3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:47671 )
• small numbers of B cells are detected in neonates but not in adults

immune system
decreased B cell number ( J:47671 )
• small numbers of B cells are detected in neonates but not in adults




Genotype
MGI:3776854
cx4
Allelic
Composition		 Tcf4tm1Zhu/Tcf4+
Tcf3tm1Zhu/Tcf3+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1Zhu mutation (0 available); any Tcf3 mutation (43 available)
Tcf4tm1Zhu mutation (0 available); any Tcf4 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:125313 )
N
• the pontine nucleus develops normally




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory