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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hmgb2tm1Meb
targeted mutation 1, Marco E Bianchi
MGI:2387671
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hmgb2tm1Meb/Hmgb2tm1Meb Not Specified MGI:3615575


Genotype
MGI:3615575
hm1
Allelic
Composition		 Hmgb2tm1Meb/Hmgb2tm1Meb
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgb2tm1Meb mutation (0 available); any Hmgb2 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
teratozoospermia ( J:67968 )
• structurally abnormal sperm
asthenozoospermia ( J:67968 )
• more than 95% of sperm are non motile

reproductive system
teratozoospermia ( J:67968 )
• structurally abnormal sperm
asthenozoospermia ( J:67968 )
• more than 95% of sperm are non motile
abnormal seminiferous tubule morphology ( J:67968 )
• histological abnormalities in organization after 30 days of age
• becomes more serious with advancing age
• loss of regular periphery to lumen progression of spermatogonia, spermatocytes, spermatids and spermatozoa
• gaps among cells
• increased levels of apoptosis
abnormal Sertoli cell morphology ( J:67968 )
• degenerated Sertoli cells
cryptorchism ( J:67968 )
• failure of testes to descend in about 1/3 of homozygous males although testis size normal
• testes descended in older males

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:67968 )
• histological abnormalities in organization after 30 days of age
• becomes more serious with advancing age
• loss of regular periphery to lumen progression of spermatogonia, spermatocytes, spermatids and spermatozoa
• gaps among cells
• increased levels of apoptosis
abnormal Sertoli cell morphology ( J:67968 )
• degenerated Sertoli cells
cryptorchism ( J:67968 )
• failure of testes to descend in about 1/3 of homozygous males although testis size normal
• testes descended in older males




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory