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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfsf13btm1Msc
targeted mutation 1, Martin L Scott
MGI:2387426
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnfsf13btm1Msc/Tnfsf13btm1Msc involves: 129S2/SvPas MGI:3718130
hm2
 		Tnfsf13btm1Msc/Tnfsf13btm1Msc involves: 129S2/SvPas * C57BL/6 MGI:3036466
ht3
 		Tnfsf13btm1Msc/Tnfsf13b+ involves: 129S2/SvPas * C57BL/6 MGI:3036467
cn4
 		Cd19tm1(cre)Cgn/Cd19+
Tnfsf13btm1Msc/Tnfsf13btm1Msc
Traf2tm1Rbr/Traf2tm1Rbr 		involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:3777352
cx5
 		Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Tnfsf13btm1Msc/Tnfsf13btm1Msc 		involves: 129 * 129S2/SvPas * BALB/c MGI:3511169
cx6
 		Tnfsf13btm1Msc/Tnfsf13btm1Msc
Traf2tm1Rbr/Traf2tm1Rbr 		involves: 129S2/SvPas * C57BL/6 MGI:3777351


Genotype
MGI:3718130
hm1
Allelic
Composition		 Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf13btm1Msc mutation (1 available); any Tnfsf13b mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:92334 )
• reduction in CD4+ T cell proliferation is not as severe as in Tnfrsf13cBcmd1-A/WySnJ homozygotes
• a synergistic decreased in CD4+ T cell proliferation occurs when mice are treated with cyclosporine A
decreased B cell number ( J:138560 )
• total splenic B cells, transitional B cells and follicular B cells are reduced in the spleen
increased length of allograft survival ( J:92334 )
• MHC-mismatched allograft survival is marginally increased compared to in wild-type mice
• MHC-mismatched allograft survival is considerably increased with the use of cyclosporine A compared to wild-type and Igh-6tm1Cgn homozygotes

hematopoietic system
decreased T cell proliferation ( J:92334 )
• reduction in CD4+ T cell proliferation is not as severe as in Tnfrsf13cBcmd1-A/WySnJ homozygotes
• a synergistic decreased in CD4+ T cell proliferation occurs when mice are treated with cyclosporine A
decreased B cell number ( J:138560 )
• total splenic B cells, transitional B cells and follicular B cells are reduced in the spleen

cellular
decreased T cell proliferation ( J:92334 )
• reduction in CD4+ T cell proliferation is not as severe as in Tnfrsf13cBcmd1-A/WySnJ homozygotes
• a synergistic decreased in CD4+ T cell proliferation occurs when mice are treated with cyclosporine A




Genotype
MGI:3036466
hm2
Allelic
Composition		 Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf13btm1Msc mutation (1 available); any Tnfsf13b mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:71681 )
• apparently at the T1 to T2 transition in splenic B cells (CD21 lo, IgMhi)
• apparently at the B1 to B2 transition in cells recovered from peritoneal lavage (B220+, CD23lo)
decreased B cell number ( J:71681 )
• severe losses of B220+ cells in secondary lymphoid tissue
decreased follicular B cell number ( J:71681 )
• fewer follicular B cells than controls in spleen
decreased marginal zone B cell number ( J:71681 )
• spleens had significantly fewer B cells in the marginal zone than in controls
decreased spleen weight ( J:71681 )
• necropsy at 6 - 8 months of age showed significantly reduced average spleen weights
decreased immunoglobulin level ( J:71681 )
• 10-fold decrease in baseline total serum immunoglobulin concentration
• all Ig subclasses significantly reduced at baseline, with the exception of IgA, which was moderately reduced
• decreased immunoglobulin production after both T-dependent and T-independent immunization

immune system
arrested B cell differentiation ( J:71681 )
• apparently at the T1 to T2 transition in splenic B cells (CD21 lo, IgMhi)
• apparently at the B1 to B2 transition in cells recovered from peritoneal lavage (B220+, CD23lo)
decreased B cell number ( J:71681 )
• severe losses of B220+ cells in secondary lymphoid tissue
decreased follicular B cell number ( J:71681 )
• fewer follicular B cells than controls in spleen
decreased marginal zone B cell number ( J:71681 )
• spleens had significantly fewer B cells in the marginal zone than in controls
decreased spleen weight ( J:71681 )
• necropsy at 6 - 8 months of age showed significantly reduced average spleen weights
abnormal lymph node B cell domain morphology ( J:71681 )
• abnormal B cell domain, with ~10-fold reduction in B cell numbers
abnormal humoral immune response ( J:71681 )
• decreased immunoglobulin production after both T-dependent and T-independent immunization
decreased immunoglobulin level ( J:71681 )
• 10-fold decrease in baseline total serum immunoglobulin concentration
• all Ig subclasses significantly reduced at baseline, with the exception of IgA, which was moderately reduced
• decreased immunoglobulin production after both T-dependent and T-independent immunization




Genotype
MGI:3036467
ht3
Allelic
Composition		 Tnfsf13btm1Msc/Tnfsf13b+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf13btm1Msc mutation (1 available); any Tnfsf13b mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased immunoglobulin level ( J:71681 )
• ~2-fold decrease in total serum immunoglobulin concentration at baseline

hematopoietic system
decreased immunoglobulin level ( J:71681 )
• ~2-fold decrease in total serum immunoglobulin concentration at baseline




Genotype
MGI:3777352
cn4
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Tnfsf13btm1Msc/Tnfsf13btm1Msc
Traf2tm1Rbr/Traf2tm1Rbr
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Tnfsf13btm1Msc mutation (1 available); any Tnfsf13b mutation (30 available)
Traf2tm1Rbr mutation (0 available); any Traf2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased follicular B cell number ( J:132877 )
• there is about a 4-fold increase in the number of follicular B cells found in the spleen compared to controls
increased marginal zone B cell number ( J:132877 )
• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes

hematopoietic system
increased follicular B cell number ( J:132877 )
• there is about a 4-fold increase in the number of follicular B cells found in the spleen compared to controls
increased marginal zone B cell number ( J:132877 )
• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes




Genotype
MGI:3511169
cx5
Allelic
Composition		 Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic
Background		 involves: 129 * 129S2/SvPas * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf13btm1Msc mutation (1 available); any Tnfsf13b mutation (30 available)
Traf3ip2tm1.1Lix mutation (0 available); any Traf3ip2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
enlarged spleen ( J:93923 )
• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes
decreased B cell number ( J:138560 )
• total splenic B cells, transitional B cells and follicular B cells are reduced in the spleen
decreased mature B cell number ( J:138560 )
• total number of mature B cells is reduced

immune system
enlarged spleen ( J:93923 )
• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes
decreased B cell number ( J:138560 )
• total splenic B cells, transitional B cells and follicular B cells are reduced in the spleen
decreased mature B cell number ( J:138560 )
• total number of mature B cells is reduced
enlarged lymph nodes ( J:93923 )
• enlargement of the lymph nodes is reduced compared to Traf3ip2 single homozygotes
increased autoantibody level ( J:138560 )
• mutants develop anti-SSA/Ro and anti-SSB/La autoantibodies in response to recombinant SSA/Ro and SSB/La antigens, although to a lower level than in Traf3ip2 single homozygotes due to the low number of B cells, but higher levels than in Tnfsf13b single homozygotes

growth/size/body
enlarged spleen ( J:93923 )
• enlargement of the spleen is reduced compared to Traf3ip2 single homozygotes
• immunoglobulin levels are normal unlike in Traf3ip2 single homozygotes




Genotype
MGI:3777351
cx6
Allelic
Composition		 Tnfsf13btm1Msc/Tnfsf13btm1Msc
Traf2tm1Rbr/Traf2tm1Rbr
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf13btm1Msc mutation (1 available); any Tnfsf13b mutation (30 available)
Traf2tm1Rbr mutation (0 available); any Traf2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased mature B cell number ( J:132877 )
• mature B cells are virtually absent from the lymph nodes
absent follicular B cells ( J:132877 )
• follicular B cells are absent from the spleen
absent marginal zone B cells ( J:132877 )
• marginal zone B cells are absent from the spleen

hematopoietic system
decreased mature B cell number ( J:132877 )
• mature B cells are virtually absent from the lymph nodes
absent follicular B cells ( J:132877 )
• follicular B cells are absent from the spleen
absent marginal zone B cells ( J:132877 )
• marginal zone B cells are absent from the spleen




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory