Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Fabp4-cre/ERT2)1Ipc transgene insertion 1, I Pierre Chambon MGI:2387425 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• mice exhibit normal brown adipose tissue morphology with reduced body weight compared to single Tyk2 homozygotes
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N |
• mice exhibit improved insulin sensitivity compared to single Tyk2 homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• iBAT weights are about 30% lower than in controls after tamoxifen administration to induce Cre expression
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• presence of numerous necrotic brown adipocytes with swollen and hypertrophic mitochondria and fibroblasts and collagen fibers at 14 days post tamoxifen administration
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• at 4 days after tamoxifen administration, about 30% of brown adipocytes contain larger lipid droplets than in controls
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• presence of numerous necrotic white adipocytes after tamoxifen administration, with some containing supernumerary small lipid droplets, infiltration by lymphocytes and macrophages, and disrupted cell membranes
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• epididymal fat pad weights are about 30% lower than in controls after tamoxifen administration to induce Cre expression
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• 17-25% reduction in the relative body fat content for 7 to 21 days after tamoxifen administration, however by 42 and 49 days after tamoxifen administration, body fat content is normal
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• mature brown and white adipocytes die within a few days after tamoxifen administration and are replaced with Pparg-positive adipocytes putatively derived from fibroblast-like preadipocyte cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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