Phenotypes associated with this allele

• Allele Symbol: Wnt7b^tm1Parr
• Allele Name: targeted mutation 1, Brian A Parr
• Allele ID: MGI:2387443
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wnt7b^tm1Parr/Wnt7b^tm1Parr	involves: 129S1/Sv	MGI:2653625
cn2	Twist2^tm1(cre)Dor/Twist2^+ Wnt7b^tm1Parr/Wnt7b^tm2Amc	involves: 129S1/Sv * 129X1/SvJ	MGI:3841730
cn3	Edil3^Tg(Sox2-cre)1Amc/Edil3^+ Wnt7a^tm1Amc/Wnt7a^tm1Amc Wnt7b^tm1Parr/Wnt7b^tm2Amc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3831189
cn4	Tg(Nes-cre)1Kln/0 Wnt7a^tm1Amc/Wnt7a^tm1Amc Wnt7b^tm1Parr/Wnt7b^tm2Amc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3831188

Genotype
MGI:2653625

hm1

• Allelic Composition: Wnt7b^tm1Parr/Wnt7b^tm1Parr
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:71583 )

• dead by E11.5

embryo

abnormal chorion morphology ( J:71583 )

• disorganized

abnormal placenta development ( J:71583 )

abnormal chorioallantoic fusion ( J:71583 )

Genotype
MGI:3841730

cn2

• Allelic Composition: Twist2^tm1(cre)Dor/Twist2⁺; Wnt7b^tm1Parr/Wnt7b^tm2Amc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

skeleton

abnormal osteoblast differentiation ( J:117333 )

• calvaria cells from neonates and bone marrow stromal cells from adults produce fewer bone nodules than wild-type cells

decreased width of hypertrophic chondrocyte zone ( J:117333 )

• at E15.5

abnormal bone ossification ( J:117333 )

• at E15.5, ossification if diminished compared to in wild-type mice

• bone collars of long bones are shorter than in wild-type mice

• at E18.5, skulls exhibit decreased ossification compared to in wild-type mice

cellular

abnormal osteoblast differentiation ( J:117333 )

• calvaria cells from neonates and bone marrow stromal cells from adults produce fewer bone nodules than wild-type cells

Genotype
MGI:3831189

cn3

• Allelic Composition: Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺; Wnt7a^tm1Amc/Wnt7a^tm1Amc; Wnt7b^tm1Parr/Wnt7b^tm2Amc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:142352 )

• all embryos die around E12.5 due to severe hemorrhaging within the central nervous system

cardiovascular system

abnormal vasculogenesis ( J:142352 )

• while vascularization has occurred within the ventral neural tube of control E10.5 embryos at the forelimb level, no such vascularization is observed in this region of mutant embryos

• in E12.5 embryos, endothelial cells and pericytes are absent from all ventral neural regions of the presumptive spinal cord except for in the floor plate

• in the dorsal neural tube of E12.5 embryos, endothelial cells and pericytes form abnormal clusters and enlarged lumens in the vascular structures present

intracranial hemorrhage ( J:142352 )

• hemorrhaging is detected throughout the developing brain of E12.5 embryos

spinal hemorrhage ( J:142352 )

• hemorrhaging is detected throughout the developing spine of E12.5 embryos

abnormal blood-brain barrier function ( J:142352 )

• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos

nervous system

intracranial hemorrhage ( J:142352 )

• hemorrhaging is detected throughout the developing brain of E12.5 embryos

spinal hemorrhage ( J:142352 )

• hemorrhaging is detected throughout the developing spine of E12.5 embryos

abnormal blood-brain barrier function ( J:142352 )

• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos

Genotype
MGI:3831188

cn4

• Allelic Composition: Tg(Nes-cre)1Kln/0; Wnt7a^tm1Amc/Wnt7a^tm1Amc; Wnt7b^tm1Parr/Wnt7b^tm2Amc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:142352 )

• all embryos die around E12.5 due to severe hemorrhaging within the central nervous system

cardiovascular system

abnormal vasculogenesis ( J:142352 )

• the number of endothelial cells and pericytes present in the intraneural vascular plexus of E12.5 embryos is greatly reduced

intracranial hemorrhage ( J:142352 )

• hemorrhaging is detected throughout the developing brain of E12.5 embryos

spinal hemorrhage ( J:142352 )

• hemorrhaging is detected throughout the developing spine of E12.5 embryos

abnormal blood-brain barrier function ( J:142352 )

• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos

nervous system

intracranial hemorrhage ( J:142352 )

• hemorrhaging is detected throughout the developing brain of E12.5 embryos

spinal hemorrhage ( J:142352 )

• hemorrhaging is detected throughout the developing spine of E12.5 embryos

abnormal blood-brain barrier function ( J:142352 )

• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos