Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tcf4tm1Zhu targeted mutation 1, Yuan Zhuang MGI:2387399 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die within the first 24 hours of birth but no embryonic lethality is observed as previously noted
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• the pontine nuclei is disrupted
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes born with low frequency and died within one week of birth
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• 50% reduction in the number of pro-B cells in homozygotes
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• 50% reduction in the number of pro-B cells in homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show reduced freezing in the contextual fear conditioning tests
• mice treated subchronically with suberoylanilide hydroxamic acid show rescue of memory-associated freezing in the contextual and cued tests
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• mice show reduced freezing in the cued fear conditioning test
• mice treated subchronically with suberoylanilide hydroxamic acid show rescue of memory-associated freezing in the contextual and cued tests
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• in the Morris water maze, mice fail to show selectivity for the target quadrant, spending less time there than wild-type mice and crossing the platform zone fewer times
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• mice have a deficit in the 24 hour object location memory indicating impaired spatial memory
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• mice groom themselves more than wild-type mice
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• mice exhibit enhanced startle reflex to unexpected 120 dB sound bursts
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• mice exhibit asymmetry in their motor control and an imbalance that favors their left size
• however, mice show no differences on the rotating rod or in walking across a horizontal ladder
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• mice show weaker hindlimb, but not forelimb, grip strength
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• mice favor their front left paw while ambulating across a catwalk
• dynamic weight bearing analysis indicates that mice place more weight on their front left paw than their right paw
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• mice show increased activity in the open field and in the elevated plus maze, where mice show an increase in overall arm entrances
• however, mice do not show an increase in anxiety in the open field or elevated plus maze
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• mice prefer social isolation over interaction with a novel mouse in the three-chamber social test
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• pups have reduced ultrasonic vocalization when removed from the nest, which remains low until the phenotype converges with normal behavior or wild-type controls around P7
• P3 pups have weaker calls
• P3 pups have less frequent ultrasonic distress calls and at lower volumes
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• mice exhibit enhanced Schaffer collateral long-term potentiation when activated with theta burst stimulation
• hippocampal CA1 area treated with the HDAC inhibitor Trichostatin A before theta burst stimulation normalizes the LTP
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• mice have deficits in prepulse inhibition
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Pitt-Hopkins syndrome | DOID:0060488 |
OMIM:610954 |
J:239016 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer thymocytes with the Tcf4tm1Hmb allele are detected
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• fewer B220-CD3- B cells with the Tcf4tm1Hmb allele are detected
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• fewer immature CD4+CD8+ T cells with the Tcf4tm1Hmb allele are detected
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• fewer splenocytes with the Tcf4tm1Hmb allele are detected
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• fewer thymocytes with the Tcf4tm1Hmb allele are detected
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• fewer B220-CD3- B cells with the Tcf4tm1Hmb allele are detected
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• fewer immature CD4+CD8+ T cells with the Tcf4tm1Hmb allele are detected
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• fewer splenocytes with the Tcf4tm1Hmb allele are detected
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• fewer thymocytes with the Tcf4tm1Hmb allele are detected
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice die within the first 24 hours of birth but no embryonic lethality is observed as previously noted
|
|
• the pontine nuclei is disrupted
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most homozygotes died within two weeks of birth
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• evident after birth
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• 70% reduction in the number of pro-B cells
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• 70% reduction in the number of pro-B cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most homozygotes died within two weeks of birth
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• evident after birth
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• 50% reduction in the number of pro-B cells
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• 50% reduction in the number of pro-B cells
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| N |
• the pontine nucleus develops normally
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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