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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcf3tm2Zhu
targeted mutation 2, Yuan Zhuang
MGI:2387351
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcf3tm2Zhu/Tcf3tm2Zhu involves: 129 * C57BL/6 MGI:3776841
hm2
 		Tcf3tm2Zhu/Tcf3tm2Zhu involves: 129/Sv * C57BL/6 MGI:4399148
ht3
 		Tcf3tm1Zhu/Tcf3tm2Zhu involves: 129 * C57BL/6 MGI:3776842


Genotype
MGI:3776841
hm1
Allelic
Composition		 Tcf3tm2Zhu/Tcf3tm2Zhu
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm2Zhu mutation (0 available); any Tcf3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:47671 )
N
• unlike Tcfe2a null mice, survival rates are normal

hematopoietic system
decreased pro-B cell number ( J:47671 )
• 10-fold in the bone marrow and 20-fold in the spleen of neonates
• however, B cell numbers recover during adulthood
decreased pre-B cell number ( J:47671 )
• 10-fold in the bone marrow and 20-fold in the spleen of neonates
• however, B cell numbers recover during adulthood
abnormal hematopoietic stem cell morphology ( J:47671 )
• hematopoietic stem cells fail to repopulate an irradiated mouse with B cells
• however, T cell development is normal

reproductive system
reproductive system phenotype ( J:47671 )
N
• unlike Tcfe2a null mice, males and female mice are fertile

immune system
decreased pro-B cell number ( J:47671 )
• 10-fold in the bone marrow and 20-fold in the spleen of neonates
• however, B cell numbers recover during adulthood
decreased pre-B cell number ( J:47671 )
• 10-fold in the bone marrow and 20-fold in the spleen of neonates
• however, B cell numbers recover during adulthood




Genotype
MGI:4399148
hm2
Allelic
Composition		 Tcf3tm2Zhu/Tcf3tm2Zhu
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm2Zhu mutation (0 available); any Tcf3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:154788 )
• upon backcrossing to C57BL/6

growth/size/body
decreased body size ( J:154788 )
• upon backcrossing to C57BL/6, mice become smaller in size compared with wild-type mice




Genotype
MGI:3776842
ht3
Allelic
Composition		 Tcf3tm1Zhu/Tcf3tm2Zhu
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1Zhu mutation (0 available); any Tcf3 mutation (43 available)
Tcf3tm2Zhu mutation (0 available); any Tcf3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:47671 )
• small numbers of B cells are detected in neonates but not in adults

immune system
decreased B cell number ( J:47671 )
• small numbers of B cells are detected in neonates but not in adults




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory