Phenotypes associated with this allele

• Allele Symbol: Tg(Defcr2-TAg)#Jig
• Allele Name: transgene insertion #, Jeffrey I Gordon
• Allele ID: MGI:2387572
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Egr1^tm1Jmi/Egr1^tm1Jmi Tg(Defcr2-TAg)#Jig/?	involves: 129 * C57BL/6 * FVB/N	MGI:4821396
tg2	Tg(Defcr2-TAg)#Jig/0	FVB/N-Tg(Defcr2-TAg)#Jig	MGI:3697307

Genotype
MGI:4821396

cx1

• Allelic Composition: Egr1^tm1Jmi/Egr1^tm1Jmi; Tg(Defcr2-TAg)#Jig/?
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased prostate gland tumor incidence ( J:67125 )

• rate of prostatic intra-epithelial neoplasia formation is similar to controls

• significantly fewer foci of invasive carcinomas at both 25 and 35 weeks

• tumors smaller than in controls

mortality/aging

premature death ( J:67125 )

• mortality due to prostate cancer

• survival time about 46.5 weeks as compared to 35-36 weeks for controls

neoplasm

decreased tumor incidence ( J:67125 )

• 70% are free of tumors at 35 weeks of age

decreased prostate gland tumor incidence ( J:67125 )

• rate of prostatic intra-epithelial neoplasia formation is similar to controls

• significantly fewer foci of invasive carcinomas at both 25 and 35 weeks

• tumors smaller than in controls

cardiovascular system

decreased angiogenesis ( J:67125 )

• less angiogenesis at 25 weeks of age

• lower microvascular density

cellular

cellular phenotype ( J:67125 )

N • cellular proliferation rate equivalent to controls

reproductive system

decreased prostate gland tumor incidence ( J:67125 )

• rate of prostatic intra-epithelial neoplasia formation is similar to controls

• significantly fewer foci of invasive carcinomas at both 25 and 35 weeks

• tumors smaller than in controls

Genotype
MGI:3697307

tg2

• Allelic Composition: Tg(Defcr2-TAg)#Jig/0
• Genetic Background: FVB/N-Tg(Defcr2-TAg)#Jig

digestive/alimentary system

abnormal small intestine crypts of Lieberkuhn morphology ( J:43025 )

• 2- to 3-fold increase in the number of goblet cells in duodenal, jejunal, and ileal sections

• in distal jejunal sections the numbers of intermediate and granule goblet cells are increased

• however, mice do not develop intestinal tumors

decreased Paneth cell number ( J:43025 )

• 90 - 95% reduction in the number of Paneth cells at P28 and the area normally occupied by mature Paneth cells is partially filled with crypt base columnar cells as well as intermediate cells

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:43025 )

• 2- to 3-fold increase in the number of goblet cells in duodenal, jejunal, and ileal sections

• in distal jejunal sections the numbers of intermediate and granule goblet cells are increased

• however, mice do not develop intestinal tumors

decreased Paneth cell number ( J:43025 )

• 90 - 95% reduction in the number of Paneth cells at P28 and the area normally occupied by mature Paneth cells is partially filled with crypt base columnar cells as well as intermediate cells