About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hmgb2tm1Meb
targeted mutation 1, Marco E Bianchi
MGI:2387671
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hmgb2tm1Meb/Hmgb2tm1Meb Not Specified MGI:3615575


Genotype
MGI:3615575
hm1
Allelic
Composition		 Hmgb2tm1Meb/Hmgb2tm1Meb
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmgb2tm1Meb mutation (0 available); any Hmgb2 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
teratozoospermia ( J:67968 )
• structurally abnormal sperm
asthenozoospermia ( J:67968 )
• more than 95% of sperm are non motile

reproductive system
teratozoospermia ( J:67968 )
• structurally abnormal sperm
asthenozoospermia ( J:67968 )
• more than 95% of sperm are non motile
abnormal seminiferous tubule morphology ( J:67968 )
• histological abnormalities in organization after 30 days of age
• becomes more serious with advancing age
• loss of regular periphery to lumen progression of spermatogonia, spermatocytes, spermatids and spermatozoa
• gaps among cells
• increased levels of apoptosis
abnormal Sertoli cell morphology ( J:67968 )
• degenerated Sertoli cells
cryptorchism ( J:67968 )
• failure of testes to descend in about 1/3 of homozygous males although testis size normal
• testes descended in older males

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:67968 )
• histological abnormalities in organization after 30 days of age
• becomes more serious with advancing age
• loss of regular periphery to lumen progression of spermatogonia, spermatocytes, spermatids and spermatozoa
• gaps among cells
• increased levels of apoptosis
abnormal Sertoli cell morphology ( J:67968 )
• degenerated Sertoli cells
cryptorchism ( J:67968 )
• failure of testes to descend in about 1/3 of homozygous males although testis size normal
• testes descended in older males




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory