mortality/aging
• mutant embryos exhibit abnormalities and die prior to E5.5
• the percentage of resorptions at E8.5 is as high as 25%
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embryo
• at E5.5, mutant embryos are significantly smaller than wild-type embryos
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• mutant embryos lack identifiable morphology and embryonic cells appear apoptotic
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growth/size/body
• at E5.5, mutant embryos are significantly smaller than wild-type embryos
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