Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tcf12tm1Zhu targeted mutation 1, Yuan Zhuang MGI:2387400 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most homozygotes died within two weeks of birth
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• 50% reduction in the number of pro-B cells in homozygote
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• 50% reduction in the number of pro-B cells in homozygote
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• thymocyte number is reduced 10-fold relative to controls in 2-3 week old mice
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• block in development at the immature single positive (ISP) stage
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• thymocyte number is reduced 10-fold relative to controls in 2-3 week old mice
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• block in development at the immature single positive (ISP) stage
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| N |
• the pontine nucleus develops normally
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• thymocyte number is reduced 10-fold relative to controls in 2-3 week old mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• thymi cultured for 7 days exhibit reduced total cell numbers compared to wild-type thymi
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• most pronounced in DN3 cells
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• thymi cultured for 7 days exhibit reduced total cell numbers compared to wild-type thymi
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• most pronounced in DN3 cells
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• thymi cultured for 7 days exhibit reduced total cell numbers compared to wild-type thymi
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• T cell development can proceed to the ISP stage but not to the single positive (SP) stage
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• T cell development can proceed to the ISP stage but not to the single positive (SP) stage
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• there is a developmental block between the double negative and immature single positive stages of T cell development
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• 2-week old mice exhibit a dramatic accumulation of double negative T cells
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• 2-week old mice exhibit a dramatic accumulation of immature single positive T cells
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• there is a developmental block between the double negative and immature single positive stages of T cell development
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• 2-week old mice exhibit a dramatic accumulation of double negative T cells
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• 2-week old mice exhibit a dramatic accumulation of immature single positive T cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most homozygotes died within two weeks of birth
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• evident after birth
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• 50% reduction in the number of pro-B cells
|
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• 50% reduction in the number of pro-B cells
|
| N |
• the pontine nucleus develops normally
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• most homozygotes died within two weeks of birth
|
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• evident after birth
|
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• 70% reduction in the number of pro-B cells
|
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• 70% reduction in the number of pro-B cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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