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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zeb2tm1.2Yhi
targeted mutation 1.2, Yujiro Higashi
MGI:2387501
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zeb2tm1.2Yhi/Zeb2tm1.2Yhi involves: 129S1/Sv * 129X1/SvJ MGI:3624724
hm2
 		Zeb2tm1.2Yhi/Zeb2tm1.2Yhi involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3624726
hm3
 		Zeb2tm1.2Yhi/Zeb2tm1.2Yhi involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3814384
hm4
 		Zeb2tm1.2Yhi/Zeb2tm1.2Yhi involves: 129S1/Sv * 129X1/SvJ * ICR MGI:3624734
ht5
 		Zeb2tm1.2Yhi/Zeb2+ involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3624727
cx6
 		Zeb1tm2Yhi/Zeb1tm2Yhi
Zeb2tm1.2Yhi/Zeb2+ 		involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR MGI:3653750
cx7
 		Zeb1tm2Yhi/Zeb1+
Zeb2tm1.2Yhi/Zeb2+ 		involves: 129S1/Sv * 129X1/SvJ * ICR MGI:3653728


Genotype
MGI:3624724
hm1
Allelic
Composition		 Zeb2tm1.2Yhi/Zeb2tm1.2Yhi
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zeb2tm1.2Yhi mutation (1 available); any Zeb2 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3624726
hm2
Allelic
Composition		 Zeb2tm1.2Yhi/Zeb2tm1.2Yhi
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zeb2tm1.2Yhi mutation (1 available); any Zeb2 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal neural plate morphology ( J:82084 )
• a sharp boundary between the neural plate and the rest of the ectoderm is absent
absent vagal neural crest cells ( J:82084 )
• lack postotic vagal level neural crest cells
open neural tube ( J:82084 )
• neural tube fails to close

embryo
abnormal cranial neural crest cell migration ( J:82084 )
• cranial neural crest cells do not delaminate nor do they initiate migration
abnormal neural crest cell delamination ( J:82084 )
• cranial neural crest cells do not delaminate at the junctional zone between the neural and surface ectoderm
absent first pharyngeal arch ( J:82084 )
• the first branchial arch is missing
incomplete embryo turning ( J:82084 )
• do not undergo embryonic turning
embryonic growth arrest ( J:82084 )
• embryos are severely retarded in growth by E9.5
abnormal neural plate morphology ( J:82084 )
• a sharp boundary between the neural plate and the rest of the ectoderm is absent
absent vagal neural crest cells ( J:82084 )
• lack postotic vagal level neural crest cells
open neural tube ( J:82084 )
• neural tube fails to close

craniofacial
absent first pharyngeal arch ( J:82084 )
• the first branchial arch is missing

cellular
abnormal cranial neural crest cell migration ( J:82084 )
• cranial neural crest cells do not delaminate nor do they initiate migration
abnormal neural crest cell delamination ( J:82084 )
• cranial neural crest cells do not delaminate at the junctional zone between the neural and surface ectoderm

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Mowat-Wilson syndrome DOID:0060485 OMIM:235730
 J:82084




Genotype
MGI:3814384
hm3
Allelic
Composition		 Zeb2tm1.2Yhi/Zeb2tm1.2Yhi
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zeb2tm1.2Yhi mutation (1 available); any Zeb2 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal embryo development ( J:75138 )
• embryos exhibit variety of defects at E8.5




Genotype
MGI:3624734
hm4
Allelic
Composition		 Zeb2tm1.2Yhi/Zeb2tm1.2Yhi
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zeb2tm1.2Yhi mutation (1 available); any Zeb2 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal neural plate morphology ( J:108819 )
• defects in neural plate as shown by decreased Sox2 expression
open neural tube ( J:108819 )
• dorsal neural tube fails to close at E8.5
abnormal somite development ( J:101031 , J:108819 )
• somite cleavage stops at somite 7 while embryo elongation continues (J:108819)
abnormal somite shape ( J:101031 )
• at the 7-somite stage, somites are irregular in the shape of their boundary
decreased somite size ( J:101031 , J:108819 )
• at the 7-somite stage, the somites are shorter in the rostro-caudal dimension, however the size of somites in the lateral dimension is normal (J:101031)

nervous system
abnormal neural plate morphology ( J:108819 )
• defects in neural plate as shown by decreased Sox2 expression
open neural tube ( J:108819 )
• dorsal neural tube fails to close at E8.5




Genotype
MGI:3624727
ht5
Allelic
Composition		 Zeb2tm1.2Yhi/Zeb2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zeb2tm1.2Yhi mutation (1 available); any Zeb2 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:82084 )
N
• do not develop aganglionic phenotypes phenotypes similar to patients with Mowat-Wilson Syndrome (Hirschsprung disease-mental retardation syndrome)

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT Mowat-Wilson syndrome DOID:0060485 OMIM:235730
 J:82084




Genotype
MGI:3653750
cx6
Allelic
Composition		 Zeb1tm2Yhi/Zeb1tm2Yhi
Zeb2tm1.2Yhi/Zeb2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zeb1tm2Yhi mutation (1 available); any Zeb1 mutation (65 available)
Zeb2tm1.2Yhi mutation (1 available); any Zeb2 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

craniofacial
midline facial cleft ( J:108819 )
• 14 of 16 exhibit maxillonasal clefts of varying severity, ranging from incomplete fusion of the maxillonasal processes to complete cleft of the processes

nervous system
open neural tube ( J:108819 )
• the spinal cord is dorsally open in the tail region
abnormal brain ventricle morphology ( J:108819 )
• in the cerebrum, the shape of the ventricle is irregular, lined by a wavy ventricular zone
exencephaly ( J:108819 )
• 8 of 16 exhibit exencephaly accompanied by the cerebrum defects

embryo
open neural tube ( J:108819 )
• the spinal cord is dorsally open in the tail region

growth/size/body
midline facial cleft ( J:108819 )
• 14 of 16 exhibit maxillonasal clefts of varying severity, ranging from incomplete fusion of the maxillonasal processes to complete cleft of the processes




Genotype
MGI:3653728
cx7
Allelic
Composition		 Zeb1tm2Yhi/Zeb1+
Zeb2tm1.2Yhi/Zeb2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zeb1tm2Yhi mutation (1 available); any Zeb1 mutation (65 available)
Zeb2tm1.2Yhi mutation (1 available); any Zeb2 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:108819 )

reproductive system
vagina atresia ( J:108819 )
• 70% exhibit closure of the vaginal orifice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory