Phenotypes associated with this allele

• Allele Symbol: Tg(CMV-cre/ERT)1Ipc
• Allele Name: transgene insertion 1, I Pierre Chambon
• Allele ID: MGI:2387570
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tph2^tm2.1Pasq/Tph2^tm2.2Pasq Tg(CMV-cre/ERT)1Ipc/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5823236
cn2	Kras^tm1Bbd/Kras^+ Tg(CMV-cre/ERT)1Ipc/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3582837
cn3	Rarg^tm3Ipc/Rarg^tm3Ipc Tg(CMV-cre/ERT)1Ipc/0	involves: C57BL/6 * SJL	MGI:3629391

Genotype
MGI:5823236

cn1

• Allelic Composition: Tph2^tm2.1Pasq/Tph2^tm2.2Pasq; Tg(CMV-cre/ERT)1Ipc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased serotonin level ( J:238619 )

• reduced in the brain of tamoxifen-treated mice

Genotype
MGI:3582837

cn2

• Allelic Composition: Kras^tm1Bbd/Kras⁺; Tg(CMV-cre/ERT)1Ipc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

mortality/aging

premature death ( J:86101 )

• double mutants treated with 4-hydroxy-tamoxifen at 10 days of age develop breathing difficulties after 7 - 8 months of age

neoplasm

increased lung adenoma incidence ( J:86101 )

• after treatment with 4-hydroxy-tamoxifen at 10 days of age, a large spectrum of multifocal lesions are seen in the lung at 7-8 months of age including; small patches of bronchiolo-alveolar hyperplasias to large bronchiolo-alveolar adenomas that compress adjacent lung structures and appear to derive from type II pneumocytes

increased lung adenocarcinoma incidence ( J:86101 )

• after treatment with 4-hydroxy-tamoxifen at 10 days of age, at 7-8 months of age large bronchiolo-alveolar adenocarcinomas that compress adjacent lung structures and appear to derive from type II pneumocytes are seen

cellular

abnormal fibroblast proliferation ( J:86101 )

• MEFs expressing the oncogenic protein do not undergo proliferative senescence and proliferate continuously as immortal cells

respiratory system

increased lung adenoma incidence ( J:86101 )

• after treatment with 4-hydroxy-tamoxifen at 10 days of age, a large spectrum of multifocal lesions are seen in the lung at 7-8 months of age including; small patches of bronchiolo-alveolar hyperplasias to large bronchiolo-alveolar adenomas that compress adjacent lung structures and appear to derive from type II pneumocytes

increased lung adenocarcinoma incidence ( J:86101 )

• after treatment with 4-hydroxy-tamoxifen at 10 days of age, at 7-8 months of age large bronchiolo-alveolar adenocarcinomas that compress adjacent lung structures and appear to derive from type II pneumocytes are seen

respiratory distress ( J:86101 )

• double mutants treated with 4-hydroxy-tamoxifen at 10 days of age develop breathing difficulties after 7 - 8 months of age

endocrine/exocrine glands

Harderian gland hyperplasia ( J:86101 )

• hyperplastic Harderian gland seen in double mutants treated with 4-hydroxy-tamoxifen at 10 days of age

Genotype
MGI:3629391

cn3

• Allelic Composition: Rarg^tm3Ipc/Rarg^tm3Ipc; Tg(CMV-cre/ERT)1Ipc/0
• Genetic Background: involves: C57BL/6 * SJL

integument

abnormal skin morphology ( J:109090 )

• phenotype of adult mutant epidermis is identical to that observed in Rarg^tm1Ipc newborns

• skin from adult mice with selective Rarg ablation in the suprabasal layer upon tamoxifen treatment displays a smooth surface with small or lacking corneodesmosomes (CDs), compared to wild-type which have numerous regularly spaced plaques corresponding to CDs

abnormal epidermis stratum corneum morphology ( J:109090 )

• in mutants neutral lipids are distributed unevenly along the cornified layer of the epidermis

abnormal keratinocyte morphology ( J:109090 )

• granular keratinocytes in mutants contain vesicles devoid of lamellae or with disorganized lamellae

• disorganized lamellae form aggregates at the apical pole of granular keratinocytes