All Phenotypes Igh-7<tm1Led> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igh-7^tm1Led
targeted mutation 1, Philip Leder
MGI:2387579

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh-7^tm1Led/Igh-7^tm1Led	C.129S4-Igh-7^tm1Led	MGI:3783333
hm2	Igh-7^tm1Led/Igh-7^tm1Led	involves: 129S4/SvJae * Black Swiss	MGI:3603569
cx3	Igh-7^tm1Led/Igh-7^tm1Led Lyn^tm1Ard/Lyn^tm1Ard	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:4462262

Allelic Composition	Igh-7^tm1Led/Igh-7^tm1Led
Genetic Background	C.129S4-Igh-7^tm1Led

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-7^tm1Led mutation (1 available); any Igh-7 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired eosinophil recruitment ( J:133373 )

• there is almost a two-fold reduction in the number of eosinophils recruited to sites of T. spiralis infection in tongue skeletal muscle

hematopoietic system

impaired eosinophil recruitment ( J:133373 )

• there is almost a two-fold reduction in the number of eosinophils recruited to sites of T. spiralis infection in tongue skeletal muscle

Allelic Composition	Igh-7^tm1Led/Igh-7^tm1Led
Genetic Background	involves: 129S4/SvJae * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-7^tm1Led mutation (1 available); any Igh-7 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:19552 )

N	• in spite of the absence of IgE, mice display typical systemic anaphylactic responses

Allelic Composition	Igh-7^tm1Led/Igh-7^tm1Led Lyn^tm1Ard/Lyn^tm1Ard
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-7^tm1Led mutation (1 available); any Igh-7 mutation (1 available)
Lyn^tm1Ard mutation (6 available); any Lyn mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased basophil cell number ( J:161523 )

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

increased IgM level ( J:161523 )

immune system

increased basophil cell number ( J:161523 )

decreased B cell number ( J:161523 )

• in the bone marrow, blood and spleen

increased IgA level ( J:161523 )

increased IgM level ( J:161523 )

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

increased anti-nuclear antigen antibody level ( J:161523 )

• yet decreased compared to Lyn single mutant

increased anti-double stranded DNA antibody level ( J:161523 )

• yet decreased compared to Lyn single mutant

homeostasis/metabolism

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

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