All Phenotypes Adra1a<tm1Pcs> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adra1a^tm1Pcs/Adra1a^tm1Pcs	involves: 129X1/SvJ * FVB/N	MGI:2653821
ht2	Adra1a^tm1Pcs/Adra1a⁺	involves: 129X1/SvJ * FVB/N	MGI:3625478
cx3	Adra1a^tm1Pcs/Adra1a^tm1Pcs Adra1b^tm1Cta/Adra1b^tm1Cta	B6.129-Adra1b^tm1Cta Adra1a^tm1Pcs	MGI:3689510
cx4	Adra1a^tm1Pcs/Adra1a^tm1Pcs Adra1b^tm1Cta/Adra1b^tm1Cta	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3689509

Allelic Composition	Adra1a^tm1Pcs/Adra1a^tm1Pcs
Genetic Background	involves: 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adra1a^tm1Pcs mutation (1 available); any Adra1a mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased heart rate variability ( J:77732 )

• by ECG telemetry, conscious homozygotes show a 14% reduction in basal heart rate variability, suggesting increased sympathetic balance

hypotension ( J:77732 )

• by tail cuff manometer and arterial catheter, conscious homozygotes are hypotensive at rest, with a ~10-15 mm Hg reduction in blood pressure (8-12% of wild-type mice)

• tail cuff pressure is also reduced in a smaller cohort of homozygotes in the C57BL/6 background whereas heart rate is slightly but not significantly higher relative to wild-type mice

• no differences in body weight, heart weight, heart histology, blood chemistry, blood cell counts, cardiac output or renal function are observed

decreased vasoconstriction ( J:77732 )

• homozygotes are chronically hypotensive due to loss of vasoconstriction and consequent reduction of vasomotor tone

muscle

decreased vasoconstriction ( J:77732 )

• homozygotes are chronically hypotensive due to loss of vasoconstriction and consequent reduction of vasomotor tone

Allelic Composition	Adra1a^tm1Pcs/Adra1a⁺
Genetic Background	involves: 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adra1a^tm1Pcs mutation (1 available); any Adra1a mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

hypotension ( J:77732 )

• heterozygotes are intermediately hypotensive relative to wild-type and homozygous mutant mice

Allelic Composition	Adra1a^tm1Pcs/Adra1a^tm1Pcs Adra1b^tm1Cta/Adra1b^tm1Cta
Genetic Background	B6.129-Adra1b^tm1Cta Adra1a^tm1Pcs

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adra1a^tm1Pcs mutation (1 available); any Adra1a mutation (32 available)
Adra1b^tm1Cta mutation (1 available); any Adra1b mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased myocardial fiber size ( J:83876 )

• myocyte cross-sectional area and surface area are 25% smaller in males than in wild-type

small heart ( J:83876 )

• hearts are smaller in males, but not females, due to smaller myocytes

muscle

decreased myocardial fiber size ( J:83876 )

• myocyte cross-sectional area and surface area are 25% smaller in males than in wild-type

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:83876 )

• males show increased mortality after pressure overload (transverse aortic constriction), with only 56% surviving 14 days post TAC

cardiovascular system

decreased myocardial fiber size ( J:83876 )

• myocyte cross-sectional area is reduced by 33% in male hearts

abnormal heart size ( J:83876 )

small heart ( J:83876 )

• hearts are smaller in males, but not females, due to smaller myocytes

decreased heart weight ( J:83876 )

• male atrial, ventricular, and total heart wet weights are reduced by 18%, 16%, and 16%, respectively, however females have normal sized hearts

• male heart growth after weaning is 40% less than in wild-type

abnormal cardiovascular system physiology ( J:83876 )

decreased cardiac output ( J:83876 )

• cardiac output is reduced by 27% in conscious males

decreased cardiac stroke volume ( J:83876 )

• conscious males show a 20% reduction in end-diastolic volume which causes a smaller stroke volume

abnormal cardiac muscle contractility ( J:102648 )

• ventricular trabeculae have higher submaximal force at 2 mM extracellular calcium concentration than wild-type, however peaks of fura-2 calcium transients are not different, suggesting the myocardium has increased myofilament calcium sensitivity

• ventricular trabeculae have lower maximal force than wild-type at high extracellular calcium concentrations (6 mM), however peak cystolic calcium concentration is not different

• maximum tetanic force of trabeculae is lower than in wild-type

• trabeculae develop higher forces at all pacing rates tested than wild-type

increased heart left ventricle muscle contractility ( J:83876 )

• in anesthetized males, but not conscious males, indices of contractility (fractional shortening and ejection fraction) are increased slightly and left ventricular wall thickness and mass and end-systolic chamber size are reduced and the left ventricle end-diastolic chamber size tends to be smaller

increased left ventricle developed pressure ( J:102648 )

• 2.5 mM calcium Langendorff-perfused hearts have higher developed pressure than wild-type

decreased heart rate ( J:83876 )

• conscious young males and females show reduced heart rate, although blood pressure is normal and anesthetized mice show no difference in heart rate

abnormal myocardial fiber physiology ( J:102648 )

• myocardium shows increased myofilament calcium-sensitivity and decreased responsiveness to beta-adrenergic stimulation

increased response of heart to induced stress ( J:83876 )

• males show increased mortality and heart failure after pressure overload

congestive heart failure ( J:83876 )

• heart failure is seen in males exposed to pressure overload

homeostasis/metabolism

impaired exercise endurance ( J:83876 )

• males run significantly less in both a voluntary and forced exercise test, indicating reduced exercise capacity

increased response of heart to induced stress ( J:83876 )

• males show increased mortality and heart failure after pressure overload

muscle

decreased myocardial fiber size ( J:83876 )

• myocyte cross-sectional area is reduced by 33% in male hearts

abnormal cardiac muscle contractility ( J:102648 )

• ventricular trabeculae have lower maximal force than wild-type at high extracellular calcium concentrations (6 mM), however peak cystolic calcium concentration is not different

• maximum tetanic force of trabeculae is lower than in wild-type

• trabeculae develop higher forces at all pacing rates tested than wild-type

increased heart left ventricle muscle contractility ( J:83876 )

renal/urinary system

enlarged kidney ( J:83876 )

• females exhibit larger kidneys than wild-type

behavior/neurological

impaired exercise endurance ( J:83876 )

• males run significantly less in both a voluntary and forced exercise test, indicating reduced exercise capacity

growth/size/body

enlarged kidney ( J:83876 )

• females exhibit larger kidneys than wild-type

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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