All Phenotypes Pou4f1<tm1Nat> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pou4f1^tm1Nat
targeted mutation 1, Jeremy Nathans
MGI:2387665

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pou4f1^tm1Nat/Pou4f1^tm1Nat	involves: 129S7/SvEvBrd	MGI:3697698
hm2	Pou4f1^tm1Nat/Pou4f1^tm1Nat	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3040967
ht3	Pou4f1^tm1Et/Pou4f1^tm1Nat	involves: 129/Sv * 129S4/SvJae * 129S7/SvEvBrd	MGI:3718048
cn4	Pou4f1^tm1Nat/Pou4f1^tm2.1Nat Tg(Pax6-cre,GFP)2Pgr/0	involves: 129 * 129S7/SvEvBrd	MGI:3842429

Allelic Composition	Pou4f1^tm1Nat/Pou4f1^tm1Nat
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f1^tm1Nat mutation (0 available); any Pou4f1 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal trigeminal nerve morphology ( J:67059 )

• by E11.5 abnormal axon bundles emerge from trigeminal ganglia

• premature branching of nerves, particularly the ophthalmic and maxillary branches

• sensory neurons from the maxillary division fail to encircle whisker follicles in a normal fashion

Allelic Composition	Pou4f1^tm1Nat/Pou4f1^tm1Nat
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f1^tm1Nat mutation (0 available); any Pou4f1 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Behavioral differences between +/+ wild-type and Pou4f1^tm1Nat/Pou4f1^tm1Nat mice at birth

mortality/aging

neonatal lethality, complete penetrance ( J:35877 )

• homozygotes die within the first 24 hours after birth

behavior/neurological

absent gastric milk in neonates ( J:35877 )

absent suckling reflex ( J:35877 )

impaired righting response ( J:35877 )

• as a result of a lack of coordinated limb and trunck movements

nervous system

abnormal medulla oblongata morphology ( J:35877 )

• reduced cell number in the caudal region of the olivary nucleus

abnormal red nucleus morphology ( J:35877 )

• large neurons of the red nucleus are missing

abnormal epithalamus morphology ( J:35877 )

• 2 fold reduction in cell numbers in the medial habenula

abnormal cranial ganglia morphology ( J:35877 )

cochlear ganglion hypoplasia ( J:70744 )

• 30% reduction of neurons in the spiral ganglion

• neurons are scattered and some are not well separated from the vestibular ganglion

• losses of sensory neurons in the cochlea as well as of afferent innervation

• misdirected fibers throughout the cochlea

small geniculate ganglion ( J:70744 )

• 30-50% reduction of neurons at E18.5

small trigeminal ganglion ( J:35877 , J:54859 )

• volume of trigeminal ganglion about 1/2 normal just before birth (J:35877)

• increased density of smaller cells (J:35877)

• increased incidence of apoptotic cell death at E15.5 (J:54859)

• neuronal number begins to drop between E11.5 and E15.5 (J:54859)

• at birth neuron number about 30% normal (J:54859)

abnormal vestibular ganglion morphology ( J:70744 )

• volume is decreased and the size of neurons is decreased

Allelic Composition	Pou4f1^tm1Et/Pou4f1^tm1Nat
Genetic Background	involves: 129/Sv * 129S4/SvJae * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f1^tm1Et mutation (0 available); any Pou4f1 mutation (13 available)
Pou4f1^tm1Nat mutation (0 available); any Pou4f1 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:123264 )

vision/eye

vision/eye phenotype ( J:123264 )

N	• no differences are seen in the optic chiasm or tracts at E16.5 or in retinofungal projections at E18.5

Allelic Composition	Pou4f1^tm1Nat/Pou4f1^tm2.1Nat Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background	involves: 129 * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pou4f1^tm1Nat mutation (0 available); any Pou4f1 mutation (13 available)
Pou4f1^tm2.1Nat mutation (1 available); any Pou4f1 mutation (13 available)
Tg(Pax6-cre,GFP)2Pgr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal retina ganglion cell morphology ( J:147350 )

• the ratio of bistratified:monostratified retinal ganglion cells (RGC) increases from 0.22 in controls to 1.5 in these mice

• there is an absence of RGC dendrites in a narrow stripe of the inner plexiform layer (IPL) that coincides with the boundary between the ON and OFF RGC subtypes

• this gap in RGC dendrites is evident at P4 before the IPL has completely differentiated

vision/eye

abnormal retina ganglion cell morphology ( J:147350 )

• the ratio of bistratified:monostratified retinal ganglion cells (RGC) increases from 0.22 in controls to 1.5 in these mice

• there is an absence of RGC dendrites in a narrow stripe of the inner plexiform layer (IPL) that coincides with the boundary between the ON and OFF RGC subtypes

• this gap in RGC dendrites is evident at P4 before the IPL has completely differentiated

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