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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prnptm2Edin
targeted mutation 2, Edinburgh University
MGI:2387688
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prnptm2Edin/Prnptm2Edin B6.129P2-Prnptm2Edin MGI:4821389
ht2
 		Prnptm1Tuzi/Prnptm2Edin involves: 129P2/OlaHsd MGI:3053020
ht3
 		Prnptm2Tuzi/Prnptm2Edin involves: 129P2/OlaHsd MGI:3053029
cn4
 		Prnptm2Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/? 		involves: 129P2/OlaHsd * BALB/cJ MGI:3053024
cn5
 		Prnptm1Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/? 		involves: 129P2/OlaHsd * BALB/cJ MGI:3053022
cx6
 		Prnptm2Edin/Prnptm2Edin
Tg(APPswe,PSEN1dE9)85Dbo/0 		B6.Cg-Prnptm2Edin Tg(APPswe,PSEN1dE9)85Dbo MGI:5050418
cx7
 		Prnptm2Edin/Prnptm2Edin
Tg(Prnp)a20Cwe/0 		B6.Cg-Prnptm2Edin Tg(Prnp)a20Cwe MGI:4821388


Genotype
MGI:4821389
hm1
Allelic
Composition		 Prnptm2Edin/Prnptm2Edin
Genetic
Background		 B6.129P2-Prnptm2Edin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Edin mutation (7 available); any Prnp mutation (142 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:107170 )
• in culture, neuron precursors remain undifferentiated for longer than in wild-type mice
abnormal neuronal precursor proliferation ( J:107170 )
• cultured adult neural precursors exhibit decreased proliferate compared with wild-type cells

cellular
abnormal neuron differentiation ( J:107170 )
• in culture, neuron precursors remain undifferentiated for longer than in wild-type mice
abnormal neuronal precursor proliferation ( J:107170 )
• cultured adult neural precursors exhibit decreased proliferate compared with wild-type cells




Genotype
MGI:3053020
ht2
Allelic
Composition		 Prnptm1Tuzi/Prnptm2Edin
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Tuzi mutation (0 available); any Prnp mutation (142 available)
Prnptm2Edin mutation (7 available); any Prnp mutation (142 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to prion infection ( J:92302 )
• no signs of TSE disease are seen 410 days postinfection an increased incubation time compared to wild-type mice or mutants with cre recombination




Genotype
MGI:3053029
ht3
Allelic
Composition		 Prnptm2Tuzi/Prnptm2Edin
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Edin mutation (7 available); any Prnp mutation (142 available)
Prnptm2Tuzi mutation (0 available); any Prnp mutation (142 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to prion infection ( J:92302 )
• an increased incubation time for TSE strain ME7 compared to wild-type mice
• this incubation time is similar to that for Prnptm2Edin heterozygotes




Genotype
MGI:3053024
cn4
Allelic
Composition		 Prnptm2Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/?
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Edin mutation (7 available); any Prnp mutation (142 available)
Prnptm2Tuzi mutation (0 available); any Prnp mutation (142 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to prion infection ( J:92302 )
• no signs of TSE disease are seen 520 days postinfection an increased incubation time compared to wild-type or or mutants without cre recombination




Genotype
MGI:3053022
cn5
Allelic
Composition		 Prnptm1Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/?
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Tuzi mutation (0 available); any Prnp mutation (142 available)
Prnptm2Edin mutation (7 available); any Prnp mutation (142 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to prion infection ( J:92302 )
• following cre recombination to remove the stop signal TSE strain ME7 incubation time is similar to that heterozygous Prnptm2Edin mice




Genotype
MGI:5050418
cx6
Allelic
Composition		 Prnptm2Edin/Prnptm2Edin
Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic
Background		 B6.Cg-Prnptm2Edin Tg(APPswe,PSEN1dE9)85Dbo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Edin mutation (7 available); any Prnp mutation (142 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:160557 )
N
• unlike transgenic mice wild-type for Prnp, life span is similar to wild-type in transgenic mice null for Prnp

behavior/neurological
behavior/neurological phenotype ( J:160557 )
N
• unlike transgenic mice wild-type for Prnp, spatial learning and passive avoidance behavior are similar to controls in transgenic mice null for Prnp

nervous system
nervous system phenotype ( J:160557 )
N
• unlike transgenic mice wild-type for Prnp, axon degeneration and synapse loss are not seen in transgenic mice null for Prnp
amyloid beta deposits ( J:160557 )
• plaque burdens are minimally different from transgenic mice wild-type for Prnp
astrocytosis ( J:160557 )
• astrogliosis is similar to transgenic mice wild-type for Prnp

homeostasis/metabolism
amyloid beta deposits ( J:160557 )
• plaque burdens are minimally different from transgenic mice wild-type for Prnp




Genotype
MGI:4821388
cx7
Allelic
Composition		 Prnptm2Edin/Prnptm2Edin
Tg(Prnp)a20Cwe/0
Genetic
Background		 B6.Cg-Prnptm2Edin Tg(Prnp)a20Cwe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Edin mutation (7 available); any Prnp mutation (142 available)
Tg(Prnp)a20Cwe mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal precursor proliferation ( J:107170 )
• cultured adult neural precursors exhibit increased proliferate compared with wild-type cells

cellular
abnormal neuronal precursor proliferation ( J:107170 )
• cultured adult neural precursors exhibit increased proliferate compared with wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory